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Diamine modified poly-latic acid, method for preparing same and use thereof

A polylactic acid and amine modification technology, which is applied in the field of diamine-modified polylactic acid and its preparation, can solve the problems of accelerating body degradation behavior and not considering acidity, etc., achieve good hydrophilicity, improve hydrophilicity, and excellent hydrophilicity Effects of water and cell affinity

Inactive Publication Date: 2003-08-13
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These chemical modification methods have improved the hydrophilicity and cell affinity of PLA to a great extent, but they have not considered the acidity in the degradation process of the material and the acid-induced autogenesis caused by the acidity generated in the degradation process of PLA. Accelerated Body Degradation Behavior

Method used

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  • Diamine modified poly-latic acid, method for preparing same and use thereof
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  • Diamine modified poly-latic acid, method for preparing same and use thereof

Examples

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Embodiment 1

[0018] Example 1 Preparation of maleic anhydride-modified polylactic acid. Grind 5.0 grams of poly(D, L-lactic acid) (molecular weight is 200,000, static water contact angle θ=51°) and 0.5 grams of maleic anhydride into powder and mix with 15 mg of tert-butyl peroxide evenly, vacuum at room temperature Vacuum fusion seal in 15 ml ampoules after drying for 48 hours. React at 50°C for 20 hours to obtain a colorless and transparent maleic anhydride-modified polylactic acid with a static water contact angle θ=66° (measured by a CQJ-93 contact angle meter, the same below). The product was dissolved in 15 ml of tetrahydrofuran solvent and dropped into excess distilled water to collect the precipitate. Repeat the dissolution-precipitation three times. The precipitate was vacuum-dried at room temperature for 72 hours to obtain 4.2 g of colorless and transparent refined maleic anhydride-modified polylactic acid. Static water contact angle θ=40°, glass transition peak temperature T ...

Embodiment 2

[0019] Example 2 Preparation of maleic anhydride-modified polylactic acid. 5.0 grams of poly (D, L-lactic acid) (molecular weight is 2.2 million, static water contact angle θ = 51 °) and 0.5 grams of maleic anhydride and 15 mg of phthaloyl peroxide were dissolved in 15 milliliters of tetrahydrofuran solvent In a 50 ml round bottom flask, stir well to make the mixture uniform, vacuum dry at room temperature for 48 hours and then vacuum seal. React at 100°C for 10 hours to obtain a colorless or light yellow transparent maleic anhydride-modified polylactic acid with a static water contact angle θ=65° (measured by a CQJ-93 contact angle meter, the same below). The product was dissolved in 15 ml of tetrahydrofuran solvent and dropped into excess distilled water to collect the precipitate. Repeat the dissolution-precipitation three times. The precipitate was vacuum-dried at room temperature for 72 hours to obtain 4.3 g of colorless and transparent refined maleic anhydride-modified...

Embodiment 3

[0020]Example 3 Preparation of ethylenediamine-modified polylactic acid. Dissolve 5.0 grams of poly(D,L-lactic acid) (molecular weight: 2.2 million, static water contact angle θ=51°), 0.25 grams of maleic anhydride and 2.5 mg of tert-butyl peroxide in a 50-ml round-bottomed flask filled with 15 ml of tetrahydrofuran In, stir well to make the mixture even. Vacuum dried at room temperature for 72 hours, and the tetrahydrofuran solvent was sucked off. React at 120°C for 6 hours under the protection of nitrogen to obtain a colorless and transparent maleic anhydride-modified polylactic acid. Add 100 ml of tetrahydrofuran solvent to fully dissolve the maleic anhydride-modified polylactic acid. 0.25 g of ethylenediamine was dissolved in 5 ml of tetrahydrofuran and placed in a constant temperature water bath at 10°C. Add the tetrahydrofuran solution of maleic anhydride-modified polylactic acid dropwise into the tetrahydrofuran solution of ethylenediamine under stirring, and finish ...

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Abstract

A diamine modified polylactic acid, its preparing process and its application in preparing the biodegradable medical materials, especially the tissue engineering material, are disclosed. Its advantages are excellent hydrophilicity and neutral degradation.

Description

technical field [0001] The invention relates to a diamine-modified polylactic acid and its preparation method and application. technical background [0002] One of the core components of tissue engineering is the construction of biocompatible, biodegradable scaffolds that act as temporary supports during vascularization and functional tissue formation. In addition to being able to be processed into complex physical shapes, the ideal tissue engineering scaffold material also needs to be bonded with specific biological signal molecules such as peptides or collagens to endow the material with biospecificity, regulate cell adhesion, growth and differentiation, and make cells Can function correctly. Due to its good biodegradability and biocompatibility, polylactic acid has been widely used in medical implants, surgical sutures, drug controlled release and tissue regeneration, especially as a scaffold material for tissue engineering. However, the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/91
Inventor 王远亮罗彦凤潘君
Owner CHONGQING UNIV
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