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Process for preparing 1-(4-chlorphenyl)-4,4-dimethyl-3-pentanone

A preparation process and chlorophenyl technology, applied in the chemical industry, can solve the problems of low product content, high production cost, long reaction time, etc., and achieve the effects of reducing side reactions, increasing content, and reducing production costs

Active Publication Date: 2013-08-14
内蒙古沙洲化学科技有限公司
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Problems solved by technology

However, the existing process has the problems of long reaction time, low product content and high production cost, so the existing process needs to be improved

Method used

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Embodiment Construction

[0014] The present invention will be specifically introduced below in conjunction with specific embodiments.

[0015] The preparation process of 1-(4-chlorophenyl)-4,4-dimethyl-3-pentanone (hereinafter referred to as pentanone):

[0016] 1. Condensation of p-chlorobenzaldehyde and pinacol at 70°C, using methanol as solvent and sodium hydroxide as catalyst, the content of sodium hydroxide in each 100L reaction solution is 2-5g to obtain the intermediate product ketene;

[0017] 2. Dissolve the ketene obtained in step 1 in methanol, add sodium hydroxide as a catalyst, and pass hydrogen at 50-80°C for hydrogenation. The content of sodium hydroxide per 100L of the reaction solution is 2-5g. The partial pressure of hydrogen is 2.5-3.0MPa to obtain the final product pentanone;

[0018] 3. After the preparation of pentanone is completed, the reaction system is settled, and the upper layer solution is collected. The upper layer solution contains the catalyst sodium hydroxide for recycling.

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Abstract

The invention discloses a process for preparing 1-(4-chlorphenyl)-4,4-dimethyl-3-pentanone. The process is characterized by comprising the following steps: 1, preparing ketene, namely condensing p-chlorobenzaldehyde and pinacolin under the temperature of 70 DEG C by taking methanol as a solvent and taking sodium hydroxide as a catalyst to prepare the ketene; and 2, preparing pentanone, namely dissolving the ketene in methanol, adding the catalyst of sodium hydroxide, introducing hydrogen for hydrogenation under the temperature of 50-80 DEG C to prepare pentanone. The process has the beneficial effects that sodium hydroxide serves as the catalyst and methanol serves as the solvent in the ketene preparation process, so that the side reaction is effectively reduced, the content of the ketene is improved, and the reaction time is greatly shortened; and moreover, sodium hydroxide serves as the catalyst in the pentanone preparation process, so that the problems that the precious metal serves as the hydrogenation catalyst and the hydrogenation is incomplete in the prior art are effectively solved, the production cost is greatly reduced, and the hydrogenation conversion rate is over 99.2 percent.

Description

Technical field [0001] The invention relates to a preparation process of 1-(4-chlorophenyl)-4,4-dimethyl-3-pentanone, and belongs to the technical field of chemical industry. Background technique [0002] 1-(4-Chlorophenyl)-4,4-dimethyl-3-pentanone is one of the important intermediates for the production of the new fungicide tebuconazole. The existing process for preparing 1-(4-chlorophenyl)-4,4-dimethyl-3-pentanone mainly adopts the condensation of p-chlorobenzaldehyde and pinacol, and then hydrogenation. However, the existing process has the problems of long reaction time, low product content, and high production cost. Therefore, the existing process needs to be improved. Summary of the invention [0003] In order to solve the deficiencies of the prior art, the purpose of the present invention is to provide a 1-(4-chlorophenyl)-4,4-dimethyl group with less side reactions, high product content, short reaction time, and effective production cost reduction. The preparation proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/235C07C49/233C07C45/74C07C45/62
CPCY02P20/584
Inventor 葛鹏圣曹爱春郁培华钱志强赵松雪
Owner 内蒙古沙洲化学科技有限公司
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