Pharmaceutical composition for treating alzheimer disease and preparation method as well as application thereof
A technology for Alzheimer's disease and composition, applied in the field of pharmaceutical composition for the treatment of Alzheimer's disease and its preparation and application, capable of solving uncertain clinical effects, no disclosed therapeutic effect, and no disclosed nervous acid and Panax notoginseng saponins etc.
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[0045] Panax notoginseng saponins are capsules prepared by the above preferred preparation method, and each capsule contains 60 mg of panax notoginseng total saponins;
[0046] The pharmaceutical composition of the present invention is prepared by adopting the above-mentioned preferred formula, that is, 40 parts by weight of nervous acid and 60 parts by weight of total notoginseng saponins are made into capsules, each capsule contains 40 mg of nervous acid and 60 mg of total notoginseng saponins; The preparation methods of the nervonic acid and the total saponins of Panax notoginseng are the same as above.
[0047] 1. Patient diagnostic criteria
[0048] 1.1 Diagnostic criteria: Included with reference to the "Diagnosis and Curative Effect Evaluation Criteria for Alzheimer's Disease" revised by the Geriatrics Society of the Chinese Association of Traditional Chinese Medicine and the Internal Medicine Society of the Chinese Association of Traditional Chinese Medicine in May 199...
Embodiment 1
[0073] Take 40 parts by weight of nervonic acid, 60 parts by weight of Panax notoginseng saponins, 200 parts by weight of lactose, take the above components and add an appropriate amount of starch to make a tablet; wherein the preparation method of nervonic acid is:
[0074] (1) Add 3 times of 95% ethanol to the garlic fruit oil, stir to form a uniform solution, add 25% sodium hydroxide solution of 4 / 3 times the quality of the garlic fruit oil to the solution, heat and stir until saponification Complete the reaction, filter, acidify the filtrate to pH 3-4 with hydrochloric acid, let it stand still, collect the solidified saponified product in the upper layer, wash with water until neutral, drip off the water, and obtain the crude nervonic acid;
[0075] (2) Take the crude product of nervonic acid and carry out the following crystallization operation:
[0076] Add 4 times the amount of a mixed solution of absolute ethanol and acetone with a volume ratio of 1:1 to the crude nerv...
Embodiment 2
[0081] Get 24 parts by weight of nervonic acid, 48 parts by weight of Panax notoginseng saponins, and make capsules; wherein the preparation method of nervonic acid is:
[0082] (1) Add 2 times the amount of 90% ethanol to the garlic fruit oil, stir into a uniform solution, add 20% potassium hydroxide solution of 2 times the amount of the garlic fruit oil quality in the solution, heat and stir until the saponification reaction is complete , filtered, the filtrate was acidified to pH 3-4 with sulfuric acid, left to stand, the upper layer was collected to solidify saponified matter, washed with water until neutral, and the water was dripped to obtain the crude nervonic acid;
[0083] (2) Take the crude product of nervonic acid and carry out the following crystallization operation:
[0084] Add 4.2 times the amount of a mixed solution of absolute ethanol and acetone with a volume ratio of 1:1 to the crude nervonic acid, heat to reflux at 60-70°C to dissolve, filter, collect the f...
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