98results about How to "Easy to realize industrialized mass production" patented technology

The invention discloses a compound chicory series product and a preparation method thereof. The series product is prepared from main component chicory and one or more yam rhizome, semen coicis, rhizoma smilacis glabrae, Siegesbeckia herb, longhairy antenoron herb, cutch, mulberry leaf, kudzu-vine root, barbary wolfberry fruit, poria cocos, corn stigma, guava leaf, red yeast rice, cassia seed, hawthorn, lotus leaf, aloe and nano selenium according to different applications of the product. The product has the main characteristics of synchronous adjusting effect on endocrine disorder and obvious effects on adjustment of blood uric acid, blood sugar and blood fat and immunity reinforcement, wide adaptive crowd and positive economic and social significance and is easy to realize industrialized large production.

The invention discloses a body structure of a boiling rotating fluidized bed, which comprises an outer housing and an air distributor. Due to the coverage of the outer housing and the air distributor, an accommodation chamber of the fluidized bed is formed. The air distributor is like a groove and tilts from the feeding end of the bed body to the discharging end. The air distributor mainly comprises an air distributor bottom board configured in the middle and air distributor sideboards configured on the two sides. A blowing bottom hole communicated with a sectionalized wind box is configured on the air distributor bottom board, and a blowing side hole communicated with the sectionalized wind box is configured on the air distributor sideboard. The air distributor is tooth-shaped or wave-shaped, the blowing bottom hole is configured between the teeth of a tooth-shaped air distributor bottom board or at the wave trough of a wave-shaped air distributor bottom board, and the opening of the blowing bottom hole faces the discharging end of the bed body. The opening of the blowing side hole on the air distributor sideboard faces the air distributor bottom board. The invention has the advantages of simple body structure, smooth bed surface and optimized flow field and can greatly improve the boiling rotating fluidized status. In addition, the invention can reduce more energy consumption.

The invention discloses a tacrolimus eye ointment for cornea transplantation and a preparation method thereof, belongs to the field of pharmaceutical preparation and particularly relates to a tacrolimus eye precursor vesicle capsule for cornea transplantation and a preparation method thereof. The precursor vesicle capsule comprises the following raw materials in percentage by weight: 0.04-0.8% of tacrolimus, 4.0-41.0% of surfactant, 1.6-8.0% of cholesterol, 4.0-41.0% of lecithin, 1.2-30.% of alcohol, and the balance of water or 0,1% of glycerol aqueous solution or phosphate buffer with PH of 7.4, wherein the surfactant is one of span, tween, polyoxyethylene ether castor oil and poloxamer, and the alcohol is one of ethanol, isopropanol, butanol and propanol. The tacrolimus precursor vesicle capsule has limited moisture, and the storage stability of the preparation can be improved; the product organically combines the advantages of the precursor vesicle capsule, the characteristics of an eye dosing system and the indication disease of the tacrolimus drugs, so as to achieve the advantages of improving the curative effect, reducing the side effect, and bringing convenience in administration; and the preparation technique is simple and convenient and is suitable for industrial production.

The invention relates to a cellophane direct flotation collecting agent and a method for preparing the cellophane direct flotation collecting agent, in particular to a novel cellophane direct flotation collecting agent which is formed by modification and compounding of fatty acid and the like. The method for preparing the cellophane direct flotation collecting agent comprises the steps that by weight, 20%-80% of cotton oil residues and 10%-60% of higher fatty acid are respectively added to a reaction still, strong base solution with any concentration is slowly added to the reaction still, the use amount of strong base is 5%-20% within the temperature of 60DEG C-150DEG C, the solution in the reaction still is well stirred at the speed of 500-2500rad / min, is cooled to the temperature of 60DEG C or so, then 0-20% of chlorinated fatty citric acid acids ester is added to the solution and the solution is well stirred, and accordingly the cellophane direct flotation collecting agent is obtained. The cellophane direct flotation collecting agent is high in selectivity and cellophane-carrying capability, has good sorting effect under a normal temperature, and can reach an excellent flotation index.

