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Medicine composition capable of enriching blood, promoting blood circulation, relaxing muscles and tendons, and activating collaterals, and preparation method of medicine composition

A technology for relaxing tendons and activating collaterals and composition, applied in the field of pharmaceutical composition containing the extract of Spatholobus Spatholobus Spatholobus as active substance

Inactive Publication Date: 2013-04-17
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] During our research on Spatholobus Spatholobus, we found that the extract of its single medicinal material has good therapeutic effects, and we have not seen the production of granules, tablets, capsules, oral We use modern technology to extract and concentrate Fengcheng Spatholobus medicinal materials to make extracts, and then prepare a series of pharmaceutically feasible products. It has important practical significance for the use and promotion of Jiangxi local medicinal material, Fengcheng Spatholobus Spatholobus

Method used

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  • Medicine composition capable of enriching blood, promoting blood circulation, relaxing muscles and tendons, and activating collaterals, and preparation method of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: Preparation of Fengcheng Spatholobus Spatholobus Tablets

[0056] Take 3000g of Fengcheng Spatholobus medicinal material, crush it, add 24000g of water to extract three times, decoct for 4 hours for the first time, decoct for 2 hours for the second time, and decoct for 1 hour for the third time, combine and extract the medicinal liquid, filter, and the filtrate is in Concentrate under reduced pressure to a clear paste with a relative density of 1.20, dry under reduced pressure at 60°C, and pulverize after drying to obtain an extract (extract A, with a weight ratio of 70%), add 25% microcrystalline cellulose and 4% carboxymethyl starch sodium, made into soft material with 80% ethanol in proper amount, made into granules, dried, granulated, added with 1% magnesium stearate in proper amount, pressed into tablets, packed separately, ready to be obtained. Each tablet is equivalent to 40 grams of Fengcheng Spatholobus Spatholobus.

Embodiment 2

[0057] Embodiment 2: Preparation of Fengcheng Jixueteng Granules

[0058] Take 3000g of Fengcheng Spatholobus medicinal material, crush it, add 18000g of water to extract three times, decoct for 4 hours for the first time, decoct for 2 hours for the second time, and decoct for 1 hour for the third time, combine and extract the medicinal liquid, filter, and the filtrate is in Concentrate under normal pressure to a clear paste with a relative density of 1.05~1.15, place it for 24 hours, take the supernatant to concentrate, dry under reduced pressure, grind into a dry powder, and obtain the extract (that is, extract B, the weight ratio is 80%), Add 20% soluble starch, use 80% ethanol to make a soft material, make granules, dry under normal pressure at 60°C, granulate, and pack into bags. Each 1 gram of granule is equivalent to 20 grams of Fengcheng Spatholobus Spatholobus.

Embodiment 3

[0059] Embodiment 3: Preparation of Fengcheng Spatholobus Capsules

[0060] Take 3000g Fengcheng Spatholobus Spatholobus medicinal material, crush it, add 8 times 50% ethanol to reflux and extract three times, the first time is 4 hours, the second time is 2 hours, the third time is 1 hour, filter, combine the filtrate, recover the ethanol from the filtrate, concentrate , dried under reduced pressure, ground into a dry powder to obtain the extract (the weight ratio of extract C is 90%), added 10% starch, made granules with 50% ethanol, dried, granulated, poured into empty capsules, and obtained. Each capsule is equivalent to 80 grams of Fengcheng Spatholobus Spatholobus.

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Abstract

The invention relates to a medicine composition capable of enriching blood, promoting blood circulation, relaxing muscles and tendons and activating collaterals, in particular to a medicine composition containing an active extractive of millettla nitida benth.var.hirsutissima Z.Wei, and a preparation method of the medicine composition. The method comprises the steps that a millettla nitida benth.var.hirsutissima Z.Wei medicinal material is adopted, extracted with a water extraction method or an alcohol extraction method, concentrated or dried and crushed, and then appropriate auxiliary materials are added to form different medicinal preparations. Contents of active components such as formononetin and general flavone are high; the mass is stable and controllable; and a prepared product per unit dosage is equivalent to 20-150g millettla nitida benth.var.hirsutissima Z.Wei medicinal material. A requirement of treatment based on syndrome differentiation can be met clinically, and a doctor can give a prescription or use flexibly. According to the medicine composition and the method, the product is good in stability, easy to store and carry; a formula is flexible; a dose is small; the medicine composition is convenient to use; and the use and popularization of a local medicinal material, namely millettla nitida benth.var.hirsutissima Z.Wei in Jiangxi, are facilitated.

Description

technical field [0001] The invention relates to a pharmaceutical composition for nourishing blood, promoting blood circulation, relaxing tendons and activating collaterals, in particular to a pharmaceutical composition containing the extract of Spatholobus Spatholobus as an active substance, and a preparation method of the pharmaceutical composition. Background technique [0002] Millettia nitita Benth.var.hirsutissima Z.Wei is the dry cane of the leguminous plant Millettia nitita Benth.var.hirsutissima Z.Wei, also known as Millettia nitita Fengcheng, was recorded in Jiangxi Province Traditional Chinese Medicine standard. It has invigorating blood circulation, nourishing blood, dredging collaterals. For numbness of limbs, paralysis, soreness of waist and knees, irregular menstruation, anemia. Fengcheng Spatholobus is a traditional Chinese medicinal material with local characteristics in Jiangxi, and has a long history of being used as medicine. In the Pharmacopoeia, Spath...

Claims

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Application Information

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IPC IPC(8): A61K36/486A61P7/06A61P29/00A61P25/02A61P15/00
Inventor 钟小群朱良辉陈新菊余华李忠贵李艳
Owner 江西省药物研究所
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