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Pharmaceutical composition containing ambroxol hydrochloride and fructose

A kind of technology of ambroxol hydrochloride and ambroxol hydrochloride injection, applied in the field of medicine

Inactive Publication Date: 2013-11-20
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical use, joint applications need to be purchased separately, and no combined packaging of ambroxol hydrochloride injection and fructose appears on the market or in medical institutions

Method used

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  • Pharmaceutical composition containing ambroxol hydrochloride and fructose
  • Pharmaceutical composition containing ambroxol hydrochloride and fructose
  • Pharmaceutical composition containing ambroxol hydrochloride and fructose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Ambroxol Hydrochloride Injection

[0037] prescription:

[0038]

[0039] making process:

[0040] (1) Add a total of 4800ml of water for injection into the container, and control the temperature at 70-80°C;

[0041] (2) Add 5.4g of aspartic acid and 23.1g of disodium hydrogen phosphate while stirring, and stir to dissolve completely;

[0042] (3) Weigh 3g of activated carbon for injection in the carbon mixing cabinet, add 150ml of water for injection to wet the activated carbon for injection, and set aside;

[0043] (4) Add the wetted activated carbon for injection and stir for 30 minutes;

[0044] (5) Decarbonize the solution by coarse filtration, and filter through a 0.45 μm cartridge filter;

[0045] (6) Then add 45g of ambroxol hydrochloride and stir to dissolve it completely;

[0046] (7) Add water for injection to 6000ml;

[0047] (8) The pH of the test liquid is 5.0 and has not been adjusted;

[0048] (9) Use a 0.22 μm micropo...

Embodiment 2

[0053] Example 2 Preparation of Ambroxol Hydrochloride for Injection

[0054] prescription:

[0055]

[0056] making process:

[0057] (1) Add a total of 4800ml of water for injection into the container, and control the temperature at 70-80°C;

[0058] (2) Add 5.4g of aspartic acid and 23.1g of disodium hydrogen phosphate while stirring, and stir to dissolve completely;

[0059] (3) Add 240g sorbitol and stir to dissolve completely;

[0060] (4) Weigh 3g of activated carbon for injection in the carbon mixing cabinet, add 150ml of water for injection to wet the activated carbon for injection, and set aside;

[0061] (5) Add the wetted activated carbon for injection and stir for 30 minutes;

[0062] (6) Decarbonize the solution by coarse filtration, and filter through a 0.45 μm cartridge filter;

[0063] (7) Then add 45g of ambroxol hydrochloride and stir to dissolve it completely;

[0064] (8) Add water for injection to 6000ml;

[0065] (9) The pH of the test liquid i...

Embodiment 3

[0071] Example 3 Preparation of Fructose Injection

[0072] prescription:

[0073]

[0074] making process:

[0075] (1) Concentrated formulation: Add 30L of water for injection into the concentrated formulation tank, add 10,000g of fructose, stir to dissolve, add 100g of wet medicinal charcoal, stir for 30 minutes, filter and decarbonize, filter into the diluted formulation tank, Rinse the concentrated preparation tank with water for injection several times, and filter into the thin preparation tank;

[0076] (2) Dilute formulation: add 90L of water for injection to the dilute formulation tank, adjust the pH value to 3.9 with 0.1mol / L hydrochloric acid solution, add 100g of wet medicinal charcoal, stir for 30 minutes, filter and decarbonize, Add water for injection to 100L;

[0077] (3) Fine filter with 0.22μm microporous membrane, fill, 250ml / bottle and 500ml / bottle, seal;

[0078] (4) Sterilization: Sterilize by autoclaving at 121°C for 15 minutes, quickly spray to...

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing an ambroxol hydrochloride injection preparation and a fructose injection liquid, and particularly relates to a combined application package comprising the ambroxol hydrochloride injection preparation and the fructose injection liquid. When the combined application package is in use, the ambroxol hydrochloride injection preparation and the fructose injection liquid are mixed for intravenous drip. The pharmaceutical composition has the effect for eliminating phlegm and excreting the phlegm and can supplement energy and body fluid for the human body.

Description

technical field [0001] The invention relates to a pharmaceutical composition comprising ambroxol hydrochloride and fructose, in particular to a combined application package composed of ambroxol hydrochloride injection and fructose injection, belonging to the technical field of medicine. Background technique [0002] Ambroxol hydrochloride has mucus elimination-promoting and secretion-dissolving properties. It can promote the elimination of viscous secretions in the respiratory tract and reduce the retention of mucus, because it can significantly promote expectoration and improve respiratory conditions. Application of ambroxol hydrochloride treatment, the patient's mucus secretion can return to normal conditions. Cough and sputum volume are usually significantly reduced, and the surface active substances of the respiratory mucosa thus exert their normal protective functions. The distribution of ambroxol hydrochloride from blood to tissues is fast and significant, and the lu...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K31/137A61K31/7004A61P11/10A61P11/12A61P7/08
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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