Anthranilamide compound as well as preparation method and application thereof

A technology of anthranilamide and anthranilamide, which is applied in the field of anthranilamide compounds and their preparation, can solve problems such as poor effect, and achieve the effects of low cost, simple preparation method and remarkable effect

Active Publication Date: 2013-08-28
江苏省农用激素工程技术研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its single agent is not effective in controlli

Method used

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  • Anthranilamide compound as well as preparation method and application thereof
  • Anthranilamide compound as well as preparation method and application thereof
  • Anthranilamide compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0030] The chemical name of the anthranilamide compound in this embodiment is: 3-bromo-1-(3-chloro-2-pyridyl)-N-[4-thioformamide-2-methyl-6-( Methylcarbamoyl)-phenyl]-1H-pyrazole-5-carboxamide, its structural formula is as follows:

[0031]

[0032] The preparation method of this anthranilamide compound is as follows:

[0033] Add 3.0g of 70wt% NaSH (0.0375mol), 1.9g of magnesium chloride (0.02mol) and 50mL of ethylene glycol dimethyl ether into a 250mL four-neck flask, stir to dissolve completely, and then add 9.5g of bromcyanogen Add tebendamide (0.02mol) into the reaction system, raise the temperature to 25°C under stirring, and keep it warm for 10-11 hours.

[0034] After the reaction was completed, ethylene glycol dimethyl ether was distilled off under vacuum first, then 100 mL of water was added, and the pH was adjusted to 6-7 with hydrochloric acid, then stirred at below 10°C for 1 h, and filtered to obtain 9.8 g of a khaki-yellow crude product. The yield was 86.7%...

Embodiment 2～ Embodiment 4）

[0038] The compound of each example is the same as that of Example 1.

[0039] The preparation method of each embodiment is basically the same as that of Example 1, and the differences are shown in Table 1.

[0040] Table 1

[0041]

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Abstract

The invention discloses an anthranilamide compound as well as a preparation method and an application thereof. The compound has the chemical name as follows: 3-bromine-1-(3-Cl-2-pyridyl)-N-[4-methanethioamido-2-methyl-6-(methylaminoformyl)-phenyl-1H-pyrazol-5-methanamide, and is obtained through enabling bromine cyanide insect amide and a vulcanizing agent to react in the existence of a polar organic solvent and a catalyst at the temperature of 0-100 DEG C. The compound disclosed by the invention can be used for independently preparing an insecticide or preparing a mixed insecticide together with abamectin insecticides, neonicotinoid insecticides or pyrethroid insecticides, and the independently prepared insecticide is used for preventing and controlling Lepidoptera pests, dipteral pests or hemiptera pests.

Description

technical field [0001] The invention belongs to the field of pesticides and insecticides, and in particular relates to an anthranilamide compound capable of preparing insecticides, a preparation method and application thereof. Background technique [0002] The control of pests is one of the core fields of pesticide scientific research, which involves the increase of food production and harvest that human beings depend on for survival. [0003] With the advancement of science, the field of pesticides has continuously developed new high-efficiency, low-toxicity insecticides to replace highly toxic insecticides, such as organophosphorus insecticides, carbamate insecticides and so on. [0004] As a representative of high-efficiency and low-toxic insecticides, neonicotinoid insecticides have a history of more than 20 years, and many of them have developed resistance. [0005] Anthranilamide insecticides are a relatively new class of high-efficiency and low-toxicity insecticides....

Claims

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Application Information

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IPC IPC(8): C07D401/04A01N43/56A01P7/04
Inventor 孔繁蕾吴桂秀马英高
Owner 江苏省农用激素工程技术研究中心有限公司
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