The invention relates to a scandium oxide-stabilizing zirconia powder and a preparation method thereof. The scandium oxide-stabilizing zirconia powder comprises zirconium oxychloride as precursor mother salt, one or more third elements of aluminum oxide, cerium oxide and bismuth oxide and a doping system, wherein the doping quantity of the scandium oxide is 8 mol%, and the total doping quantity of the aluminum oxide, the cerium oxide and the bismuth oxide is 0-7 wt%. The preparation method comprises the steps of water washing, filtration, drying, calcinations and powder surface dry and wet modification as well as constant-pressure hydrolysis reaction and low-pressure hydro-thermal reaction, wherein the constant-pressure hydrolysis reaction and low-pressure hydro-thermal reaction are carried out by the steps of: firstly carrying out constant-pressure hydrolysis on a water solution of the precursor mother salt ZrOCl2 (ScCl3) in a reactor, and then carrying out hydro-thermal treatment on hydrolysis liquid at the temperature less than 150 DEG C and the pressure of 0.3-0.5 MPa. The scandium oxide-stabilizing zirconia powder has the characteristics of small grain size, centralized size distribution, high sintering activity, lower specific surface area, suitability for the traditional casting process of a SOFC (Solid Oxide Fuel Cell) and high conductivity and strength index, and the preparation method has the advantages of simple and safe production process, lower cost, low requirement for equipment and easy realization of industrial big production.

The invention relates to an explosion welding method of composite steel plate and relative application in linear motor, wherein said method comprises that: 1, matching that: coupling the conductive metal plate with steel plate; 2, abrading surface and coating protective layer that cleaning the face of steel plate that contacts the metal plate and coating protective layer at the explosive contact face; 3, exploding and welding that welding the steel plate with metal plate via explosion; 4, aligning that aligning the composite steel plate on aligning machine; 5, finishing that finishing the concaves on the face caused by explosion. And the inventive composite steel plate can be mounted on the sensitive plate mounting base of subway to form sensitive plate of linear motor rotor. The combine rate of composite steel plate can reach 99. 5%, with low cost.

The invention relates to Cacumen Platycladi polyphenol capable of reducing activity of uric acid, and a preparation method and application of the Cacumen Platycladi polyphenol. The Cacumen Platycladi polyphenol is obtained by ultra-high-pressure leaching, normal-pressure high-temperature leaching, filtration concentration and macroporous adsorption resin purification. The Cacumen Platycladi polyphenol is high in safety and high in thermal stability. A xanthine oxidase inhivitory activity test proves that the Cacumen Platycladi polyphenol has good uric acid reducing activity, and can be used for preparing functional foods with a uric acid reducing effect or assistant treatment medicines for diseases such as hyperuricemia and gout. A preparation technology is reasonable, simple and environment-friendly, and the Cacumen Platycladi polyphenol is easy to produce widely and industrially.

The invention relates to a Stauntonia brachyanthera Hand-Mazz component as well as a preparation method and application thereof, belonging to the technical field of medicines. The method comprises the following steps of: extracting Stauntonia brachyanthera Hand-Mazz by using water or organic solvents with different concentrations, filtering and recovering the solvents to obtain a concentrated solution; eluting the concentrated solution by using water and an organic solvent through macroporous absorption resin, recovering the solvent to obtain a saponin, or obtaining the saponin from an n-butyl alcohol layer by using an extracting method; then further separating and purifying the saponin by using a normal-phase silicagel column, a reversed phase column and a high efficient liquid phase preparation system; and finally obtaining a monomer or compound with remarkable activity. The Stauntonia brachyanthera Hand-Mazz component of the invention can be singly or combined with other drugs to be used as a raw drug applied to a drug for resisting tumour, resisting inflammation, promoting urination, and treating other diseases. The Stauntonia brachyanthera Hand-Mazz component prepared with the method has high purity, remarkable pharmacological action, simple and convenient method, practicability, low price, safety, suitability for industrialized production.

