Long-acting amoxicillin-colistin sulfate injection and preparation method thereof

A technology of amoxicillin sulfuric acid and colistin sulfate, which is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, antibacterial drugs, etc. , animal stress response and other issues, to achieve the effect of reducing medication costs and labor costs, increasing efficacy and effective time, and avoiding stress responses

Active Publication Date: 2017-10-20
江西益昕葆生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yet the main shortcoming of existing amoxicillin colistin sulfate injection is that it is not easy to preserve for a long time, and the action time is short, and it needs continuous injection for several days to play a continuous bactericidal effect, which not only increases the breeding cost of the farm, but also prone to stress responses in animals

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  • Long-acting amoxicillin-colistin sulfate injection and preparation method thereof

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Embodiment 1

[0031] A long-acting amoxicillin colistin sulfate injection, the injection comprising the following components and content by weight: 8 parts of amoxicillin, 0.9 parts of colistin sulfate, 1 part of suspending agent, 1.5 parts of wetting agent , 0.3 parts of antioxidant, 0.5 parts of zinc oxide, 0.8 parts of clavulanic acid, 2.5 parts of pH stabilizer and 80 parts of dispersing medium.

[0032] Wherein, the suspending agent is a mixture of aluminum monostearate and cholesterol, and in the suspending agent, the mass ratio of aluminum monostearate to cholesterol is 4.5:1; the wetting agent is hydrogenated castor oil; the antioxidant is vitamin E ; The preparation method of pH stabilizer is: after mixing potassium dihydrogen phosphate and sodium hydroxide solution, add water to dilute, the molar concentration of sodium hydroxide solution is 0.05mol / L, add 0.7g dihydrogen phosphate in every 100mL water Potassium and 12mL sodium hydroxide solution; the dispersion medium includes so...

Embodiment 2

[0038] A long-acting amoxicillin colistin sulfate injection, which comprises the following components and content by weight: 12 parts of amoxicillin, 0.2 parts of colistin sulfate, 3 parts of suspending agent, and 0.5 part of wetting agent , 0.8 parts of antioxidant, 0.2 parts of zinc oxide, 1.5 parts of clavulanic acid, 1.2 parts of pH stabilizer and 150 parts of dispersing medium.

[0039] Wherein, the suspending agent is a mixture of aluminum monostearate and cholesterol, and in the suspending agent, the mass ratio of aluminum monostearate to cholesterol is 3.5:1; the wetting agent is hydrogenated castor oil; the antioxidant is formaldehyde Sodium sulfoxylate; the preparation method of pH stabilizer is as follows: after mixing potassium dihydrogen phosphate and sodium hydroxide solution, add water to dilute, the molar concentration of sodium hydroxide solution is 0.15mol / L, and add 0.6g Potassium dihydrogen phosphate and 18 mL of sodium hydroxide solution; the dispersion me...

Embodiment 3

[0045] A long-acting amoxicillin colistin sulfate injection comprising the following components and parts by weight: 9 parts of amoxicillin, 0.7 parts of colistin sulfate, 1.5 parts of suspending agent, and 1.2 parts of wetting agent , 0.4 parts of antioxidant, 0.4 parts of zinc oxide, 1 part of clavulanic acid, 2.2 parts of pH stabilizer and 100 parts of dispersing medium.

[0046] Wherein, the suspending agent is a mixture of aluminum monostearate and cholesterol, and in the suspending agent, the mass ratio of aluminum monostearate to cholesterol is 4:1; the wetting agent is hydrogenated castor oil; the antioxidant is vitamin E ; The preparation method of pH stabilizer is: after mixing potassium dihydrogen phosphate and sodium hydroxide solution, add water to dilute, the molar concentration of sodium hydroxide solution is 0.1mol / L, add 0.65g dihydrogen phosphate in every 100mL water Potassium and 15mL sodium hydroxide solution; the dispersion medium includes soybean oil, ben...

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Abstract

The invention relates to a long-acting amoxicillin-colistin sulfate injection and a preparation method thereof. The injection comprises, by weight, 8 to 12 parts of amoxicillin, 0.2 to 0.9 parts of colistin sulfate, 1 to 3 parts of a suspending aid, 0.5 to 1.5 parts of a wetting agent, 0.3 to 0.8 parts of an antioxidant, 0.2 to 0.5 parts of zinc oxide, 0.8 to 1.5 parts of clavulanic acid, 1.2 to 2.5 parts of a pH stabilizer and 80 to 150 parts of a dispersion medium. In preparation, the suspending aid, wetting agent, antioxidant, zinc oxide, clavulanic acid and pH stabilizer are added into the dispersion medium, amoxicillin and colistin sulfate are added into the mixture and the mixture is ground. Compared with the prior art, the injection can reduce the dosage of the components, improve drug efficacy, prolong the pharmacodynamic metabolism time, realize the effects the same to those of the multiple interval injection processes of the same type of the conventional dosage form only through one injection process, reduce drug use frequency, reduce a drug use cost and a labor cost, prevent stress response and improve suspension adhesion effects of effective sterilization components and has good dispersity.

Description

technical field [0001] The invention belongs to the technical field of animal medicine, and relates to a long-acting amoxicillin colistin sulfate injection and a preparation method thereof. Background technique [0002] In the process of animal breeding, various antibiotics are often required for rapid treatment of diseased animals. Among them, amoxicillin is a semi-synthetic broad-spectrum antibiotic, which has a strong antibacterial effect on most Gram-positive and negative bacteria. The synthesis of cell wall mucopeptides prevents them from cross-linking and causes cell wall defects, resulting in bacterial cell rupture and death, thereby achieving the purpose of healing. [0003] As a β-lactam antibiotic, amoxicillin has strong antibacterial activity, broad antibacterial spectrum and low drug resistance, but its half-life is short, requiring frequent administration, and continuous intramuscular injection will cause greater irritation to the body. In addition, the chemic...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61K31/43A61K9/08A61K47/02A61K47/22A61K47/14A61K47/28A61K47/12A61P31/04
CPCA61K9/0019A61K9/08A61K31/43A61K38/12A61K47/02A61K47/12A61K47/14A61K47/22A61K47/28A61K2300/00
Inventor 胡鹏飞戴多亮黄静吴有林梁世仁周盛昌樊倩
Owner 江西益昕葆生物科技有限公司
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