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Application of pyrimidine compound to preparing antifungal medicines

A compound and drug technology, applied in the application field of thazolopyrimidine compounds, can solve the problems of easy generation of drug resistance, narrow antibacterial spectrum, large toxic and side effects, etc., and achieve the effect of good antifungal activity and broad antifungal spectrum

Inactive Publication Date: 2014-12-31
SHANGHAI TENTH PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the nitrogen azole compounds that have been reported and are commonly used in clinical practice include Ketoconazole (KCZ), Fluconazole (Fluconazole, FCZ), Vitaconazole ( Voriconazole, VCZ), itraconazole (Itraconazole, ICZ), amphotericin B (Amphotericin B, AMB), etc., but these compounds still have the above-mentioned defects such as large toxic and side effects, narrow antibacterial spectrum, and easy to develop drug resistance, such as The dose required to exert the drug effect is relatively large, so it will cause relatively large toxic and side effects to the human body

Method used

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  • Application of pyrimidine compound to preparing antifungal medicines

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Embodiment 1

[0010] The specific implementation manners provided by the present invention will be described in detail below.

[0011] (1) Experimental method: conventional in vitro antibacterial test method (see: Antimicrob Agents Chemother 1995,39(5):1169 for details)

[0012] 1. Materials and Methods

[0013] (1) The compound to be tested in the present invention: N3-(4-fluorophenyl)-1H-pyrazolo[3,4-D]pyrimidine-3,4-diamine

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Abstract

The invention relates to the technical field of application of pyrazolopyrimidine compounds to preparing medicines for diseases infected by cryptococcus neoformans and aims to provide application of a pyrazolopyrimidine compound. In order to achieve the aim, the invention adopts the technical scheme that the pyrazolopyrimidine compound is N3-(4-fluorophenyl)-1H-pyrazolo[3,4-D]pyrimidine-3,4-diamine. According to the invention, the compound has a favorable antifungal activity on various superficial and deep fungi, has the advantages of high efficacy, low toxicity, wide antifungal spectrum and the like as compared with the conventional clinical antifungal medicines, and can be used for preparing antifungal medicines.

Description

technical field [0001] The present invention relates to the application of a compound, in particular to the application of a thalazopyrimidine compound. Background technique [0002] Fungal infectious diseases are divided into four categories according to the parts of the fungus that invade the human body: superficial mycosis, skin mycosis, subcutaneous tissue mycosis and systemic mycosis; the former two are collectively called superficial mycosis, and the latter two are also called For deep mycoses. Fungal infectious diseases are divided into the following types according to different fungi: Candida albicans infectious disease, Candida parapsilosis infectious disease, Candida glabrata infectious disease, Cryptococcus neoformans infectious disease, plaster Microsporum infectious disease, Trichophyton rubrum infectious disease, Aspergillus fumigatus infectious disease. [0003] In recent years, with the wide application of broad-spectrum antibiotics, corticosteroids and imm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P31/10
Inventor 李国才
Owner SHANGHAI TENTH PEOPLES HOSPITAL