The invention discloses a diindolefiredamp derivant preparing method, which comprises the following steps: using carbinol or alcohol for reaction solvent; carrying on electrophilic reaction with indole and aldehyde for 0.1-5 hours catalyzing by tetranbutyl ammonium tribromide; getting high yield of diindolefiredamp derivant, wherein the mole equivalent weight ratio of indole and aldehyde is 1.8-2.2: 1; the dosage of accelerant tetranbutyl ammonium tribromide is 1-10% mole equivalent weight of indole. The invention has mild conditioned response, which is easy for throwing material and after-treatment.

The invention relates to the technical field of battery materials and in particular relates to a preparation method of modified lithium titanate. The modified lithium titanate comprises a lithium source, a titanium source, a carbon source and a molybdenum source. A preparation process of the modified lithium titanate comprises the following steps of: mixing the lithium source, the titanium source, the molybdenum source and the carbon source, and performing ball milling; and calcining the mixture obtained through ball milling at 400-1,000 DEG C for 6-20 hours in the presence of inert gas in a tubular furnace. The modified lithium titanate is stable in performance and good in consistency; the preparation method is low in cost and simple in process, and can be applied to large-scale industrial production; and the obtained product is charged and discharged at 5C multiplying power, and the capacity is still as high as 118 mAh / g after 200 times of circulation.

The invention discloses a Niraparib synthesis method. The method comprises that through esterification, 3-methyl hydroformylation, 3-schiff base reaction, cyclization, amidation, BOC removal and chiral resolution, optically pure Niraparib with purity of 91% or more is prepared from 3-methyl-2-nitrobenzoic acid. The method has the advantages of simple process, high efficiency, easy operation and less equipment requirement, and is a method suitable for industrial production.

The invention discloses AlF3, and a preparation method and an application thereof. The preparation method includes: 1) heating an aluminum salt solution and adding a fluoride salt to form a mixed solution; 2) heating and crystallizing the mixed solution to obtain a precursor; 3) calcining the precursor to obtain the AlF3, wherein the aluminum salt and fluoride salt are both soluble. The preparation method is abundant in raw material source, is low in cost, is simple and reliable, has gentle reaction conditions and is easy to carry out in large-scale industrial production. Secondly, the methodis free of HF, so that the method is more environment-friendly and safe. Meanwhile, the AlF3 has excellent electrochemical performance, so that when being applied to batteries as a cathode active material, the AlF3 can reach 2.8-3.1 V in initial voltage and is higher than 300 mAh / g in specific capacity. Finally, the AlF3 has a special globular flower appearance.

Provided is a super-wear-resistant long-acting antibacterial and antiviral nano-coating comprising the components in parts by weight: 30 to 75 parts of composite silicate, 2 to 6 parts of an antibacterial agent, 1 to 3 parts of an antiviral agent, 1 to 3 parts of a defoamer, 1 to 3 parts of a leveling agent and 150 to 350 parts of deionized water. Silver ions can be slowly and controllably released from the interior of the coating layer continuously, so that rapid and long-term antibacterial ability is obtained; a pure inorganic component coating layer is formed through a Sol-Gel reaction of lithium silicate and potassium silicate, and the coating layer is non-toxic and harmless, has ultrahigh hardness and wear resistance, and also has the characteristics of easiness in cleaning and fingerprint resistance; the preparation method is simple and good in repeatability, and industrial large-scale production is easy to realize.

A method for preparing large graphene sheets in large scale includes steps of: under a mild condition, processing graphite powders with intercalation through an acid and an oxidant; washing away metal ions and inorganic ions in the graphite powders with dilute hydrochloric acid, then filtering and drying; and, finally processing with a heat treatment. The present invention breaks through a series of bottlenecks restricting an efficient preparation of graphene that result from a traditional method of using large amounts of deionized water to wash graphite oxide to be neutral, and easily realizes a batch production. A radial scale of the prepared graphene sheets is distributed from 20 um to 200 um.

