Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof

An autoimmune and compositional technology, applied in the field of liver disease treatment, can solve problems affecting the advantages of traditional Chinese medicine, achieve clear pharmacological mechanisms, improve efficacy, and regulate immune function

Inactive Publication Date: 2015-05-13
毛德文 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is still a lack of traditional Chinese medicine preparations for the treatment of autoimmune liver diseases, which seriously affects the advantages of traditional Chinese medicine.

Method used

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  • Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof
  • Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Formula 1: 1000 grams of astragalus, 750 grams of cooked rhubarb, 750 grams of Ligustrum lucidum, 750 grams of turmeric, 750 grams of Gentiana, 600 grams of Caulis Spatholobus, 600 grams of Qingfengteng, 500 grams of madder, 500 grams of weeping grass, licorice 400 grams.

[0037] Preparation method:

[0038] (1) Weigh each raw medicinal material according to the formula quantity;

[0039] (2) Add water to decoct the raw medicinal materials for 2 times, each time for 2 hours, the amount of water added each time is 12 times the total amount of raw medicinal materials, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.05 (70°C) clear ointment, let cool;

[0040] (3) Add ethanol to the clear paste prepared in step (2) so that the ethanol content is 60%, stir well, let it stand overnight, filter off the precipitate, recycle the ethanol from the filtrate and concentrate it to a relative density of 1.30 (80 ℃) thick paste;

[0041] (4) A...

Embodiment 2

[0043] Formula 2: 1500 grams of astragalus, 500 grams of cooked rhubarb, 1500 grams of Ligustrum lucidum, 750 grams of turmeric, 500 grams of Gentiana, 1000 grams of Caulis Spatholobus, 750 grams of Qingfengteng, 500 grams of madder, 500 grams of weeping grass, licorice 500 g.

[0044] The preparation method is basically the same as that in Example 1. The relative density of the clear ointment is 1.07 (70°C), and the relative density of the thick ointment is 1.30 (80°C); 1000g of granules are prepared and divided into 10g (equivalent to 80g of crude drug) per bag.

Embodiment 3

[0046] Formula 3: 1000 grams of astragalus, 1000 grams of cooked rhubarb, 750 grams of Ligustrum lucidum, 1500 grams of turmeric, 750 grams of Gentiana, 1500 grams of Caulis Spatholobus, 1000 grams of Qingfengteng, 1500 grams of madder, 500 grams of weeping grass, licorice 400 grams.

[0047] The preparation method is basically the same as that in Example 1. The relative density of the clear paste is 1.10 (70°C), and the relative density of the thick paste is 1.35 (80°C); 1000g of granules are prepared, and divided into 10g (equivalent to 99g of crude drug) per bag.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating an autoimmune liver disease, and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 10-30 parts of cooked rhubarb, 10-30 parts of glossy privet fruit, 10-30 parts of radix curcumae, 10-30 parts of large-leaved gentian, 10-30 parts of caulis spatholobi, 10-30 parts of caulis sinomenii, 10-30 parts of radix rubiae, 10-30 parts of sedum sarmentosum and 5-15 parts of liquorice. The traditional Chinese medicine has the effects of strengthening body resistance, detoxifying, dispersing stagnated liver qi for promoting bile flow, promoting blood circulation to remove blood stasis, expelling wind and removing dampness; the main treatment range comprises autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and overlap syndrome of any two in the three diseases; and the traditional Chinese medicine composition has the treatment effects of restoring immune balance, inhibiting liver inflammation, protecting liver function, resisting hepatic fibrosis, improving clinical symptoms, improving survival quality and the like, and has high safety.

Description

technical field [0001] The invention belongs to the technical field of liver disease treatment, and in particular relates to a traditional Chinese medicine composition for treating autoimmune liver disease and a preparation method thereof. Background technique [0002] Autoimmune liver diseases (AILD) are a group of autoimmune-mediated hepatobiliary system damage diseases, mainly including autoimmune hepatitis (autoimmune hepatitis, AIH), primary biliary cirrhosis (primary biliary cirrhosis) , PBC), primary sclerosing cholangitis (Primary sclerosing cholangitis, PSC), and overlap syndromes of any two of these three diseases. AILD is an idiopathic disease involving the liver parenchyma due to the immune dysfunction of the body. The onset is insidious, recurrent, protracted and difficult to heal, and eventually dies due to liver cirrhosis and liver failure. Due to environmental pollution, drugs, virus infection and other factors, the incidence of AILD in my country is increas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/16A61P37/02
Inventor 毛德文邱华
Owner 毛德文
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