Master slice for mouthwash and preparation method thereof

A mouthwash and mother tablet technology, applied in the field of daily chemicals, can solve the problems of high irritation of the mouthwash, the inability of plant essential oils to be effectively put into the mouthwash, and the like, achieving novel product form, easy portability, storage and use, selective effect

Inactive Publication Date: 2013-05-08
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that the mouthwash is very irritating and the plant essential oil cannot be effectively put into the mother tablet of the mouthwash

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Preparation of β-cyclodextrin inclusion compound containing eucalyptus oil

[0051] Weigh 8g of β-CD into the Erlenmeyer flask, add appropriate amount of distilled water, and place it in a digital display constant temperature magnetic stirring water bath, heat and stir at 40°C to dissolve, make a saturated solution, fix the speed, slowly add precision while stirring Measure 1 mL of absolute ethanol solution of eucalyptus oil (1:1 volume ratio of eucalyptus oil and absolute ethanol), continue stirring at 40°C for 5 h, cool to room temperature, and refrigerate for 24 h. Suction filter with 0.45μm organic microporous membrane, wash the precipitate with a small amount of distilled water and petroleum ether until there is no smell of eucalyptus oil, and dry it under vacuum at 40°C to constant weight to obtain eucalyptus oil-CD inclusion complex in white powder .

Embodiment 2

[0052] Example 2 Preparation of β-cyclodextrin inclusion compound containing methyl salicylate

[0053] Weigh 8g of β-CD into the Erlenmeyer flask, add appropriate amount of distilled water, and place it in a digital display constant temperature magnetic stirring water bath, heat and stir at 40°C to dissolve, make a saturated solution, fix the speed, slowly add precision while stirring Measure 1mL of anhydrous ethanol solution of methyl salicylate (prepared from methyl salicylate and absolute ethanol at a volume ratio of 1:1), continue stirring at 40°C for 5 h, cool to room temperature, and place Refrigerate for 24 hours, filter with a 0.45 μm organic microporous membrane, wash the precipitate with a small amount of distilled water and petroleum ether until there is no smell of methyl salicylate, and dry it in vacuum at 40°C to constant weight to obtain salicylic acid in the form of white powder Acid methyl ester-CD clathrate.

Embodiment 3

[0054] Example 3 Preparation of β-cyclodextrin inclusion compound containing mugwort oil

[0055] Weigh 8g of β-CD into the Erlenmeyer flask, add appropriate amount of distilled water, and place it in a digital display constant temperature magnetic stirring water bath, heat and stir at 40°C to dissolve, make a saturated solution, fix the speed, slowly add precision while stirring Measure 1mL of absolute ethanol solution of Artemisia argyi leaf oil (Argyra leaf oil and absolute ethanol are prepared at a volume ratio of 1:1), continue to stir at 40°C for 5 h, cool to room temperature, refrigerate for 24 h, and use 0.45 The μm organic microporous membrane was suction-filtered, and the precipitate was washed with a small amount of distilled water and petroleum ether until there was no smell of mugwort oil, and vacuum-dried at 40°C to constant weight to obtain the inclusion compound of mugwort oil-CD in the form of white powder.

[0056] 2. Preparation of the parent tablet of mouth...

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PUM

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Abstract

The invention provides a master slice for mouthwash. The master slice comprises functional ingredients and a forming accessory, wherein the forming accessory comprises a filling agent, an effervescing agent, an adhesive, a disintegrating agent, a flavoring agent and a lubricating agent, and when the functional raw materials are oil substances, the raw materials are coated by employing beta-cyclodextrin to form the oily functional beta-cyclodextrin inclusion compound. The master slice for mouthwash can be disintegrated in warm water below 50 DEG C within two minutes, and the disintegrated aqueous solution can be used for rinsing the teeth; and moreover, the advantages of toothpaste, chewing gum, mouthwash and other conventional mouth care products are integrated by the master slice for mouthwash, and the disadvantages are eliminated.

Description

technical field [0001] The invention relates to the field of daily chemicals, in particular to a mother tablet containing mouthwash and a preparation method thereof. Background technique [0002] The mouth is the beginning of the digestive tract and has many important functions. Oral care is an important part of basic care. First of all, healthy teeth can make people look good and feel better in daily life such as eating and speaking. Secondly, good oral care for critically ill patients can avoid some complications, and the condition can be observed according to the health of the oral cavity. Third, disease in the oral cavity is a harbinger of disease in other parts of the body. For example, dry oral mucosa is the first signal of water and salt metabolism disorders; patients with anemia may have persistent oral ulcers and pharyngitis; patients with leukemia may have bleeding gums. Fourth, the environment in the oral cavity is moist and rich in nutrients, which is conveni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/92A61K8/86A61K8/81A61K8/73A61K8/60A61K8/49A61K8/34A61Q11/00
CPCA61K36/744A61K47/48A61K8/022A61K8/738A61K9/0007A61K9/0053A61K36/00A61K2800/222A61Q11/00
Inventor 蒋庆于艳君李慧
Owner SUN YAT SEN UNIV
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