The invention relates to a cellophane positive flotation collector and a preparation method of the cellophane positive flotation collector, in particular to a cellophane positive flotation collector compounded by fatty acid and the like, wherein the basic substances comprise the following preparation raw materials in percentage by weight: 30 to 80 percent of chlorinated oleic acid, 5 percent to 60 percent of saturated higher aliphatic acid, 5 percent to 40 percent of unsaturated higher aliphatic acid and 5 percent to 20 percent of alkali, the saturated higher aliphatic acid is one of materials from tetradecanoic acid, stearic acid and palmitic acid, and the unsaturated higher aliphatic acid is one of materials from oleic acid, coconut oil and linoleic acid. By aiming at the Yunnan phosphorite characteristic, the positive flotation collector has high selectivity and high mine carrying capability, the better sorting effect is realized at the normal temperature, and excellent flotation indexes can be reached. By aiming at the refractory cellophane, the comprehensive mineral dressing efficiency and the recovery rate of phosphate concentrate after the flotation are higher.

The invention provides a novel non-woven fabric with high bacteriostatic performance. The novel non-woven fabric is prepared from the following raw materials by weight: 100 to 120 parts of antibacterial polypropylene, 40 to 60 parts of nylon 6, 20 to 40 parts of titanium dioxide-cobaltous phosphate, 10 to 20 parts of a coupling agent and 30 to 50 parts of auxiliary agents consisting of antimony oxide, red phosphorus, aluminum oxide, an anti-oxidant, an ultraviolet absorbent and a plasticizer. The novel non-woven fabric prepared in the invention has more stable antibacterial properties, is non-volatile, long in service life and easy to process and store, does not penetrate into the epidermis of human beings or animals, shows excellent antibacterial effect on specific bacterial strains and has special effects on molds; and through synergism with an inorganic antibacterial agent, the novel non-woven fabric has good safety, heat resistance, sustained-release performance, a broad antibacterial spectrum and small possibility of generating drug resistance.

The invention provides a thermal barrier coating containing YAG: Ce and a preparation method and application thereof, and relates to the technical field of thermal barrier coatings. The thermal barrier coating containing YAG: Ce comprises a metal bonding layer, a fluorescent stress sensing layer and a ceramic layer, wherein the metal bonding layer, the fluorescent stress sensing layer and the ceramic layer are sequentially arranged in a stacked mode; the metal bonding layer is used for gluing an alloy substrate of a test piece, and the fluorescent stress sensing layer is mainly prepared from YAG: Ce powder through spraying. The technical problem that the stress-frequency shift factor sensitivity of a traditional Eu-doped thermal barrier coating is poor, and consequentially, the stress within 0.1 GPa cannot be accurately measured is solved, and accurate measurement of the stress within 0.1 GPa on a key interface in the thermal barrier coating is achieved. According to the thermal barrier coating containing YAG: Ce, the measurement precision of the stress in the thermal barrier coating can be effectively improved, eerily monitoring of the internal stress evolution is achieved, and thus, the safe service life of the thermal barrier coating can be comprehensively, effectively and accurately predicted.

The invention discloses a production process for a biphenylnitrile type liquid crystal material. The production process comprises the following steps: firstly, reacting 4-N-alkyl halogenated benzene or 4-N-alkoxy halogenated benzene and metal magnesium powder in tetrahydrofuran under the protection of nitrogen gas to obtain a corresponding tetrahydrofuran solution of a Grignard reagent; secondly, dropping the tetrahydrofuran solution of the Grignard reagent into the tetrahydrofuran mixed solution containing a coupling reaction catalyst and 4-halogen-substitued cyanophenyl; after the reaction is ended, filtering and recovering metal salts; distilling to recover the solvent; carrying out rectification under vacuum and clay bleaching; and respectively recrystalizing with normal heptane and ethanol as solvent to obtain the biphenylnitrile type liquid crystal material. The production process disclosed by the invention has the advantages of low-priced and easily-accessible raw material, simple reaction, high yield, favorable quality of products, low production cost and the like, and is suitable for industrial production of biphenylnitrile type liquid crystal products.

