Micro-fluid self-driven micro-fluidic chip with temperature response and preparation method thereof

A microfluidic chip and temperature-responsive technology, applied to chemical instruments and methods, laboratory containers, laboratory utensils, etc., to achieve good application prospects, simple operation, and cost reduction

Inactive Publication Date: 2013-04-24
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it is difficult for conventional technologies to intelligently drive and control microfluidics in microchannels. Therefore, to drive microfluidics in microfluidic chips by controlling the change of surface wettability, it is necessary to develop a convenient, fast, efficient and low-cost Cost-effective microfluidic drive technology should be one of the research directions on how to control microfluidics on microfluidic chips, and there has been no substantial breakthrough yet

Method used

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  • Micro-fluid self-driven micro-fluidic chip with temperature response and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, bonded, and pressure-sealed to make a temperature-responsive micropump based on a microfluidic chip. The sample solution is added to the sample injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump, and the temperatur...

Embodiment 2

[0025] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, bonded, and pressure-sealed to make a temperature-responsive micropump based on a microfluidic chip. The sample solution is added to the sample injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump, and the temperature is regulated by the ...

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Abstract

The invention relates to a micro-fluid self-driven micro-fluidic chip with temperature response and a preparation method thereof. A microstructure and a micro-channel are arranged on the surface of the micro-fluidic chip; the surface of the micro-channel is modified through a temperature response molecule; when the micro-channel is stimulated by an external field temperature, the variation of surface wettability is caused by reversible variations of surface topography and chemical configuration of the micro-channel; the micro-fluid is controlled to move from the bottom up on the surface of the micro-channel, so that the micro-fluid automatically flows; and the micro-fluid self-driven micro-fluidic chip is mainly applied to the related field of electrophoretic separation, chromatographic separation, immunoassay, reaction and the like. The micro-fluidic chip is simply operated, the micro-fluid is self-driven from the bottom up, the micro-fluid driving cost is greatly reduced, the micro-fluid self-driven micro-fluidic chip is portable, economic, rapid and efficient, and a brand new micro-fluid flowing control technology is provided for micro-fluid undriven flowing.

Description

technical field [0001] The invention relates to a temperature-responsive microfluidic self-driven microfluidic chip and a preparation method thereof. The surface of the microfluidic chip has microstructures and microchannels, and the surface of the microchannel is modified by temperature-responsive molecules. Under stimulation, the reversible changes in the surface morphology and chemical configuration of the microchannel lead to changes in surface wettability, controlling the movement of microfluids from bottom to top on the surface of microchannels, thereby realizing the spontaneous flow of microfluids, mainly used in electrophoresis Separation, chromatographic separation, immunoassay, reaction and other related fields. Background technique [0002] Innovative analysis and testing technology has played an extremely important role in promoting the development of science, technology and economy all over the world in the history of human development. As a new type of analysi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 沙俊
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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