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Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition

A technology for hypertension and composition, applied in the field of traditional Chinese medicine composition and preparation thereof, can solve problems such as toxic side effects, difficulty in reducing blood pressure to an ideal level, etc., and achieve the effects of lowering blood pressure, improving blood lipid level, and correcting lipid metabolism

Inactive Publication Date: 2015-07-01
INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the resistance of hypertension to western medicine, it is often difficult to lower the blood pressure to the ideal level with only western medicine, and because hypertension advocates life-long medication to reduce the damage of the disease to terminal organs, the resulting toxic and side effects are the patient's It is a common concern with doctors, so we are looking for treatment measures that can counteract the resistance of Western medicine to treat hypertension, enhance the clinical antihypertensive effect, or reduce the dosage of Western medicine or even withdraw Western medicine, regardless of the effectiveness and rationality of the treatment of hypertension. It has clinical significance for in-depth research in highlighting the curative effect advantages of traditional Chinese medicine and reducing medical expenses

Method used

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  • Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition
  • Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition
  • Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition

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Experimental program
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Effect test

experiment example 1

[0052] 1 Materials and methods

[0053] 1.1 Case selection

[0054] 1.1.1 Western medicine diagnostic criteria

[0055] The diagnosis of hypertension refers to the 1999 World Health Organization and International Society of Hypertension (WHO / ISH) guidelines for the management of hypertension (the fourth revised edition); 3 issues.

[0056] 1.1.2 Diagnostic criteria of TCM syndromes

[0057] Syndrome of phlegm and blood stasis, toxin damage to the heart collaterals: Main symptoms: dizziness, headache, headache, chest tightness, chest pain, cough and spit, dark purple lips and nails, sublingual collateral veins. The tongue is dark, with petechiae or ecchymosis, white and greasy fur, stringy and slippery pulse or deep astringent or intermittent pulse. Secondary symptoms: palpitations, insomnia, light mouth, lack of food, body fat.

[0058] 1.1.3 Case inclusion criteria

[0059] Those who meet the above diagnostic criteria of western medicine, grade 1 and 2 hypertension and ...

Embodiment 1

[0095] Chinese medicine composition crude drug of the present invention consists of:

[0096] Chuanxiong 10g, Alisma 10g, radish seed 10g, seaweed 15g, leech 5g

[0097] Chinese medicine composition preparation method of the present invention comprises the steps:

[0098] A. Chuanxiong percolation method

[0099] Take the crude drug of Rhizoma Chuanxiong, wash it, crush it into coarse powder, use 40% ethanol as a solution, soak it for 48 hours, collect 600ml of the initial exudate, and infiltrate the rest until the exudate reaches 4 times the volume of the crude drug, distill and recover the ethanol, and use 70% ethanol as the solution. Concentrate into a thick paste at ℃, add the initial exudate, stir to dissolve, adjust the total extract, calculated based on the content of ligustrazine and ferulic acid, the content per ml is 0.28mg, let it stand for 96h, take the supernatant and filter, precipitate water Decoct with alcohol, filter, recover ethanol, add the supernatant to ...

Embodiment 2

[0104] Chinese medicine composition crude drug of the present invention consists of:

[0105] Chuanxiong 8g, Alisma 6g, radish seed 16g, seaweed 14g, leech 5g

[0106] The preparation method of Chinese medicine composition of the present invention comprises the steps:

[0107] A. Chuanxiong percolation method

[0108]Take the formula amount of Chuanxiong crude drug, wash it, crush it into coarse powder, use 35% ethanol as a solution, soak for 55 hours, collect the initial exudate 700ml, and infiltrate the rest until the exudate reaches 3 times the volume of the crude drug, distill and recover ethanol, and use 65% ethanol Concentrate into a thick paste at ℃, add the initial exudate, stir to dissolve, adjust the total extract content, calculated based on the content of ligustrazine and ferulic acid, the content per ml is 0.32mg, let it stand for 100h, take the supernatant and filter, medicine The slag is decocted in water and alcoholized, filtered, and the ethanol is recovered...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating level-1 and level-2 hypertension and a preparation method of the composition. The traditional Chinese medicine composition for treating level-1 and level-2 hypertension is characterized by comprising the following raw medical materials: ligusticum wallichii, rhizoma alismatis, semen raphani, seaweed and leech; and the traditional Chinese medicine composition is prepared through the steps of decocting, carrying out alcohol precipitation and the like for the raw medicinal liquid with the preparation amount. The traditional Chinese medicine composition has remarkable therapeutic effects on the level-1 and level-2 hypertension, not only reduces blood pressure, but also improves blood grease level of a patient and the hemorheology, increases a heart function, and is good for correcting disordered lipid metabolism of the patient. The preparation method is simple and good for production, and has no side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating grade 1 and grade 2 hypertension and a preparation method thereof. Background technique [0002] Hypertension is a systemic disease whose cause has not been fully elucidated, characterized by increased systemic arterial pressure, and may be accompanied by functional or organic changes in the heart, blood vessels, brain, and kidneys. The greatest harm of high blood pressure is the occurrence of cardiovascular disease. At present, the number of hypertensive patients in the world is about 1.2 billion. Among hypertensive patients aged 40 to 70, every 20mmHg increase in systolic blood pressure or 10mmHg increase in diastolic blood pressure doubles the risk of cardiovascular disease. Over the past half century, the prevalence of hypertension in the Chinese population has risen rapidly....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61P9/12A61K35/62
Inventor 韩学杰沈绍功
Owner INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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