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Micro-fluidic combined chemical reaction chip

A microfluidic chip and chemical reaction technology, applied in the field of microfluidics, can solve the problems of cumbersome operation, large consumption of reagents, and high requirements for operators, and achieve the effect of low sample consumption and small volume

Inactive Publication Date: 2013-11-13
苏州扬清芯片科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the above-mentioned combinatorial chemistry methods have been widely used and deeply researched, the prior art still has disadvantages such as large consumption of reagents, cumbersome operation, expensive equipment, high cost, and high requirements for operators.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 A microfluidic chip for pairwise reaction of three samples

[0018] In order to realize the combination chemical reaction of three samples in pairs, this embodiment proposes a microfluidic reaction chip, which is processed by PMMA. Such as figure 1 As shown, the microfluidic chip is composed of five layers of substrates, which are cover sheet a with fluid inlet and outlet holes, substrate b with mixed reaction unit, substrate c with through holes, and another mixed reaction unit with Substrate d, blank substrate e. Among them, different sample inlets are processed on the cover sheet a, which are used to introduce three different samples A, B, and C; Sheet c has a through-hole structure connecting the upper and lower substrates; substrate d has AC mixing intersection, mixing reaction and product outlets for use.

[0019] When using the above-mentioned microfluidic chip for combinatorial chemical synthesis, it is only necessary to pass samples A, B, and C int...

Embodiment 2

[0020] Example 2 A microfluidic chip for pairwise reaction of four samples

[0021] In order to realize chemical reactions in pairs of four samples, this embodiment proposes a microfluidic reaction chip processed by PMMA. Such as figure 2 As shown, the microfluidic chip is composed of a sample inlet, a sample converging channel, a mixing channel and a product outlet.

[0022] When using the above-mentioned microfluidic chip for combinatorial chemical synthesis, it is only necessary to pass samples A, B, C, and D into the sample inlet, and adjust a certain flow rate, then the sample solution flows through the intersection channel and the mixing channel in the microfluidic chip. Finally, a chemical reaction occurs, and six products of AB, AC, AD, BC, BD and CD can be collected continuously at the product outlet of the microfluidic chip.

Embodiment 3

[0023] Example 3 Schematic diagram of a microfluidic chip for any combination of three samples.

[0024] In order to realize the chemical reaction of any combination of the three samples, this embodiment proposes a microfluidic reaction chip, which is processed by polycarbonate. Such as image 3 As shown, the microfluidic chip is composed of a sample inlet, a sample converging channel, a mixing channel and a product outlet.

[0025] When using the above-mentioned microfluidic chip for combinatorial chemical synthesis, it is only necessary to pass samples A, B, and C into the sample inlet, and adjust a certain flow rate. After the sample solution flows through the converging channel and mixing channel in the microfluidic chip, When a chemical reaction occurs, four products AB, AC, BC and ABC can be collected continuously at the product outlet of the microfluidic chip.

[0026] Compared with the existing combinatorial chemical reaction methods, the combinatorial chemical react...

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Abstract

The invention discloses a micro-fluidic combined chemical reaction chip. The micro-fluidic combined chemical reaction chip is characterized by consisting of a sample solution inlet, a sample intersection channel, a mixing unit and a product outlet. A combined chemical reaction is a chemical reaction happened between any two or among more than two types of various samples. Compared with the existing chemical reaction method, the combined chemical reaction chip provided by the invention has the significant advantages of low sample consumption, high flux, small volume, automatic operation and the like, can be used for realizing quick and online combined chemical reactions, and can be hopefully applied to the fields of dug screening, enzyme screening, chemical synthesis, material preparation, chemical production and the like.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a microfluidic combined chemical reaction chip. Background technique [0002] Combinatorial chemistry (combina torialchemist) is a new discipline that has just emerged in the past ten years. After a short period of more than ten years, especially the development of the past six or seven years, combinatorial chemistry has penetrated into many fields of chemistry such as medicine, organic matter, materials, and analysis. With the improvement of automation level, combinatorial chemistry has become the most active in the chemical field. one of the fields. The emergence of combinatorial chemistry has greatly accelerated the speed of compound synthesis and screening. Some people have made such statistics: 1 chemist with a workload of 2 to 6 weeks using combinatorial chemistry methods requires 10 chemists to spend a year with traditional chemical methods To be done. The emergen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 叶嘉明
Owner 苏州扬清芯片科技有限公司
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