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Preparation method of high-viscoelasticity sodium hyaluronate gel

A technology of sodium hyaluronate and elasticity, applied in skin diseases, bone diseases, aerosol delivery, etc., can solve the problems of increased production cost, reduced income, high price, etc., to improve production efficiency, improve viscoelasticity, high viscosity The effect of the bullet

Active Publication Date: 2014-07-09
SHANGHAI JINGFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1. Improving the viscoelasticity of the injection by increasing the concentration of the dosing solution will increase the production cost and reduce the profit
[0009] 2. The commonly used HA crosslinking agent is expensive, difficult to prepare, and most of them have strong toxicity
[0010] 3. After cross-linking HA gel, the cross-linking agent is difficult to remove. If the cross-linking agent residue exceeds the standard, it will bring greater risks to patients who use injections

Method used

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  • Preparation method of high-viscoelasticity sodium hyaluronate gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take the sodium hyaluronate raw material (molecular weight: 920,000), accurately weigh three parts of 2.5g, 5.0g and 7.5g, dissolve it in the PBS buffer solution prepared by the small-volume injection workshop, and prepare 0.5%, 1.0% and 1.5% % concentration of sodium hyaluronate solution, respectively numbered A-1, B-1, C-1, test and record the pH value, after the preparation is completed, take half (250ml) of the volume of the above numbered sodium hyaluronate solution, start stirring, speed 200 revolutions / min, slowly add dilute hydrochloric acid with a concentration of 1+6 into the liquid medicine at a rate of 5-20ml / min, and adjust the pH value. When the pH value drops below 3.2, observe the phenomenon at the same time, and the apparent viscosity is sharp Stop adding dilute hydrochloric acid immediately after the increase, record the final pH value, and the reaction is terminated to obtain highly viscoelastic sodium hyaluronate gels, numbered A-2B-2 and C-2 respecti...

Embodiment 2

[0029] Take the sodium hyaluronate raw material (molecular weight: 820,000), accurately weigh three parts of 2.5g, 5.0g and 7.5g, dissolve it in the PBS buffer solution prepared by the small-volume injection workshop, and prepare 0.5%, 1.0% and 1.5% % concentration of sodium hyaluronate solution, respectively numbered D-1, E-1, F-1, test and record the pH value, after the preparation is completed, take half (250ml) of the volume of the above numbered sodium hyaluronate solution, start stirring, and the speed 300 revolutions / min, slowly add dilute hydrochloric acid with a concentration of 1+4 to the liquid medicine at a rate of 5-20ml / min to adjust the pH value, when the pH value drops below 3.0, observe the phenomenon at the same time, the apparent viscosity is sharp Immediately stop adding dilute hydrochloric acid after the increase, record the final pH value, and the reaction is terminated to obtain highly viscoelastic sodium hyaluronate gels, respectively numbered D-2E-2 and...

Embodiment 3

[0031] Take the sodium hyaluronate raw material (molecular weight: 900,000), accurately weigh three parts of 2.5g, 5.0g and 7.5g, dissolve it in the PBS buffer solution prepared by the small-volume injection workshop, and prepare 0.5%, 1.0% and 1.5% % concentration of sodium hyaluronate solution, respectively numbered G-1, H-1, I-1, test and record the pH value, after the preparation is completed, take half (250ml) of the volume of the above numbered sodium hyaluronate solution, start stirring, speed 500 revolutions / min, slowly add dilute hydrochloric acid with a concentration of 1+5 to the liquid medicine at a rate of 5-20ml / min, and adjust the pH value. When the pH value drops below 3.5, observe the phenomenon at the same time, and the apparent viscosity is sharp Immediately stop adding dilute hydrochloric acid after the increase, record the final pH value, and the reaction is terminated to obtain highly viscoelastic sodium hyaluronate gels, respectively numbered G-2H-2 and I...

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Abstract

The invention relates to a preparation method of high-viscoelasticity sodium hyaluronate gel. The method comprises the steps of preparing sodium hyaluronate into a sodium hyaluronate solution with a PBS (phosphate buffer solution), adjusting pH of the sodium hyaluronate solution with an acid solution with a certain concentration to a certain specified range, and allowing the sodium hyaluronate solution to form the gel with very high viscoelasticity under a certain stirring force, wherein the concentration of the sodium hyaluronate solution is 0.05-2%. The viscoelasticity of the sodium hyaluronate gel prepared with the method is improved greatly compared with the prior art, and the sodium hyaluronate gel has better rheologic property and a certain application prospect.

Description

Technical field: [0001] The invention relates to a preparation method of high viscoelastic sodium hyaluronate gel Background technique: [0002] Hyaluronic acid (HA for short) is composed of (1→3)-2-acetylamino-2-deoxy-β-D-glucose-(1→4)-O-β-D-glucuronic acid bis A linear polysaccharide composed of sugar repeating units with the molecular formula (C 14 h 21 NO 11 )n, according to different tissue sources, the molecular weight range is 2×10 5 ~7×10 6 , the number of disaccharide units is 300 to 11,000 pairs. [0003] [0004] Commercial hyaluronic acid is generally in the form of sodium salt, white fibrous or powdery solid, with strong hygroscopicity, soluble in water, insoluble in organic solvents. The macromolecular network structure of sodium hyaluronate passes through the interaction with H 2 O forms hydrogen bonds and binds a large amount of water, and has the functions of forming various matrices, regulating osmotic pressure, regulating the transport of macromo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/728A61P41/00A61P19/02A61P17/02A61P35/00
Inventor 叶湘武付爱玲陈亮
Owner SHANGHAI JINGFENG PHARMA
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