Portable paper chip capable of visually detecting chlorine ion content in sweat

A chloride ion content, paper chip technology, applied in the field of hereditary diseases), can solve the problems of large sampling volume, limited application objects and occasions, volume and weight affecting portable effect, etc., to improve accuracy, simplify operation steps, and facilitate Monitoring the effect

Active Publication Date: 2013-10-02
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The device is mainly composed of an electronic multimeter and a chloride ion selective electrode, which not only has a large sampling volume (that is, requires a lot of sweat), which limits the application objects and occasions, but also its volume and weight seriously affect the portable effect.

Method used

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  • Portable paper chip capable of visually detecting chlorine ion content in sweat
  • Portable paper chip capable of visually detecting chlorine ion content in sweat
  • Portable paper chip capable of visually detecting chlorine ion content in sweat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Step 1: Make the corresponding paper structure according to the design size, see figure 1 ; 6 is a circular hole, its diameter is 1-3mm; 2 is anion exchange paper, Whatman DE81 or Pall Mustang, its diameter is slightly larger than 6, 2-4mm, 3 is pH test paper or modified with pH sensitive quantum dots (fluorescent dye ) paper, its diameter is slightly larger than 2, 3-5mm; the diameter of the circular end of 4 is slightly larger than 6, 2-4mm, the length of 4 is 2cm; the length of 1 is 3-5cm, and the width is 1- 3cm; 7 is made by an inkjet printer; 5 is 3M Tegaderm adhesive paper, its size is slightly larger than 1, with a length of 4-6cm and a width of 2-4cm;

[0042] Step 2: Assemble 1-5 according to the design to get a paper chip. 5 is sticky, through the tight combination with 1, the position of other components is fixed; the cross-section of the paper chip after assembly is shown in figure 2 ;

[0043] The third step: preparing a gradient concentration solutio...

Embodiment 2

[0048] Step 1: Make the corresponding paper structure according to the design size, see figure 1 Make the corresponding paper structure according to the design size, and assemble the corresponding paper structure; the diameter of 6 is 1-3mm, the diameter of 2 is slightly larger than 6, 2-4mm, and the diameter of 3 is slightly larger than 2, 3-5mm; The diameter of the circular end of 4 is slightly larger than that of 6, which is 2-4mm, and the length of 4 is 2cm; the length of 1 is 3-5cm, and the width is 1-3cm; 2-4cm;

[0049] Step 2: Assemble 1-5 according to the design to get a paper chip. 5 is sticky, through the tight combination with 1, the position of other components is fixed; the cross-section of the paper chip after assembly is shown in figure 2 ;

[0050] The third step: prepare a gradient concentration solution of sodium chloride, 0mM-100mM;

[0051] Step 4: Detect sodium chloride solution to establish a standard curve; put the paper chip on 9 and wait for the...

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Abstract

The invention relates to a portable paper chip capable of visually detecting the chlorine ion content in sweat. The portable paper chip is provided with paper which can generate color or fluorescence changes according to the pH and a double-layer structure of anion exchange paper which is arranged on the lower surface of the paper. The invention also relates to a method for visually detecting the chlorine ion content in sweat by using the paper chip and applications of the paper chip for physiological status monitoring and diagnosis of cystic fibrosis diseases.

Description

technical field [0001] The present invention relates to a small paper-based device for the in situ, visual detection of chloride ions in sweat and its use for physiological condition monitoring and initial screening for cystic fibrosis, an inherited disease. Background technique [0002] Visual and portable body fluid detection equipment is one of the important directions for the future development of personalized medicine. Portable devices can allow clinical testing at home and in public places, and visualized testing results can quickly reflect physiological and pathological information in body fluids, greatly improving the efficiency of medical diagnosis. Sweat is a major form of body fluid that includes various compounds such as metal salts, sugars, and organic acids. Its main features are 1) It is directly excreted from the body, not an invasive collection method, and has a very low risk of infection; 2) Exercise, heat sources, and compounds can all stimulate the disch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/80G01N21/64
CPCA61B5/4266G01N31/221G01N33/487G01N33/525G01N33/526G01N33/84
Inventor 郑直慕轩
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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