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Alcohol-resistant oral pharmaceutical form

A pharmaceutical and polymer technology, applied in the field of new oral pharmaceutical preparations, which can solve the problems of unavailability, inability to resist spirits, limited alcohol tolerance, etc.

Active Publication Date: 2013-03-13
ETHYPHARM SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the maximum percentage of ethanol in the dissolution medium is 30%, the carrier is limited by its tolerance to alcohol, so the carrier is not resistant to large volumes of spirits such as whiskey or vodka
Furthermore, this patent application fails to achieve dissolution kinetics comparable to once-daily administration

Method used

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  • Alcohol-resistant oral pharmaceutical form
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Experimental program
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Embodiment Construction

[0024] The microparticles of the present invention include from the center to the periphery:

[0025] - neutral carrier,

[0026] - at least one couchede montage comprising at least one active ingredient and a pharmaceutically acceptable binder,

[0027] - at least one coating layer comprising:

[0028] - a hydrophobic coating polymer selected from water-insoluble cellulose derivatives, and

[0029] - at least 20% of an inert charge relative to the dry weight of the hydrophobic coating polymer.

[0030] The hydrophobic polymer prevents rapid release of the active ingredient.

[0031] The coating ensures a slow release of the active ingredient, according to a release kinetics particularly suited to a single dose per day or to two doses per day.

[0032] Accordingly, the present invention relates to sustained-release microparticles comprising, from the center to the periphery:

[0033] - neutral carrier,

[0034] - at least one assembly layer comprising at least one active...

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Abstract

The invention relates to a novel oral pharmaceutical composition which is resistant to immediate discharge of the dose of active ingredient due to alcohol and which enables a single daily intake.

Description

technical field [0001] The present invention relates to a novel oral pharmaceutical formulation containing microparticles with a slow release of at least one active ingredient and a release kinetics which in particular allow the patient to take a single dose per day while preventing this release from being accelerated by the simultaneous consumption of alcohol . Background technique [0002] There are many sustained release oral pharmaceutical formulations on the market. Depending on the therapeutic purpose and the pharmacological properties of the active ingredient, the release of the active ingredient must be controlled. Certain active ingredients have been shown to be highly toxic, even lethal, if ingested above certain thresholds. [0003] It is therefore imperative to strictly control their "delay" properties to ensure that no rapid-release "dose burst" of the active ingredient occurs, especially when alcohol is consumed at the same time. Alcohol consumption while ta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/485
CPCA61K31/485A61K9/5047A61K9/5078A61P25/00A61P25/04A61P25/08A61P29/00A61P31/04A61P31/12A61P5/00A61P9/00A61K9/48A61K9/50
Inventor C·埃里L·特里沙尔
Owner ETHYPHARM SA