Chinese herbal preparation resistant to hyperlipidemia and atherosclerosis and preparation method of Chinese herbal preparation

An atherosclerosis and anti-hyperlipidemia technology, applied in the field of medicine, can solve the problems of reduced HDL catabolism, high incidence of adverse reactions, and lower LDL, and achieve the effects of lowering LDL-C, clinical drug safety, and reducing impurities

Inactive Publication Date: 2013-03-06
苏州同立医药技术有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0017] (3) cause HDL catabolism to decrease;
[0025] (2) Non-blood lipid regulating effect
The former has a definite therapeutic effect on hypercholesterolemia, significantly lowering LDL, and at the same time has no effect on HDL or slightly increases it. While treating hyperlipidemia, it has a significant therapeutic effect on atherosclerosis; the latter is to reduce glycerol Most effective drug on triglyceride (TG) level, less effective on LDL-C
Although the efficacy of these drugs has been confirmed, the incidence of adverse reactions is relatively high, especially for the simultaneous treatment of high cholesterol and hypertriglyceridemia, the combined use of these two drugs can cause life-threatening serious adverse reactions such as rhabdomyolysis

Method used

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  • Chinese herbal preparation resistant to hyperlipidemia and atherosclerosis and preparation method of Chinese herbal preparation
  • Chinese herbal preparation resistant to hyperlipidemia and atherosclerosis and preparation method of Chinese herbal preparation
  • Chinese herbal preparation resistant to hyperlipidemia and atherosclerosis and preparation method of Chinese herbal preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1, the preparation of pharmaceutical tablet of the present invention

[0078] Step 1) Take 500g of seabuckthorn and 500g of Puhuang, immerse in ethanol with 8 times volume concentration ratio of 70% (V / V) for 2 hours, reflux extraction twice, the first time for 2 hours, and the second time for 7 times the amount of ethanol , 1.5 hours, filtered, the filtrates were combined, the ethanol was recovered until there was no alcohol smell, and the alcohol extract was obtained; the alcohol extract was loaded on the AB-8 macroporous resin, eluted with 1.5 times the column volume of water, and the eluent was discarded Continue to elute with 3 times of column volume and concentration of 20% (V / V) ethanol, discard the eluent after reclaiming ethanol; continue to wash with 4 times of column volume and concentration of 70% (V / V) ethanol Ethanol was recovered from the eluate, and when concentrated to 50°C, the relative density was 1.25 to obtain the seabuckthorn and Puhuang...

Embodiment 2

[0082] Embodiment 2, the preparation of pharmaceutical capsule of the present invention

[0083] Step 1) Take 800 g of seabuckthorn, soak it with 9 times the amount of 80% (V / V) ethanol for 1.5 hours, reflux extraction twice, the first time for 2 hours, the second time for 8 times the amount of ethanol for 1 hour, filter, and combine the filtrates , recover ethanol until there is no alcohol smell, and obtain the alcohol extract; load the alcohol extract on YWD12G macroporous resin, elute with 1 times column volume of water, and discard the eluate; continue to use 2 times column volume at a concentration of 30 % (V / V) ethanol was eluted, and the eluent was discarded after reclaiming ethanol; continue to elute with 4 times the column volume and a concentration of 80% (V / V) ethanol, and the eluate was reclaimed ethanol, concentrated to 40 The relative density at ℃ is 1.20, and seabuckthorn extract is obtained;

[0084] Step 2) Take 900g of Puhuang, soak it with 8 times the amoun...

Embodiment 3

[0088] Embodiment 3, the active ingredient determination of medicine of the present invention

[0089] 1. Determination of isorhamnetin, kaempferol and quercetin content

[0090] Get respectively step 3) in the embodiment 2 and dry and pass the powder (seabuckthorn and Puhuang intermediate) 0.5g of the No. Intermediate) 0.5g,

[0091] Accurately weigh, put in a stoppered Erlenmeyer flask, accurately add 50ml of ethanol, weigh, heat and reflux for 1 hour, let cool, weigh again, make up the lost weight with ethanol, shake well, filter, and accurately measure Take 25ml of the filtrate, put it in a stoppered Erlenmeyer flask, add 3.5ml of hydrochloric acid, heat and hydrolyze in a 75°C water bath for 1 hour, cool, transfer to a 50ml volumetric flask, and add ethanol to the mark.

[0092] Determination by HPLC (Appendix IVD of Chinese Pharmacopoeia 2010 Edition). Condition: octadecylsilane bonded silica gel column; mobile phase: methanol-0.4% phosphoric acid (58:42); UV detector...

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Abstract

The invention discloses a Chinese herbal preparation resistant to hyperlipidemia and atherosclerosis and a preparation process of the Chinese herbal preparation. The Chinese herbal preparation is prepared from, by weight, 0.5-3 parts of seabuckthorn fruit, 0.5-3 parts of cattail pollen and 0.3-3 parts of kelp. The Chinese herbal preparation is scientific and reasonable, conforms to the traditional Chinese medicine theory and is exact in hyperlipidemia and atherosclerosis treating efficacy as proved by modern pharmacology and toxicology test, is free of obvious toxic and side effects and safe in clinical treatment. Alcohol extraction and water extraction processes are adopted respectively in the preparation process according to physicochemical properties of active ingredients of each medical material, and accordingly the content of the active ingredients is guaranteed, impurities are reduced, taking dosage is decreased, and the preparation process is low in production cost and easy for batch production.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a traditional Chinese medicine preparation for resisting hyperlipidemia and atherosclerosis and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the most common and serious diseases that endanger human health (especially middle-aged and elderly people), and hyperlipidemia (commonly known as hyperlipidemia) caused by lipid metabolism disorders Important risk factors for other cardiovascular and cerebrovascular diseases. Lowering blood lipids can reduce the incidence and mortality of these diseases, and has a positive effect on the prevention and treatment of cardiovascular and cerebrovascular diseases. Therefore, the prevention and treatment of hyperlipidemia has attracted more and more attention. [0003] Hyperlipidemia is characterized by changes in various lipoprotein profiles in plasma, including elevated blood total cholesterol (TC), elevat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P3/06A61P9/10
Inventor 夏玉叶袁宁生闵旸
Owner 苏州同立医药技术有限公司
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