Production process for extracting high-purity birutan from flos sophora

Abstract

The invention discloses a production process for extracting high-purity rutin from bud of Chinese scholartree. The process mainly comprises the following steps: selecting clean bud of Chinese scholartree, crushing the bud of Chinese scholartree, percolating the bud of Chinese scholartree through a dissolvent, carrying out the acid precipitation of the filtrate, and drying the filtrate, so as to obtain crude rutin; dissolving the crude rutin in saturated ferric ammonium citrate solution, putting the solution in water bath at a temperature between 40 and 50 DEG C; and stirring the solution for 30 minutes, filtrating, cooling down the solution through standing, then carrying out acid precipitation and suction filtration, cleaning the filter residue through purified water to reach neutrality, and drying the filter residue, so as to obtain the refined rutin. The production process has the advantages that ferric ammonium citrate is taken as the flux of rutin, thereby polymerizing the ferric ammonium citrate molecule and the ortho-phenolic hydroxyl in the rutin molecule, ensuring that the planar structure of the rutin molecule is polymerized into a heterocycle-shaped complex steric structure, reducing the mutual polymerization of the rutin molecules, and greatly improving the solubility of the rutin in water; the production process not only has high yield and purity, but also has simple technology and low manufacturing cost.

Description

technical field [0001] The invention relates to a production process for extracting medicinal components from Chinese medicinal materials, in particular to a production process for extracting high-purity rutin from Sophora japonica. Background technique [0002] Rutin, synonymous with rutin, is yellow or yellow-green powder, or very fine needle-shaped crystals; odorless, tasteless, gradually darkens in the air; heated to 185-192 ° C into a brown gel. Rutin in production is mainly plant raw material extracted from Sophora japonica (the dry flower bud of Sophora japonica tree). It has the effect of reducing the abnormal permeability and fragility of capillaries. It is mainly used as an adjuvant therapy for the prevention and treatment of hypertension. At the same time, it has anti-inflammatory and vitamin P-like effects. It is also used clinically for cerebral hemorrhage, retinal hemorrhage, hemorrhagic purpura, acute hemorrhagic nephritis, and traumatic pulmonary hemorrhage...

AI Technical Summary

Problems solved by technology

[0003] Since rutin belongs to flavonoids and is almost insoluble in water and fat, the technologies currently used in my country to extract rutin from Sophora japonica include hydrothermal extraction, hot alkali extraction, and methanol thermal extraction, etc., but they have fatal Weaknesses: First, the yield is low, the content is low, and there are many impurities, so its medicinal effect is not obvious

The second is that the production process is complicated, the production cost is high, the impurities cannot be completely removed and the purity is not high, the adverse reactions are serious, and it cannot meet the international quality standards, especially the requirements of the German standard (DAB-96 version), so almost all Chinese Sophorae rice is exported to Japan , and rutin has always been a monopoly product in Japan

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