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Pharmaceutical composition containing animal bone polypeptide

A composition and animal bone technology, applied in the direction of drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve the problems of low yield, cumbersome steps, and impact, and achieve improved safety, increased yield, and Avoiding the effects of blood pressure-lowering substances

Active Publication Date: 2013-11-06
罗诚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation process requires multiple operations such as centrifugation and concentration, and the steps are cumbersome, which is not conducive to industrial production and will have a certain impact on the yield.

Method used

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  • Pharmaceutical composition containing animal bone polypeptide
  • Pharmaceutical composition containing animal bone polypeptide
  • Pharmaceutical composition containing animal bone polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Weigh healthy fresh and frozen limb bones of pork bones, beef bones and deer bones in proportion, wash and crush them; the weight ratio of pig bones, beef bones and deer bones is 1:2:3;

[0038] 2. Grind the crushed limb bones into bone slag particles with a diameter of 2-10mm, put them into the extraction tank, add 1 times the amount of water, and use ultrasonic treatment with a frequency of 20kHz for 0.5 hours. After the ultrasonic treatment is completed, keep stirring at 100°C for 1 hour, take the supernatant; then add bone slag particles to 1 times the amount of water, and use ultrasonic treatment with a frequency of 25kHz for 0.5 hours. 600 ~ 800W, the ultrasonic emission time is 2 seconds, and the interval is 3 seconds;

[0039] 3. Combine the supernatant obtained twice in step 2, concentrate under reduced pressure to 1 / 2 of the original volume, and then freeze at -25°C to remove the upper layer of fat;

[0040] 4. Thaw the bone residue extract frozen for 3 da...

Embodiment 2

[0047] 1. Weigh healthy fresh and frozen limb bones of pork bones, beef bones and deer bones in proportion, wash and crush them; the weight ratio of pig bones, beef bones and deer bones is 2:1:2;

[0048] 2. Grind the crushed limb bones into bone slag particles with a diameter of 2-10mm, put them into the extraction tank, add 2 times the amount of water, and use ultrasonic treatment with a frequency of 25kHz for 2 hours. After the ultrasonic treatment is completed, keep stirring at 100°C for 3 hour, take the supernatant; then add bone slag particles into 2 times the amount of water, and use ultrasonic treatment with a frequency of 35kHz for 30 minutes. After the ultrasonic treatment is completed, keep stirring at 100°C for 3 hours, and take the supernatant; 800W, ultrasonic emission time is 1 second, and the interval is 3 seconds;

[0049] 3. Combine the supernatant obtained twice in step 2, concentrate under reduced pressure to 1 / 4 of the original volume, and then freeze at -...

Embodiment 3

[0057] 1. Weigh healthy fresh and frozen limb bones of pork bones, beef bones and deer bones in proportion, wash and crush them; the weight ratio of pig bones, beef bones and deer bones is 4:2:3;

[0058] 2. Grind the crushed limb bones into bone slag particles with a diameter of 2-10mm, put them into the extraction tank, add 2 times the amount of water, and use ultrasonic treatment with a frequency of 25kHz for 1 hour. After the ultrasonic treatment is completed, keep stirring at 100°C for 2 hour, take the supernatant; then add bone slag particles to 1 times the amount of water, and use ultrasonic treatment with a frequency of 30kHz for 45 minutes. After the ultrasonic treatment is completed, keep stirring at 100°C for 1 hour, and take the supernatant; 700W, the ultrasonic emission time is 1 second, and the interval is 3 seconds;

[0059] 3. Combine the supernatant obtained twice in step 2, concentrate under reduced pressure to 1 / 3 of the original volume, and then freeze at -...

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Abstract

The invention relates to a bone polypeptide product, and in particular relates to a pharmaceutical composition containing animal bone polypeptide. The pharmaceutical composition comprises the following components in parts by weight: 100 parts of polypeptide injection stock solution extracted from pig bones, cow bones and deer bones, 0.1-5 parts of chloretone and 0.5-5 parts of sodium dihydrogen phosphate. The pharmaceutical composition containing animal bone polypeptide is good in stability, extremely low in high polymer content, high in safety and extremely suitable for clinic application.

Description

technical field [0001] The invention relates to a bone polypeptide product, in particular to a pharmaceutical composition containing animal bone polypeptide. Background technique [0002] The extract extracted from animal bones, its main component is small molecule peptides, which is a mixture of small molecule peptides decomposed from collagen, which can regulate bone metabolism, stimulate osteoblast proliferation, promote new bone formation, and Regulates calcium and phosphorus metabolism, increases bone calcium deposition, and prevents osteoporosis. Clinically, it is mainly used to promote fracture healing. Among them, the polypeptide extract can directly act on osteochondrocytes and osteoclasts by supplementing and increasing various osteogenic factors, promote the synthesis of bone and cartilage matrix, and accelerate the healing and repair of injuries; at the same time, the polypeptide extract in animal bones It can also promote the secretion of growth hormone, thyroi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/02A61K35/32A61K9/08A61K9/19A61P19/08A61P19/10
Inventor 罗诚
Owner 罗诚
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