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Isothiazole-o-pyrimidone compound and application thereof

A compound and pyrimidinone technology, applied in the field of isothiazolopyrimidone compounds, can solve problems such as structural isothiazolopyrimidone compounds that have not been reported

Active Publication Date: 2015-03-18
SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the prior art, the structure of the isothiazolopyrimidinone compound shown in the general formula I of the present invention has not been reported

Method used

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  • Isothiazole-o-pyrimidone compound and application thereof
  • Isothiazole-o-pyrimidone compound and application thereof
  • Isothiazole-o-pyrimidone compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Example 1: Preparation of Compound 160

[0122]

[0123] 1), the preparation of intermediate 4-amino-3-phenyl-5-isothiazole ethyl formate (II-1)

[0124] (1) Preparation of benzoyl nitrile oxime sodium salt

[0125] Weigh 8.15 grams (0.20 moles) of sodium hydroxide, 23.41 grams (0.20 moles) of phenylacetonitrile and put them into a 1000 milliliter three-necked flask equipped with mechanical stirring, a thermometer and a tail gas absorption device, add 150 milliliters of dehydrated alcohol, and cool down to 10-20℃. At this temperature, a solution of 28.11 g (0.24 mol) of isoamyl nitrite in 50 ml of absolute ethanol was slowly added dropwise thereto. After the dropwise addition, the ice bath was removed, and the reaction was continued at room temperature for 2.5 hours. After the completion of the reaction monitored by TLC, 200 ml of ether was added to the reaction solution, stirred for 30 minutes, filtered, and the filter cake was washed with ether, air-dried and va...

Embodiment 2

[0148] Example 2: 30% Compound 7 WP

[0149]

[0150] Compound 7 and other components are thoroughly mixed and crushed by a superfine pulverizer to obtain a 30% wettable powder product.

Embodiment 3

[0151] Example 3: 30% Compound 48 WP

[0152]

[0153] Compound 48 and other components are thoroughly mixed, and after being pulverized by an ultrafine pulverizer, a 30% wettable powder product is obtained.

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Abstract

The invention discloses an isothiazole-o-pyrimidone compound. The compound has the structure shown in the general formula I, wherein each substituent group is defined in the specification. The compound with the general formula I has high activity on multiple pathogenic bacteria in the agricultural field and particularly has a good effect of preventing and treating rice blast, cucumber downy mildew, cucumber gray mold and puccinia polysra under low dose; moreover, the compound also has high insecticidal activity. Therefore, the invention comprises application of the compound which is shown in the general formula I and serves as a fungicide and a pesticide in the fields of agriculture and the like.

Description

technical field [0001] The invention belongs to the field of agricultural sterilization and insecticide. Specifically relate to a kind of isothiazolopyrimidone compound and its use. Background technique [0002] Since germs and pests will develop resistance to fungicides and insecticides after being used for a period of time, new and improved compounds and compositions with bactericidal and insecticidal activities need to be continuously developed. At the same time, with the increasing demand for agricultural and livestock products and the increasing emphasis on environmental protection, new sterilization and insecticides with lower cost and environmental friendliness have always been required. [0003] Patent US4539328A relates to compounds of the following general formula as nematicides: [0004] [0005] Wherein: A is selected from hydroxyl, alkoxy, benzyloxy, NHR; R is selected from hydrogen, alkyl, CH 2 CH 3 OH, CH 2 CH 2 OCOCH 3 ; Z is selected from hydrogen,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D513/04A01N43/90A01P3/00A01P7/04
Inventor 康卓张静孙芹关爱莹梁博李淼王军锋宋玉泉刘长令
Owner SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD
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