Adprin preparation for resisting coccidiosis and preparation method

Abstract

An adprin preparation for resisting coccidiosis comprises the following components, by mass, 4%-20% of adprin, 60%-85% of carrier and 6%-30% cosolvent. According to the adprin preparation for resisting the coccidiosis, the carrier is used for being combined with the cosolvent to enable the adprin to exist in a solid dispersion form, the adprin can be dispersed in water evenly and stably, the character is stable, and bioavailability is improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to an anti-coccidial adfuroline preparation and a preparation method thereof. Background technique [0002] In today's veterinary clinic, the prevention and treatment of coccidiosis is facing serious problems of drug resistance and practicality. In addition to drug resistance, conventional anticoccidial drugs such as sulfonamides and polyether ion drugs also have toxic side effects and food Security restrictions and other issues. Although traditional Chinese medicine extracts such as anticoccidial drugs such as hemosanone and artemisinin have low toxicity, they are expensive and difficult to promote in clinical practice. Studies have confirmed that the mechanism of action of adefoline is to affect the utilization of purines and pyrimidines by coccidia, reduce the synthesis of nucleic acids, and hinder the growth and reproduction of worms. It has a ...

AI Technical Summary

Problems solved by technology

[0003] Adefurin belongs to a new type of coccidiostat drug, which is insoluble in water and is mainly administered in the form of mixing materials. There are serious inconveniences in the process of use. The currently known adefurin solution is relatively stable in water. Poor, easy to separate out, can not guarantee the concentration of active ingredients in the water, so can not achieve the corresponding curative effect; at the same time, the solution has the defects of high transportation cost and special packaging conditions, and the prevention and control of coccidiosis adopts group control, which requires Group drug administration. At present, large-scale farms use fully formulated full-price feed, and it is difficult to add drugs to the feed. Therefore, some excellent anticoccidiostats cannot be widely promoted in clinical practice.

The above reasons are the factors that lead to the incomplete control of coccidiosis in the breeding process