Method for preparing film agent by using chitosan and Arabic gum as matrix

Abstract

The invention provides a method for preparing a film agent by using chitosan and Arabic gum as matrix, and relates to a preparation method of the film agent. With the adoption of the method for preparing the film agent by using the chitosan and the Arabic gum as the matrix, the problem that the conventional film agent is poor in absorption effect, or has high drug-release incomplete residual amount, or has irritation in long-term use can be solved. The preparation method provided by the invention comprises the steps of I, preparing a chitosan solution; II, preparing an Arabic gum solution; and III, mixing the chitosan solution prepared by the step I with the Arabic gum solution prepared by the step II, so as to obtain a mixed solution; heating the mixed solution; stirring after adding drugs, a plasticizer and an absorption promoter, so as to obtain a mixture; and then preparing the film agent by using the mixture through a film coating machine. The film agent is a film agent using the chitosan and the Arabic gum as the matrix. The film agent prepared by the invention has the advantages of low drug residual amount and slight irritation; the biological use rate is improved; the simple preparation process and the temperate conditions can be realized; and the desired raw auxiliary materials are cheap and easy to get. The method for preparing the film agent by using the chitosan and the Arabic gum as the matrix provided by the invention is applied to the field of preparing a pharmaceutical preparation.

Description

technical field [0001] The invention relates to a preparation method of a film agent. Background technique [0002] Chitosan is a white or light yellow translucent solid with a slight pearly luster. Under acidic conditions, the amino groups in the molecule combine with protons to make itself positively charged. Therefore, chitosan is a highly positively charged polysaccharide rare in natural polysaccharides. Molecular matter. In addition, chitosan has good chemical stability, but it has strong hygroscopicity and is easy to decompose when exposed to water; it is non-toxic and harmless, has excellent biocompatibility, can be dissolved by lysozyme, etc., and is biodegradable, and its metabolites are non-toxic. And can be completely absorbed by organisms. [0003] Ordinary gums can be saturated by adding up to 5-8% in the process of dissolving in water, while the mixing ratio of gum arabic and water can be as high as 55%, and can have very high viscosity performance when the c...

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem of poor absorption effect of existing film preparations, or incomplete drug release with high residual amount, or irritating problems during long-term use, thereby providing a chitosan and gum arabic gum as matrix The preparation method of the film preparation method