The invention discloses a method for preparing betaine hydrochloride. In the method, chloroacetic acid, trimethylamine and a water removing agent are used as raw materials and reacted in an organic solvent to prepare the betaine hydrochloride. The method comprises the following specific processing steps: putting the organic solvent into a reaction kettle; starting the reaction kettle to stir the organic solvent; adding the chloroacetic acid and the water removing agent and introducing the trimethylamine for reaction at a certain temperature; and after the reaction is finished, cooling, crystallizing, centrifuging, cleaning and drying to obtain the betaine hydrochloride. The method has the advantages of reduction in production cost because two raw materials are saved, no other by-products in the product, no waste discharge, reduction in energy consumption, simple process, short production period, mild reaction condition, easy realization of big industrial production, stable product quality, and recyclable raw materials and solvent.

The invention discloses a method for dissolving cellulose, characterized by: using at least one from the group consisting of wood pulp, cotton pulp, hemp pulp, bamboo pulp, bagasse pulp, grass fibered pulp, cellulose non-woven fabric or steam exploded cellulose pulp as cellulose raw material, uniformly stirring the cellulose raw material, NaOH and water at a temperature of -15-50 DEG C to obtain a cellulose solution. The prepared cellulose concentrated solution has good spinnability and film forming property. The method breaks through a dissolution method of traditional gluing technology, does not relate to carbon disulfide and other substance causing serious environmental pollution, and is green and environmentally friendly. According to the invention, the cellulose raw material can be directly rapidly dissolved at room temperature, without heating or precooling a solvent. The method has the advantages of saving energy, and reducing energy consumption. By using raw materials having low cost, the method has the advantages of simple operation, small investment, high productivity, and is easy to realize large-scale industrial production.

The invention discloses a synthesizing method of N, N'-diisopropyl thiourea, which comprises the following steps: adopting water as reacting solvent and 2-10% PEG-400 as catalyst; reacting thiourea and diisopropylamine with molar rate at 0.4-0.6: 1 under normal pressure to reflux for 20-36h; filtering; washing; separating to obtain the product.

The invention discloses a super-gravity hydrothermal reaction device which comprises a centrifugal apparatus, a temperature-control furnace and an autoclave, wherein the centrifugal apparatus comprises an electric motor, a rotation shaft, a centrifugal bracket, a cooling pipe and an anti-explosion cylinder, and the cooling pipe is wound outside the rotation shaft and the electric motor; the temperature-control furnace comprises a heating wire, insulating ceramics, an insulating brick and a shell, and the heating wire is wound inside the insulating ceramics; the rotation shaft in the centrifugal apparatus stretches into the middle part of the cavity of the temperature-control furnace from the bottom of the temperature-control furnace, and the centrifugal bracket of the centrifugal apparatus is fixed on the rotation shaft; the autoclave is connected with the centrifugal bracket of the centrifugal apparatus by means of snap rings; and the anti-explosion cylinder of the centrifugal apparatus is installed in the inner wall of the cavity or between the inner wall of the cavity and the shell of a furnace. The device provided by the invention has the advantages of both supergravity and hydrothermal reaction, thus being suitable for preparing various materials with special functions and structures.

The invention discloses a synthetic method for preparing Niraparib. According to the method, optically pure Niraparib which is 91 percent or more in purity is prepared by performing esterification, 3-methyl hydroformylation, Schiff Base reaction, cyclization, amidation, BOC deprotection and chiral separation on 3-methyl-2-nitrobenzoic acid serving as an initial raw material. The method is simple, is high in efficiency, is easy to operate, is low in equipment requirement, and is suitable for industrial production.

The invention provides a preparation method and application of a highland barley beta-glucan extract. The preparation method comprises the following steps: (1) pretreatment of highland barley: dryingthe highland barley at 50-70 DEG C, crushing the highland barley and conducting sieving with a screen having a pore diameter of 0.5-1.5 mm; (2) water extraction of the pretreated highland barley: under the condition that a solid-liquid ratio m / m is 1: 10 to 1: 80, adjusting a pH value to 7-8, adding lipase accounting for 0.01-0.10 wt% of the water amount of a solvent, conducting reacting at 40-60DEG C for 1-5 hours, adjusting the pH value to 5-6, adding pectinase accounting for 0.01-0.10 wt% of the amount of the solvent, and performing reacting at 50-60 DEG C for 1-5 hours; and (3) solid-liquid separation for preparation of a coarse filtrate. According to the preparation method, the extraction rate of highland barley beta-glucan is increased, and the stability of the extract can be improved; and experiments prove that the obtained beta-glucan extract has good effects of scavenging free radicals and preventing radiation.

