Chinese herbal compound film for treating dermatomycosis and preparation method thereof

Abstract

The invention discloses a Chinese herbal compound film for treating dermatomycosis and a preparation method thereof. The compound film comprises the following raw materials: turmeric extract, blackberry lily extract and gardenia extract. The turmeric extract, blackberry lily extract and gardenia extract are added into a film forming solution prepared from auxiliary materials such as polyvinyl alcohol, glycerol and the like in a ratio of (2-8):(1-5):(1-3), and then a suitable solubilizer and a transdermal enhancer are added to prepare the Chinese herbal compound film. The prepared film has the advantages of high viscosity, high medicine penetrating power, convenience in use and the like; the film has an effect of resisting microsporum canis, alpha fungus, microsporum gypseum and candida albicans, and can be used for treating dermatomycosis caused by the fungus above.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine compound coating agent for treating dermatophytosis and a preparation method thereof, in particular to a traditional Chinese medicine compound coating agent for preventing and treating dermatophytosis, a preparation method and application thereof. Background technique

[0002] Dermatophytes are a group of fungi that can invade the skin, hair, and nails of humans and animals. Their prominent biological characteristics are keratinophilia and cause superficial skin infections. Among the dermatophytes that have been studied extensively and deeply are Microsporum canis, Trichophyton mentagrophytes, Microsporum gypsumoid and Candida albicans. It will secrete a variety of proteases in the process of invading the host, such as keratinase, elastase and collagenase. The enzyme with keratin hydrolysis activity is one of the most in-depth studies and the most important one among the virulence factors of derm...

Examples

Embodiment 1

[0034] Extract preparation:

[0035] Preparation of turmeric extract: take turmeric root powder, heat it to 70-80°C in 50-80% ethanol in an amount of 5-10 times, keep warm and soak for 1-3 times, and extract for 1-2 hours each time, filter and combine The filtrate was concentrated and dried under reduced pressure to obtain the turmeric extract;

[0036] Preparation of Shegan extract: Take Shegan root powder, add 5-10 times the amount of 50-80% ethanol to reflux extraction for 1-3 times, each time for 1-2 hours, combine alcohol extracts, concentrate and dry to obtain Shegan extract.

[0037] Preparation of gardenia extract: take gardenia fruit powder, reflux extract with 3-8 times the amount of 50-80% ethanol for 1-3 times, each time for 0.5-2 hours, combine the alcohol extracts, concentrate and dry to obtain gardenia extract things.

[0038] Preparation of Chinese medicine compound coating agent:

[0039] Take 6g of polyvinyl alcohol and 50g of distilled water, heat and dis...

Embodiment 2

[0041] The preparation of extract is with embodiment 1;

[0042] Preparation of Chinese medicine compound coating agent:

[0043] Take 8g of polyvinyl alcohol and 50g of distilled water, heat and dissolve on a water bath, then add 2g of glycerin, shake well, and adjust its volume to 100ml with distilled water to obtain a film-forming solution. Mix turmeric extract, shegan extract, and gardenia extract in a mass ratio of 3:2:1, then weigh 6.75g and add it to the film-forming solution, stir to dissolve, then add Tween-80 5g, Stir while adding, and finally add 10g of 1,2-propanediol, 8g of borneol and 15g of azone, and stir evenly to obtain the finished Chinese medicine compound coating agent; . After testing, the properties of the film coating agent are milky white, translucent viscous liquid, and the pH, loading capacity and microbial limit are all qualified.

