Uterine cavity hemostasis anti-adhersion temperature-sensitive gel and preparation method thereof

Abstract

The invention provides a uterine cavity hemostasis anti-adhersion temperature-sensitive gel and a preparation method thereof, and relates to a postoperative anti-adhesion gel and a preparation method thereof. The uterine cavity hemostasis anti-adhersion temperature-sensitive gel comprises the following materials in percentage by weight: 1-4% of carboxymenthyl chitosan, 17-45% of poloxamer F127, 5-20% of glycerol and the balance of purified water. The preparation method comprises the following steps: dissolving the carboxymenthyl chitosan and poloxamer F127 into warm water and cold water respectively, mixing the two solutions into glycerol, complementing water to sufficient quantity, stirring evenly, standing and defoaming in a refrigerator to obtain a colorless and transparent solution, filtering the solution with a 300-mesh sieve, sub-packaging the filtrate into a uterine perfusion device, sterilizing through cobalt-60, and storing in a refrigerating chamber for later use. The uterine cavity hemostasis anti-adhersion temperature-sensitive gel is of a medical material which is good in biocompatibility, safe, non-toxic and non-irritant, has the effects of stopping bleeding and prompting cure of wound surfaces while being anti-adhesion, thereby being more suitable for the demand of cure of clinical wound surfaces.

Description

technical field [0001] The invention relates to a postoperative anti-adhesion gel, in particular to a uterine cavity hemostasis anti-adhesion thermosensitive gel and a preparation method thereof. Background technique [0002] Intrauterine adhesions are a common gynecological disease, often caused by miscarriage or rough curettage. Intrauterine adhesions can cause amenorrhea, endometriosis, secondary infertility and habitual abortion. At present, most of the treatment methods for intrauterine adhesions use expansion rods to expand and place contraceptive rings. This method is blind, cannot restore the original shape of the uterine cavity, and has a high incidence of re-adhesions. In recent years, with the advancement of medical technology, there have been hysteroscopy or B-ultrasound monitoring for separation, but the operation is more complicated, and IUDs still need to be placed to prevent re-adhesion. Some people advocate placing a pear-shaped stent in the uterine cavity ...

AI Technical Summary

Problems solved by technology

At present, the treatment of intrauterine adhesions mostly uses expansion rods to expand and place contraceptive rings. This method is blind and cannot restore the original shape of the uterine cavity, and the incidence of re-adhesion is high.

In recent years, with the advancement of medical technology, there has been hysteroscopy or B-ultrasound monitoring for separation, but the operation is more complicated, and IUDs still need to be placed to prevent re-adhesion

Some people advocate placing a pear-shaped stent in the uterine cavity to prevent re-adhesion, but the stent is expensive and needs to be removed after one month, which increases the pain and financial burden of the patient

[0003] The Chinese patent of authorized notification number CN101318036B discloses a medical anti-adhesion intelligent gel material and its preparation method. After the glue degrades or dissolves out of the body due to use time, if the wound is not healed, it will adhere again, and the success rate of anti-adhesion is not high