Preparation method of aescin

A technique for aescin and horse chestnut, which is applied in the field of preparation of aescin, can solve the problems of few medicinal material resources, low content of aescin, troubled scientific researchers and the like

Active Publication Date: 2013-06-05
南京宏冠生物科技有限公司
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, people have been cutting down a lot of horse chestnuts for a long time, resulting in less and less existing medicinal resources, and now the content of medicinal resources has also dropped a lot, and the content of the best raw materials is only about 7-8%. In the prior art, there are problems of limited resources of raw medicinal materials and low content of aescin, which have always been problems for scientific researchers.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The invention discloses a preparation method of aescin, which uses the fruit of horse chestnut as a raw material, and undergoes crushing, extraction, concentration, resin adsorption, and elution of impurities to obtain aescin.

[0019] (1) The crushing process is as follows: 2000Kg of horse chestnut fruit is screened out, and then crushed to 10mm particles.

[0020] (2) The extraction process is as follows: add 91% ethanol in three times according to the mass multiple of the horse chestnut fruit, 4 times, and 2 times, and extract three times, that is, add 90% ethanol three times for 8000Kg, 8000Kg, 4000Kg respectively , respectively collected two or three extracts, the extraction time was 2.0h, 2.0h, 2.0h respectively, and the extraction temperature was 80°C, the first extract was concentrated to obtain 20.12% aescin

[0021] (3) The process of concentration is as follows: mix the extracts collected in two or three extractions in the extraction process, and concentrate ...

Embodiment 2

[0028] The invention discloses a preparation method of aescin, which uses the fruit of horse chestnut as a raw material, and undergoes crushing, extraction, concentration, resin adsorption, and elution of impurities to obtain aescin.

[0029] (1) The crushing process is as follows: Screen out 2000Kg of horse chestnut fruit, and then crush it to 15mm particles.

[0030] (2) The extraction process is as follows: add 90% ethanol in three times according to the mass multiple of the horse chestnut fruit, 3.5 times, 3.5 times, and 3 times, and extract three times, that is, add 85% ethanol three times for 7000Kg, 7000Kg, 6000Kg respectively , respectively collect two or three extracts, the extraction time is 2.0h, 1.5h, 1.5h, the extraction temperature is 76°C, 76°C, 85°C respectively, the first extract is concentrated to obtain 20.05% aescin

[0031] (3) The process of concentration is as follows: mix the extracts collected in two or three extractions in the extraction process, and ...

Embodiment 3

[0038] The invention discloses a preparation method of aescin, which uses the fruit of horse chestnut as a raw material, and undergoes crushing, extraction, concentration, resin adsorption, and elution of impurities to obtain aescin.

[0039] (1) The crushing process is as follows: 2000Kg of horse chestnut fruit is screened out, and then crushed to 5mm particles.

[0040] (2) The extraction process is as follows: add 92% ethanol in three times according to the mass multiple of the horse chestnut fruit, 5 times, 3 times, and 2 times, and extract three times, that is, adding 92% ethanol three times is 10000Kg, 6000Kg, 4000Kg respectively , respectively collected two or three extracts, the extraction time was 2.5h, 2.0h, 1.5h, the extraction temperature was 80°C, 80°C, 85°C respectively, the first extract was concentrated to obtain 21.91% aescin

[0041] (3) The process of concentration is as follows: mix the extracts collected from two or three extractions in the extraction proc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a preparation method of aescin. According to the invention, the fruit of horse chestnut is adopted as a raw material, and is subjected to crushing, extracting, concentrating, resin absorbing, and impurity eluting, such that aescin is obtained. Compared with prior arts, the method provided by the invention is simple and is easy to operate. Aescin content in first-time extraction can be higher than 20%, and the aescin content in the entire extraction process is gradually improved. After final extraction, the content can be higher than 88%. According to the invention, aescin extraction is carried out with limited raw material source, and a problem of low aescin content is solved. The method is suitable for industrialized productions.

Description

technical field [0001] The invention relates to a preparation method of aescin. Background technique [0002] Aescin is the fruit extract of Aesculus aesculus. It has anti-tissue edema, reduces vascular permeability, prevents water accumulation in tissues, and quickly eliminates the heavy feeling and pressure caused by local edema. It can treat stomach cold pain, abdominal fullness, malnutrition, malaria, and dysentery. However, people have been cutting down a lot of horse chestnuts for a long time, resulting in less and less existing medicinal resources, and now the content of medicinal resources has also dropped a lot, and the content of the best raw materials is only about 7-8%. In the prior art, there are problems of limited resources of raw medicinal materials and low content of aescin, which have always been problems for scientific researchers. Contents of the invention [0003] The present invention proposes a method for preparing aescin, which solves the deficien...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/08
Inventor 王恕
Owner 南京宏冠生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products