A kind of concentration method of erythromycin fermented liquid
A technology of fermented liquid and erythromycin, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as short life, high production cost, and rapid decline in flux of nanofiltration membranes, and achieve Effects of prolonging life, improving quality, and reducing production cost
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Embodiment 1
[0018] The concentration method of embodiment 1 erythromycin fermented liquid of the present invention
[0019] (1) Take the erythromycin fermentation broth, adjust the pH to 7.0-8.5, and filter it with a ceramic membrane with a pore size of 0.1 μm to obtain the filtrate;
[0020] (2) Use strong basic acrylic acid anion exchange resin to decolorize and remove impurities from the filtrate obtained in step (1), the column pressure is 0.2MPa, and the flow rate is 32m 3 / h, the pH of the upper column solution is 7.5 to obtain a decolorizing solution; then filter with a filter bag with a precision of 10-50 μm to obtain a filtrate;
[0021] (3) Take the filtrate from step (2) for nanofiltration, using a nanofiltration membrane with a molecular weight of 200.
Embodiment 2
[0022] The parameter screening of the concentration method of embodiment 2 erythromycin fermented liquid of the present invention
[0023] 1. Experimental method
[0024] The remaining steps are the same as in Example 1, and the parameters of resin removal in step (2) are adjusted according to Table 1.
[0025] 2. Experimental results
[0026] The experimental results are shown in Table 1:
[0027] The impact of different resin impurity removal parameters on the decolorization solution in table 1
[0028]
[0029]
[0030] As can be seen from Table 1:
[0031] When decoloring, the column pressure is 0.05-0.5MPa, and the pH of the upper column solution (feed pH) is 7.0-8.0, the light transmittance of the decolorizing solution is over 67%, and the cleaning flux of the membrane can recover over 78%. The lifespan is more than 12 months;
[0032] When the column pressure is 0.05-0.3MPa, and the pH of the upper column solution (feed pH) is 7.0-8.0, the light transmittance...
Embodiment 3
[0035] Embodiment 3 Parameter screening of the erythromycin fermented liquid concentration method of the present invention
[0036] 1. Experimental method
[0037] The remaining steps are the same as in Example 1, and the precision of the nanofiltration membrane in step (3) is adjusted according to Table 2.
[0038] 2. Experimental results
[0039] The experimental results are shown in Table 2:
[0040] Table 2 Effect of different precision nanofiltration membranes on decolorization solution
[0041]
[0042] As can be seen from Table 2, the yield of the 600 molecular weight nanofiltration membrane is about 6.4% lower than that of the 200 molecular weight nanofiltration membrane in actual use, indicating that the 200 molecular weight nanofiltration membrane is more suitable for the concentration of erythromycin.
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Abstract
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