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Preparation method of chitosan

A chitosan, purpose technology, applied in the field of preparation of chitosan, can solve the problems of low deacetylation degree of chitosan, accelerated deacetylation rate, long processing time, etc., to achieve easy industrialized large-scale production, Simple process operation and high degree of deacetylation

Active Publication Date: 2013-07-17
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shortcoming of these methods is: (1) kind of method prepares chitosan, required processing time is long, consumes a large amount of alkali, the production cost is high, and the degree of deacetylation of gained chitosan is lower; method, energy consumption is high, and the viscosity of chitosan product is low; Although the third method can accelerate the deacetylation rate and shorten the reaction time, its disadvantage is that the microwave heating speed is very fast, and local overheating easily occurs, and it is easy to cause microwave leakage
At present, most domestic production units still use the traditional lye heating method for deacetylation reaction, the degree of deacetylation is generally around 80%, and this method takes a long time to react and consumes high energy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The chitin raw material was crushed into 20-mesh particles by a pulverizer; 35% NaOH solution was added according to the ratio of 1g: 2ml, and ultrasonic treatment was performed at 60°C for 0.5h; Heating method: React at 85°C for 1 hour; after the reaction, take it out, cool it to room temperature, filter it, wash it repeatedly with water until it becomes neutral, and dry it to obtain the chitosan product. After measurement, the degree of deacetylation was 92.35%, and the viscosity was 1808mPa·s.

Embodiment 2

[0016] The chitin raw material was crushed into 60-mesh particles by a pulverizer; 45% NaOH solution was added according to the ratio of 1g:5ml, and ultrasonic treatment was performed at 65°C for 3 hours; Reaction at 95°C for 3 hours; after the reaction, take it out, cool it to room temperature, filter it, wash it repeatedly with water until it becomes neutral, and dry it to obtain the chitosan product. It was determined that the degree of deacetylation was 92.84%, and the viscosity was 1876mPa·s.

Embodiment 3

[0018] The chitin raw material was pulverized into 40-mesh particles by a pulverizer; 40% NaOH solution was added according to the ratio of 1g: 3ml, and ultrasonic treatment was performed at 63°C for 1.5h; Heating method: react at 90°C for 2 hours; after the reaction is completed, take it out and cool it to room temperature, filter it, wash it repeatedly with water until it becomes neutral, and dry it to obtain the chitosan product. It was measured that the degree of deacetylation was 92.56%, and the viscosity was 1902 mPa·s.

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Abstract

The invention discloses a preparation method of chitosan. The preparation method comprises the following steps of: chitin raw material crushing, ultrasonic pretreatment and eacetylation carried out by using an alkaline solution heating method. Compared with the chitosan prepared by the prior art, the chitosan prepared by using the process disclosed by the invention is high in deacetylation degree, low in alkaline solution concentration, low in equipment corrosivity, short in reaction time, reduced in production cost, environment-friendly, energy-saving, stable in process and suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a preparation method of chitosan, in particular to a method for preparing chitosan through raw material crushing, secondary ultrasonic pretreatment and lye deacetylation of chitin. Background technique [0002] Chitin, also known as chitin, is a natural linear polysaccharide with the chemical name β-(1→4)-2-acetate amino-2-deoxy-D-glucose, widely found in shrimp, crab, insects, etc. In the outer shell of cellulose and in the cell walls of mushrooms, fungi, bacteria, etc., it is the second largest renewable resource on the earth, and its content is second only to cellulose. Due to the hydrogen bond interaction within and between molecules of chitin, an ordered molecular structure is formed, and its solubility is very poor. It is insoluble in dilute acids, dilute alkalis and organic solvents, which greatly limits its application. Chitosan (Chitosan) is one of the most important derivatives of chitin. It is converted from the ace...

Claims

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Application Information

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IPC IPC(8): C08B37/08
Inventor 黄永亮郁正刚
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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