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Human insulin containing additional disulfide bonds

A technology of human insulin and disulfide bonds, which is applied in the direction of insulin, hormone peptides, animal/human proteins, etc., can solve the problems of no insulin disulfide bonds, etc., and achieve improved chemical stability, high stability, and improved physical stability. Effect

Inactive Publication Date: 2013-02-13
NOVO NORDISK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, no engineered disulfide bonds in insulin have been reported

Method used

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  • Human insulin containing additional disulfide bonds
  • Human insulin containing additional disulfide bonds
  • Human insulin containing additional disulfide bonds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0325] A10C, B1C, DESB30 -man iscardinin

[0326] Reserved time in HPLC Method 1: RT = 15.5min

[0327] Method 2: RT = 10.6min; theoretical quality = 5646.44DA; measurement quality = 5646.46DA.

[0328] Example 2, general method (a):

Embodiment 2

[0329] A10C, B2C, DESB30 people cagonin

[0330] HPLC method 1: RT = 14.3min

[0331] Method 2: RT = 10.3min; theoretical quality = 5694.44DA; measurement quality = 5694.46DA.

[0332] Example 3, common method (a):

Embodiment 3

[0333] A10C, B3C, DESB30 -man iscardinin

[0334] HPLC method 1: RT = 13.3min

[0335] Method 2: RT = 10.1min; theoretical quality = 5679.47DA; measurement quality = 5679.48DA.

[0336] Example 4, general method (a):

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PUM

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Abstract

The present invention is related to human insulin containing additional disulfide bonds and methods of making such.

Description

Area of invention [0001] The invention involves insulin and DESB30 insulin and preparation methods containing additional sulfur. Invention background [0002] Diabetes is metabolic disease. In this disease, the ability to use glucose is partially lost.In the treatment of diabetes, many kinds of insulin preparations have been proposed and used, such as conventional insulin, low -sized protein zinc insulin (called NPH), insulin zinc suspension (such as Semilente?, LENTE? And Ultralente?)Subsidine zinc insulin. [0003] Human insulin consists of two polypeptide chains, namely A and B chains, which contain 21 and 30 amino acid residues, respectively.A and B chains are connected to each other through two sulfur bonds.Insulin from most other species is similar, but may contain amino acid replacement in some positions.In the past ten years, many insulin analogs have been developed.They are designed for specific mode, that is, fast or extended.Commercial products including insulin analog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/62
CPCC07K14/62A61P3/08A61P3/10
Inventor F.胡巴莱克T.N.文瑟T.B.克杰尔德森S.卢德维格森
Owner NOVO NORDISK AS
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