The invention provides an externally applied gel for treating gout, which is an externally applied medicine made from traditional Chinese medicine components such as nidus vespae, colchicine, a gel matrix, and the like., and by taking a coupling medium as transdermal carrier. The anti-gout gel can quickly eliminate redness, swelling, pain and fever symptoms of gouty arthritis, inhibit granulocyte infiltration and formation of lactic acid, reduce synthesis of uric acid, shorten and stop the acute attack of the gouty arthritis, prevent gout complications that threaten life, suspend tissue and organ damage caused by deposition of the uric acid, thus ensure that the illness of a patient is stabilized and can not deteriorate anymore for a long time. With the coupling medium adopted as the transdermal carrier of the medicine, the gel is characterized in that: a dermal hydration gradient can be naturally formed in the skin permeation course of the coupling medium, the gradient is independent of concentration when driving osmotic pressure difference, the gel has high deformability, can keep the components thereof unchanged after the skin permeation course and can permeate corneum of mammals through a plurality of transformation. The gel also has high transdermal efficiency, and full dermal permeabilities are not different between species and different parts. The gel avoids the deficiencies of injections and oral liquid medicines, is safe owing to the external use, and has no toxicity and side effects. The gel has simple components, low cost, requires no special devices and production conditions, and is available for large-scale industrialized production.

The invention discloses a bubbling fluidized bed body structure capable of simultaneously realizing winnowing and drying. The bubbling fluidized bed body structure capable of simultaneously realizing winnowing and drying comprises a shell body and an air distribution plate, wherein the shell body and the air distribution plate enclose to form a fluidized bed holding chamber; the groove-shaped air distribution plate tilts from the feed end of a bed body to the discharge end of the bed body, the air distribution plate mainly consists of a bottom air distribution plate in the middle and side air distribution plates on the two sides, bottom ventilating holes and side ventilating holes which are communicated with sectional air chambers are respectively formed on the bottom air distribution plate and the side air distribution plates, and the bottom air distribution plate is formed by tandem connection of more than three sections of air distribution component plates; a front end air distribution component plate closest to the feed end of the bed body is tooth-shaped or the like, and air nozzles towards the discharge end are arranged at the bottom ventilating holes; air caps with hole mouths which are uniformly distributed are arranged on other air distribution component plates, and discharge outlets are formed in the tail parts of other air distribution component plates; side air nozzles towards a position right above the bottom air distribution plate are arranged at the side ventilating holes of the side air distribution plates. The bubbling fluidized bed body structure capable of simultaneously realizing winnowing and drying has the advantages that the structure is simple and the effects of drying wet particle materials to proper moisture and winnowing the materials for sorting and separation according to particle size can be simultaneously realized.

The invention provides a naproxen colon-specific drug-release micro pill and a preparation method thereof, and belongs to the technical field of medicines. The micro pill comprises a pill core, a swelling layer, a controlled release layer and an enteric coated layer. The naproxen colon-specific drug-release micro pill prepared by a fluidized bed coating method can ensure that drugs do not release in the stomach and small intestine to achieve colon-specific rdug-release effects so as to reduce the irritation of naproxen on gastrointestinal mucosa, the process is simple and feasible, the production efficiency is high, the cost is low, and the industrialized production is easy to realize.

The invention discloses a soluble origanum oil premix and a preparation method thereof and belongs to the field of veterinary preparations. The soluble origanum oil premix is composed of origanum oil, solvent and carrier. The soluble origanum oil premix has the advantages of simple preparation method, high medicine content uniformity and water solubility.

The invention discloses a synthesizing method of N, N'-dicyclohexyl thiourea, which comprises the following steps: adopting water as reacting solvent and 1-5% PEG-400 as catalyst; reacting thiourea and diisopropylamine with molar rate at 0.4-0.6: 1 heat by microwave with frequency at 2450MHz and powder at 400-800W for 0.4-3min; filtering; washing; separating to obtain the product.