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Extractive capable of reducing insulin resistance as well as preparation method and application thereof

A technology of insulin resistance and extract, which is applied in the fields of biopharmaceuticals and molecular biology, can solve problems such as multiple side effects, and achieve the effect of improving the effect and improving insulin resistance

Inactive Publication Date: 2013-02-20
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem of multiple side effects of existing drugs for improving insulin resistance, and to provide a herbal mixture extract of Ashitaba and Ginkgo biloba and its application and pharmaceutical preparations in improving insulin resistance, specifically for the application of the extract to affect incretin Histological distribution and functional level of hormone-secreting cells, and its application in the preparation of drugs for improving insulin resistance

Method used

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  • Extractive capable of reducing insulin resistance as well as preparation method and application thereof
  • Extractive capable of reducing insulin resistance as well as preparation method and application thereof
  • Extractive capable of reducing insulin resistance as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of an extract capable of improving insulin resistance

[0024] Weigh 100 g of Ashitaba and 10 g of Ginkgo leaves according to the mass ratio, mix Ashitaba and Ginkgo leaves, add 60% ethanol (the ratio of solid to liquid is 1:15), soak at room temperature for 24 hours; reflux extraction (temperature 65°C, extract twice, each time for 4 hours); filter under reduced pressure; combine the filtrates, evaporate the water with a rotary evaporator, and concentrate to make an extract.

Embodiment 2

[0025] Example 2 Preparation of an extract that can improve insulin resistance

[0026] Weigh 50 g of Ashitaba and 50 g of Ginkgo leaves according to the mass ratio, mix Ashitaba and Ginkgo leaves, add 60% ethanol (the ratio of solid to liquid is 1:15), soak at room temperature for 24 hours; reflux extraction (temperature 65°C, extract twice, each time for 4 hours); filter under reduced pressure; combine the filtrates, evaporate the water with a rotary evaporator, and concentrate to make an extract.

Embodiment 3

[0027] Example 3 Preparation of an extract that can improve insulin resistance

[0028] Weigh Ashitaba 10g and Ginkgo 100g according to the mass ratio, mix Ashitaba and Ginkgo leaves, add 60% ethanol (the ratio of solid to liquid is 1:15), soak at room temperature for 24 hours; reflux extraction (temperature 65°C , extracted twice, each time for 4 hours); vacuum filtration; combined filtrate, rotary evaporator to evaporate water, concentrated to make extract.

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Abstract

The invention provides a herbal mixture extractive of angelica keiskei and folium ginkgo capable of reducing insulin resistance. The extractive is prepared by extracting raw angelica keiskei and raw folium ginkgo based on weight ratio of 1:(0.1-10); and the extractive mainly comprises total flavone from angelica keiskei and total flavone from folium ginkgo. The invention also provides a preparation method of the extractive. The extractive shows remarkable hypoglycemic effect while being applied to a diabetic mice model and an insulin resistance rat model, and also can influence the tissue distribution and the function level of in-situ intestinal incretin secretory cells, and therefore, the insulin resistance can be treated; and the extractive can be developed and prepared into a medicine for reducing and treating insulin resistance, and thus the application of the extractive in preparation of a medicine for reducing the insulin resistance is provided.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals and molecular biology, and specifically relates to an extract of ashitaba and ginkgo biloba herbal mixture and its application and pharmaceutical preparation in improving insulin resistance. Background technique [0002] Diabetes, as a common endocrine and metabolic disease, is the third major disease that endangers human health after cardiovascular disease and cancer. Insulin resistance (Insulin Resistance, IR) refers to the decreased sensitivity of the target organ of insulin action to insulin action, that is, a state in which the normal dose of insulin produces a lower than normal biological effect. It is currently believed that IR is not only a symptom of type 2 diabetes The basis of pathogenesis is the main thread running through a variety of metabolic-related diseases, the link connecting them, and the common pathophysiological basis of these diseases. Although the research on IR...

Claims

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Application Information

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IPC IPC(8): A61K36/232A61P3/10A61P35/00A61P39/06A61P9/12A61P9/10A61P11/06A61K36/16
Inventor 戴丽季晖谭佳妮唐建兴李文雯陈同
Owner CHINA PHARM UNIV
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