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Non-medical increase or maintenance of body weight of a mammal

一种哺乳动物、非医疗的技术，应用在营养组合物领域，能够解决虚弱等问题，达到提高程度和频率、改善步态、降低持续时间的效果

Inactive Publication Date: 2013-11-20
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can even lead to weakness (as defined above)

Method used

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  • Non-medical increase or maintenance of body weight of a mammal
  • Non-medical increase or maintenance of body weight of a mammal
  • Non-medical increase or maintenance of body weight of a mammal

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0202]Specific embodiments: nutritional composition (per se)

[0203] As mentioned above, the present invention also relates to nutritional compositions comprising: (i) at least one ingredient selected from the group of uridine and uridine monophosphate; (ii) DHA and EPA (which can be bound, eg, as triglycerides); (iii) B vitamins; (iv) phospholipids; v) antioxidants; and (vi) choline. Preferred sources, specific compounds preferred for each group, concentrations, dosages and other product characteristics may generally be as described above. The nutritional composition according to the invention generally also comprises protein. In addition, digestible carbohydrates and fiber are usually present. Preferably, the nutritional composition comprises i-a) nucleoside uridine and i-b) nucleotide uridine monophosphate. Preferably i-a) uridine and i-b) uridine monophosphate are present in a weight ratio of 0.2:1 to 0.7:1. The presence of i-a) uridine and i-b) uridine monophosphate ...

Embodiment 1

[0235]APP / PS1 mice were provided with a diet rich in DHA and UMP (intake / day: DHA = 22.8 mg; UMP = 23.1 mg) or a control diet for 3 months. Both diets were isocaloric and differed only in DHA and UMP content. The amounts of fat, carbohydrates, and protein were the same between diets. During the 3-month dietary intervention, body weight was monitored, as was food intake.

[0236] Results After 3 months, mice fed the rich diet showed an average 17.5% increase in body weight compared to 14% in control mice. Food intake was slightly lower in the group fed the rich diet (mean 2.88 g / day) compared to control mice (mean 3.08 g / day).

[0237] Conclusion When fed the composition according to the invention (omega-3 polyunsaturated fatty acid DHA and nucleoside UMP), the mice showed an increase in body weight which was not attributable to an increase in calories in body weight.

Embodiment 2

[0239] Provide APP / PS1 mice with rich vitamin B (B6, B12 and folic acid; intake / day: B6=0.1mg; B12=0.11μg; folic acid=18.1μg), phospholipids (lecithin; intake / day : 12.4 mg) and antioxidants (vitamin C, vitamin E, selenium; intake / day: vitamin C = 4.8 mg; vitamin E = 4.5 mg; selenium = 3.2 μg) or provided a control diet for 3 months . The two diets were isocaloric and differed only in B vitamins, phospholipids and antioxidant content. The amounts of fat, carbohydrates, and protein were the same between diets. During the 3-month dietary intervention, body weight was monitored, as was food intake.

[0240] Results After 3 months, mice fed a diet rich in B vitamins + phospholipids + antioxidants showed an 18% increase in body weight compared to 14% in control mice. Food intake was slightly lower (average 2.86 g / day) in the vitamin B+phospholipids+antioxidant group compared to control mice (average 3.08 g / day).

[0241] Conclusions When fed the composition according to the inv...

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Abstract

Composition comprising at least two components, more preferably at least three components, more preferably at least four components, selected from the group of (i) a nucleoside equivalent, (ii) an omega-3 polyunsaturated fatty acid selected from the group of DHA, DPA and EPA, (iii) a vitamin B, (iv) a phospholipid, (v) an antioxidant and (vi) a choline, with the proviso that at least component (i) or (iii) is present, for use in the prevention or treatment of frailty in a mammal, wherein frailty is determined by compliance with at least 2 criterions, preferably 3 criterions, selected from the group of muscle weakness, excessive feelings of exhaustion or fatigue, abnormally low physical activity, slow or unsteady gait, weight loss, and neurological dysfunction.

Description

technical field [0001] The present invention relates to the combination of specific ingredients for gaining or maintaining body weight. The invention also relates to nutritional compositions which are particularly suitable for such applications. [0002] The invention also relates to specific related benefits that can be achieved in such persons, such as improvements in energy, increased activity levels during the day and related changes in lifestyle. Background technique [0003] Human body weight depends on the weight of different parts in the body, such as the weight of bones, muscles, organs, blood vessels, adipose tissue, etc. The contribution of each body part relative to total body weight varies throughout life. After maturation in the body has ceased, there will usually be a gradual and steady decline in muscle mass over time. This decline results in a decrease in lean body mass (LBM, which is body weight minus the mass of adipose tissue), despite the fact that ov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23J7/00A23L1/30A23L1/302A23L1/29A23L33/00A23L33/15
CPCA61K31/7056A61K31/675A61K31/20A61K31/519A61K31/7072A61K31/14A61K31/375A61K45/06A23V2002/00A61K31/202A61K31/683A23L1/3012A61K31/355A23L1/302A23L1/3008A61K31/661A61K31/4415A23L1/296A61K33/04A61K31/685A61K31/714A23L33/40A23L33/12A23L33/13A23L33/15C07H19/06C07H19/052A61P25/28A61K2300/00A23V2200/316A23V2200/322A23V2250/1882A23V2250/304A23V2250/704A23V2250/156A23V2250/1626A23V2250/1844A23V2250/1846A23V2250/1848A23V2250/185A23V2250/1852A23V2250/1868A23V2250/187A23V2250/5424A23V2250/7052A23V2250/7058A23V2250/706A23L33/14A61K31/44A61K31/4985A61K31/688A61K31/715A61K31/70A61K31/7068A23V2250/308
Inventor 马托伊斯·科内利斯·德维尔德罗伯特·约翰·约瑟夫·哈格曼马丁·格罗宁戴克帕特里克·约瑟夫·赫拉尔杜斯·亨德里克斯·坎普乌斯
Owner NV NUTRICIA
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