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Method for regulating stimulus parameter of vagus nerve

A vagus nerve stimulation and vagus nerve technology, which is applied in the field of medical experiments, can solve the problems of long time adjustment of stimulation parameters, complicated operation, and influence on experimental results.

Inactive Publication Date: 2013-02-20
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to its complicated operation, it is often difficult to obtain ideal experimental results. Too small stimulation intensity and frequency will not cause blood pressure to drop, while too high stimulation intensity and frequency will cause blood pressure to drop, but it will cause nerve damage.
At present, there are no reports on the appropriate stimulation parameters for stimulating the vagus nerve at home and abroad.
In addition, in actual operation, because the appropriate range of stimulation parameters is not known, it often takes a long time to adjust the stimulation parameters, which affects the experimental results

Method used

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  • Method for regulating stimulus parameter of vagus nerve

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Experimental program
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Effect test

Embodiment Construction

[0015] 1. Grasping, weighing, anesthesia, immobilization

[0016] The rabbits were grabbed, weighed, and slowly injected with 20% urethane at a dose of 1 gram per kilogram of body weight from the ear vein. After anesthesia, the animal was fixed on the operating table with a rope in the dorsal position to prepare for surgery.

[0017] 2. Neck Surgery

[0018] Use coarse scissors to cut the rabbit hair in the surgical field, cut the skin 6-7 cm along the midline of the neck, separate the subcutaneous tissue and muscle along the midline with hemostatic forceps, expose the trachea and free the trachea for 2-3 cm, and thread it under the trachea for later use. . Use two hemostatic forceps to clamp the edges of the skin and muscle on both sides of the trachea, and pull them to both sides, you can see the left and right common carotid arteries that are parallel to the trachea and a bundle that goes with them on both sides of the trachea. Nerves, including the vagus nerve (the thic...

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Abstract

The invention discloses a method for regulating stimulus parameter of vagus nerve in leporidae animal arterial blood pressure regulation test, which is characterized in that after the vagus nerve is subjected to double ligation and cut off from the middle, and the peripheral end of the vagus nerve is stimulated with the stimulation intensity of 0.79+ / -0.68V and the stimulation frequency of 16.24+ / -4.49Hz.

Description

technical field [0001] The invention relates to the field of medical experimental methods, in particular to a method for adjusting vagus nerve stimulation parameters. Background technique [0002] Arterial blood pressure is an important indicator of the circulatory system, which is mainly affected by factors such as stroke volume, heart rate, peripheral resistance, the ratio of circulating blood volume to vascular volume, and the elasticity of the aortic wall. In medical teaching, the arterial blood pressure regulation experiment can be used for the screening of drugs, compounds and monomers with blood pressure regulation effect. Through the arterial blood pressure regulation experiment, you can learn the direct measurement method of arterial blood pressure, and observe the regulation of arterial blood pressure and its influencing factors by nerve and humoral factors. The vagus nerve is the tenth pair of cranial nerves. It is the longest and most widely distributed pair of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36
Inventor 杜爱林姜洪波张艳刘淑媛白瑞樱郭直岳赵茹楠王维峰张淑红杨琳红靳玫靖素华于小免冯素萍李天超谭静林瑞峰文君苏慧洁
Owner XINXIANG MEDICAL UNIV