Adprin preparation for resisting coccidiosis and preparation method

A technology of adefoline and anticoccidia, which is applied in the direction of anti-infective drugs, powder delivery, active ingredients of heterocyclic compounds, etc. It can solve the problems that the concentration of active ingredients of drugs cannot be guaranteed, coccidiosis cannot be completely controlled, and solution transportation High cost and other issues, to achieve the effect of improving bioavailability, suitable for large-scale production, and reducing reinfection

Inactive Publication Date: 2013-12-04
HENAN SOAR VETERINARY PHARMA
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Adefurin belongs to a new type of coccidiostat drug, which is insoluble in water and is mainly administered in the form of mixing materials. There are serious inconveniences in the process of use. The currently known adefurin solution is relatively stable in water. Poor, easy to separate out, can not guarantee the concentration of active ingredients in the water, so can not achieve the corresponding curative effect; at the same time, the solution has the defects of high transportation cost and special packaging conditions, and the prevention and control of coccidiosis adopts group control, which requires Group drug administration. At present, large-scale farms use fully formulated full-price feed, and it is difficult to add drugs to the feed. Therefore, some excellent anticoccidiostats cannot be widely promoted in clinical practice.
The above reasons are the factors that lead to the incomplete control of coccidiosis in the breeding process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Weigh 12 grams of adfuroline, 68 grams of PEG6000, 18 grams of anhydrous citric acid, and 2 grams of sodium citrate, then mix the above raw materials evenly, heat them in a heat-resistant container until they melt, and quickly cool them under vigorous stirring to 25°C, put it in a desiccator, take it out, crush it, and sieve it to get the finished product.

Embodiment 2

[0014] Weigh 10 grams of adfuroline, 73 grams of PEG6000, 15 grams of anhydrous citric acid, and 2 grams of sodium citrate respectively, mix the above materials evenly, put them into a heat-resistant container and heat to melt, and quickly cool to 15°C, put it in a desiccator, wait until the temperature returns to room temperature, take it out, crush it, and sieve it to get the finished product.

Embodiment 3

[0016] Weigh 6 grams of adfuroline, 82 grams of PEG6000, 9 grams of oxalic acid, and 3 grams of sodium lauryl sulfate respectively, mix the above materials evenly, put them into a heat-resistant container and heat to melt, and quickly cool to Put it in a desiccator at 20°C, wait until the temperature returns to room temperature, take it out, crush it, and sieve it to get the finished product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

An adprin preparation for resisting coccidiosis comprises the following components, by mass, 4%-20% of adprin, 60%-85% of carrier and 6%-30% cosolvent. According to the adprin preparation for resisting the coccidiosis, the carrier is used for being combined with the cosolvent to enable the adprin to exist in a solid dispersion form, the adprin can be dispersed in water evenly and stably, the character is stable, and bioavailability is improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to an anti-coccidial adfuroline preparation and a preparation method thereof. Background technique [0002] In today's veterinary clinic, the prevention and treatment of coccidiosis is facing serious problems of drug resistance and practicality. In addition to drug resistance, conventional anticoccidial drugs such as sulfonamides and polyether ion drugs also have toxic side effects and food Security restrictions and other issues. Although traditional Chinese medicine extracts such as anticoccidial drugs such as hemosanone and artemisinin have low toxicity, they are expensive and difficult to promote in clinical practice. Studies have confirmed that the mechanism of action of adefoline is to affect the utilization of purines and pyrimidines by coccidia, reduce the synthesis of nucleic acids, and hinder the growth and reproduction of worms. It has a ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/52A61K47/34A61P33/02
Inventor 杨振豪赵战军李灵娟
Owner HENAN SOAR VETERINARY PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap