Method for preparing film agent by using chitosan and Arabic gum as matrix

A technology of gum arabic and chitosan, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve long-term use irritation, incomplete drug release, and poor absorption effect and other issues, to achieve the effects of low price, improved bioavailability, and simple and economical preparation process

Inactive Publication Date: 2013-06-05
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem of poor absorption effect of existing film preparations, or incomplete drug release with high residual amo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0015] Specific embodiment one: a kind of preparation method of the film preparation of matrix with chitosan and gum arabic of the present embodiment is to carry out according to the following steps:

[0016] 1. Dissolve 1-5g of chitosan in 100mL of acetic acid solution with a mass concentration of 1%-10%, heat in a water bath at a temperature of 50-55°C, and stir until dissolved to obtain a chitosan solution;

[0017] 2. Dissolving 1 to 20 g of gum arabic in 100 mL of acetic acid solution with a mass concentration of 1% to 10%, heating in a water bath at a temperature of 80 to 85°C, and stirring until dissolved, to prepare a gum arabic solution;

[0018] 3. Mix the chitosan solution prepared in step 1 with the gum arabic solution prepared in step 2 to obtain a mixed solution, heat the mixed solution at a temperature of 30-70° C., and add 0.1-20 g of medicine, 0.1-10mL of plasticizer and 0.1-10mL of absorption accelerator are stirred to obtain a mixture, and then the mixture i...

specific Embodiment approach 2

[0024] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that in step 1, the temperature is 50° C. and heated in a water bath. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0025] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in step 2, the temperature is 80° C. and heated in a water bath. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a method for preparing a film agent by using chitosan and Arabic gum as matrix, and relates to a preparation method of the film agent. With the adoption of the method for preparing the film agent by using the chitosan and the Arabic gum as the matrix, the problem that the conventional film agent is poor in absorption effect, or has high drug-release incomplete residual amount, or has irritation in long-term use can be solved. The preparation method provided by the invention comprises the steps of I, preparing a chitosan solution; II, preparing an Arabic gum solution; and III, mixing the chitosan solution prepared by the step I with the Arabic gum solution prepared by the step II, so as to obtain a mixed solution; heating the mixed solution; stirring after adding drugs, a plasticizer and an absorption promoter, so as to obtain a mixture; and then preparing the film agent by using the mixture through a film coating machine. The film agent is a film agent using the chitosan and the Arabic gum as the matrix. The film agent prepared by the invention has the advantages of low drug residual amount and slight irritation; the biological use rate is improved; the simple preparation process and the temperate conditions can be realized; and the desired raw auxiliary materials are cheap and easy to get. The method for preparing the film agent by using the chitosan and the Arabic gum as the matrix provided by the invention is applied to the field of preparing a pharmaceutical preparation.

Description

technical field [0001] The invention relates to a preparation method of a film agent. Background technique [0002] Chitosan is a white or light yellow translucent solid with a slight pearly luster. Under acidic conditions, the amino groups in the molecule combine with protons to make itself positively charged. Therefore, chitosan is a highly positively charged polysaccharide rare in natural polysaccharides. Molecular matter. In addition, chitosan has good chemical stability, but it has strong hygroscopicity and is easy to decompose when exposed to water; it is non-toxic and harmless, has excellent biocompatibility, can be dissolved by lysozyme, etc., and is biodegradable, and its metabolites are non-toxic. And can be completely absorbed by organisms. [0003] Ordinary gums can be saturated by adding up to 5-8% in the process of dissolving in water, while the mixing ratio of gum arabic and water can be as high as 55%, and can have very high viscosity performance when the c...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/36A61K45/00
Inventor 李强赵学玲王国志龚显峰张华
Owner HEILONGJIANG UNIV
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