Embodiment 3

[0045] The preparation of extract is with embodiment 1;

[0046] Preparation of Chinese medicine compound coating agent:

[0047] Take 10g of polyvinyl alcohol and 50g of distilled water, heat and dissolve on a water bath, then add 2g of glycerin, shake well, and adjust its volume to 100ml with distilled water to obtain a film-forming solution. Mix turmeric extract, shegan extract, and gardenia extract in a mass ratio of 4:3:2, then weigh 20.25g and add it to the film-forming solution, stir to dissolve, then add Tween-80 5g, Stir while adding, and finally add 10g of 1,2-propanediol, 8g of borneol and 5g of azone, and stir evenly to obtain the finished Chinese medicine compound coating agent; . After testing, the properties of the film coating agent are milky white, translucent viscous liquid, and the pH, loading capacity and microbial limit are all qualified.

technical field

[0001] The invention relates to a traditional Chinese medicine compound coating agent for treating dermatophytosis and a preparation method thereof, in particular to a traditional Chinese medicine compound coating agent for preventing and treating dermatophytosis, a preparation method and application thereof. Background technique

[0002] Dermatophytes are a group of fungi that can invade the skin, hair, and nails of humans and animals. Their prominent biological characteristics are keratinophilia and cause superficial skin infections. Among the dermatophytes that have been studied extensively and deeply are Microsporum canis, Trichophyton mentagrophytes, Microsporum gypsumoid and Candida albicans. It will secrete a variety of proteases in the process of invading the host, such as keratinase, elastase and collagenase. The enzyme with keratin hydrolysis activity is one of the most in-depth studies and the most important one among the virulence factors of derm...

Examples

Embodiment 1

[0034] Extract preparation:

[0035] Preparation of turmeric extract: take turmeric root powder, heat it to 70-80°C in 50-80% ethanol in an amount of 5-10 times, keep warm and soak for 1-3 times, and extract for 1-2 hours each time, filter and combine The filtrate was concentrated and dried under reduced pressure to obtain the turmeric extract;

[0036] Preparation of Shegan extract: Take Shegan root powder, add 5-10 times the amount of 50-80% ethanol to reflux extraction for 1-3 times, each time for 1-2 hours, combine alcohol extracts, concentrate and dry to obtain Shegan extract.

[0037] Preparation of gardenia extract: take gardenia fruit powder, reflux extract with 3-8 times the amount of 50-80% ethanol for 1-3 times, each time for 0.5-2 hours, combine the alcohol extracts, concentrate and dry to obtain gardenia extract things.

[0038] Preparation of Chinese medicine compound coating agent:

[0039] Take 6g of polyvinyl alcohol and 50g of distilled water, heat and dis...

Embodiment 2

[0041] The preparation of extract is with embodiment 1;

[0042] Preparation of Chinese medicine compound coating agent:

[0043] Take 8g of polyvinyl alcohol and 50g of distilled water, heat and dissolve on a water bath, then add 2g of glycerin, shake well, and adjust its volume to 100ml with distilled water to obtain a film-forming solution. Mix turmeric extract, shegan extract, and gardenia extract in a mass ratio of 3:2:1, then weigh 6.75g and add it to the film-forming solution, stir to dissolve, then add Tween-80 5g, Stir while adding, and finally add 10g of 1,2-propanediol, 8g of borneol and 15g of azone, and stir evenly to obtain the finished Chinese medicine compound coating agent; . After testing, the properties of the film coating agent are milky white, translucent viscous liquid, and the pH, loading capacity and microbial limit are all qualified.

Embodiment 3

[0045] The preparation of extract is with embodiment 1;

[0046] Preparation of Chinese medicine compound coating agent:

[0047] Take 10g of polyvinyl alcohol and 50g of distilled water, heat and dissolve on a water bath, then add 2g of glycerin, shake well, and adjust its volume to 100ml with distilled water to obtain a film-forming solution. Mix turmeric extract, shegan extract, and gardenia extract in a mass ratio of 4:3:2, then weigh 20.25g and add it to the film-forming solution, stir to dissolve, then add Tween-80 5g, Stir while adding, and finally add 10g of 1,2-propanediol, 8g of borneol and 5g of azone, and stir evenly to obtain the finished Chinese medicine compound coating agent; . After testing, the properties of the film coating agent are milky white, translucent viscous liquid, and the pH, loading capacity and microbial limit are all qualified.