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Anti-acquired immune deficiency syndrome composition rutin sodium sulfonate composite process

A technology of sodium rutinsulfonate and synthesis process, applied in the directions of sugar derivatives, sugar derivatives, organic chemistry, etc., can solve problems such as unreported synthesis process of sodium rutinsulfonate

Inactive Publication Date: 2013-06-12
陕西惠丰制药有限公司
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  • Summary
  • Abstract
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  • Application Information

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Problems solved by technology

[0005] At present, there is no report about the synthetic technique of sodium rutinsulfonate

Method used

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  • Anti-acquired immune deficiency syndrome composition rutin sodium sulfonate composite process

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Embodiment Construction

[0008] Method 1: Weigh 50g of refined rutin into a 500mL three-necked bottle, add 100-150mL of glacial acetic acid, add 200-240mL of acetic anhydride, and drop a mixture of concentrated sulfuric acid and glacial acetic acid (1:1) at 10°C for 120 ~150mL, stirred and reacted for 2~3h, poured the reaction solution into 500mL saturated sodium chloride solution, stirred thoroughly, left for 1h, precipitated and filtered, dried at 50~60°C for 8~12h. Obtain crude sodium rutinsulfonate. Dissolve the crude product in 99% methanol, add liquid caustic soda to adjust the pH to 6.5-7.0, filter, add 3-5 g of activated carbon to the filtrate and heat it for 20 minutes under slight boiling, filter, concentrate the filtrate under reduced pressure to remove 70% methanol, crystallize for 24 hours, filter, After drying, 54.8 g of refined sodium rutinsulfonate was obtained.

[0009] Method 2: Weigh 20g of refined rutin into a 200mL three-necked flask, add 80-120mL of thionyl chloride, place in an...

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Abstract

Provided is an anti-acquired immune deficiency syndrome composition rutin sodium sulfonate composite process. The anti-acquired immune deficiency syndrome composition rutin sodium sulfonate composite process is two types of processes which use rutin as raw materials, and acquire rutin sodium sulfonate composition through two reagents of concentrated sulfuric acid and chlorosulfonic acid.

Description

technical field [0001] The invention relates to a synthesis process of anti-AIDS compound sodium rutinsulfonate Background technique [0002] Rutin is a plant-derived flavonol diglycoside compound, which becomes sodium rutin sulfonate (SRS) after sulfate esterification, and studies have shown that it has anti-HIV activity. At present, there is no microbicide on the market in the world, and there are 5 compounds that have entered the third phase of clinical trials, and sodium rutin sulfate (sodium rutin sulfate, SRS) is one of them. Its structural formula is as follows: [0003] [0004] Sexual transmission is the most important way of HIV infection. AIDS seriously endangers human health. The development of anti-HIV drugs can reduce the morbidity and mortality of HIV / AIDS. At present, 90% of the infected people in the world are infected with HIV virus through sexual transmission, and the proportion of female infected people is gradually increasing. In 2005, 49.8% of new...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/00
Inventor 李玉山
Owner 陕西惠丰制药有限公司