Method for removing free sulphur in enoxaparin sodium raw material

Abstract

The invention discloses a method for removing free sulphur in an enoxaparin sodium raw material, and belongs to the field of biological medicines. The method comprises the following steps of: removing free sulphur in the enoxaparin sodium raw material through adopting a circulation ultrafiltration method, so as to satisfy quality requirements on controlling the free sulphur content in the enoxaparin sodium raw material. Compared with the prior art, the method has the characteristics of safety, high efficiency, convenience in large-scale industrial production and the like as well as good popularization and application values.

Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a method for removing free sulfur (Free Sulphate) in enoxaparin sodium raw materials. Background technique

[0002] Heparin drugs are the first choice of anticoagulant drugs. They have been used for more than 70 years. In addition to anticoagulant and antithrombotic effects, they also have blood lipid-lowering effects, but they have defects such as low bioavailability and large side effects. Clinical application of heparin. In recent years, a new generation of anticoagulant drugs with high antithrombotic activity and low bleeding side effects - low molecular weight heparin (LMWH) has been developed and marketed. The antithrombotic effect of the new generation of anticoagulant drugs is better than that of heparin, but the anticoagulant effect is lower than that of heparin, and has the characteristics of high bioavailability, long half-life in vivo, small bleeding tendency, and easy abs...

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