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Medicine composition containing sodium L-ascorbate and preparing method of medicine composition

A vitamin and composition technology, applied in the field of pharmaceutical composition and its preparation, can solve problems affecting human health, unstable preparations, adverse reactions, etc., and achieve the effects of reducing the risk of medication, easy operation, and definite curative effect

Inactive Publication Date: 2016-08-10
GUANGXI SANPOTEL HEALTH IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, vitamin C and potassium chloride are clinically used in combination to maintain the basic physiological functions of the human body. When different types of drugs are used in combination, the interaction between drugs and pharmaceutical excipients is prone to unstable preparations, and even adverse reactions and side effects, which affect human health. , in order to avoid the above-mentioned problems, the present invention directly prepares vitamin C and potassium chloride into preparations. Through clinical trials, the preparations are safe and effective. At present, there are no related literature reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of the pharmaceutical composition tablet containing sodium vitamin C comprises the steps:

[0029] S1: Weigh the components according to the following weights: 75 parts of sodium vitamin C, 5 parts of potassium chloride, 1 part of starch, 1 part of sucrose, and 0.5 parts of maltodextrin;

[0030] S2: Crush sodium vitamin C, potassium chloride, starch, sucrose, and maltodextrin into fine powders, and pass through an 80-mesh sieve;

[0031] S3: The sieved fine powder is mixed evenly, granulated, dried, granulated, and tabletted to obtain the product.

Embodiment 2

[0033] The preparation method of the pharmaceutical composition tablet containing sodium vitamin C comprises the steps:

[0034] S1: Weigh the components according to the following weights: 95 parts of sodium vitamin C, 10 parts of potassium chloride, 1.5 parts of starch, 2 parts of sucrose, and 1 part of maltodextrin;

[0035] S2: Crush sodium vitamin C, potassium chloride, starch, sucrose, and maltodextrin into fine powders, and pass through an 80-mesh sieve;

[0036] S3: The sieved fine powder is mixed evenly, granulated, dried, granulated, and tabletted to obtain the product.

[0037] Two, the preparation method that contains vitamin C sodium sterile powder injection

Embodiment 3

[0039] The preparation method of sodium aseptic powder containing vitamin C comprises the following steps:

[0040] S1. Weigh 85 parts of sodium vitamin C and 8 parts of potassium chloride;

[0041] S2. Add the weighed vitamin C sodium and potassium chloride into the water for injection, stir to dissolve it, and obtain a mixed solution;

[0042] S3. The mixed solution is filtered with a microporous membrane with a pore size of 0.22um, and then filtered through a 0.01um ultrafiltration membrane to remove impurities, bacteria and heat sources to obtain a medicinal solution;

[0043] S4. The medicinal solution is spray-dried at a low temperature of 50°C under aseptic conditions to obtain sterile powder, which is then quantitatively dispensed into vials under aseptic conditions, and packed with stoppers and caps.

[0044] Take 1 g of the prepared sample of Example 3, add 10 ml of water at room temperature to dissolve, the sample solution is clear, free of particles, and the measu...

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Abstract

The invention discloses a pharmaceutical composition containing sodium vitamin C and a preparation method thereof. The pharmaceutical composition contains the following components in parts by weight: 75-95 parts of sodium vitamin C, 5-10 parts of potassium chloride, pharmaceutically acceptable 0‑10 parts of accessories. The present invention overcomes the disadvantages of existing vitamin C such as high acidity and easy oxidation, and solves the clinical problem that potassium chloride produced by the combination of vitamin C and potassium chloride accelerates the oxidation of vitamin C, etc., so that the product has better stability and more definite curative effect It is suitable for patients who lack vitamin C and potassium in clinic. It can be used to treat scurvy, infectious diseases, purpura and other diseases with muscle weakness, paralysis, arrhythmia or renal dysfunction. It can also be used for malignant tumors, heart and brain. Prevention and adjuvant treatment of vascular diseases, infectious diseases, autoimmune diseases and other major difficult diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition containing vitamin C sodium and a preparation method thereof. Background technique [0002] Vitamin C is a basic and commonly used drug in clinical practice. It is widely used in the prevention and treatment of various diseases. Since the pH value of vitamin C aqueous solution is close to about 2, it is relatively acidic. Oral use can greatly irritate the oral cavity, throat, esophagus and gastric mucosa, so it is not suitable Long-term use is not suitable for taking with acidic drugs at the same time, and its use is subject to certain restrictions. Vitamin C sodium is the sodium salt of vitamin C. The pH value of the aqueous solution is close to neutral. Its function is the same as that of vitamin C. However, because it is a sodium salt, its performance is more stable. At the same time, it no longer has the strong acidi...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K31/375A61K9/14A61P3/02A61P7/04A61P9/06A61P13/12A61P9/10A61P21/00A61P31/00A61P35/00A61P37/00
CPCA61K33/14A61K9/0019A61K9/143A61K31/375
Inventor 黄爱强钟文粟华生
Owner GUANGXI SANPOTEL HEALTH IND CO LTD
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