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Composite multifunctional biological hemostatic material and preparation method thereof

A technology of hemostatic materials and biomaterials, which is applied in the field of medical devices and can solve the problems of no hemostatic materials

Active Publication Date: 2013-12-04
JIANGSU HAIZE MEDICAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no tissue engineering material for trauma repair of deep organs that has been applied clinically, which can promote tissue regeneration, reduce scar repair, and restore the shape and function of tissues and organs to the greatest extent. Hemostatic material for regenerative repair

Method used

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  • Composite multifunctional biological hemostatic material and preparation method thereof
  • Composite multifunctional biological hemostatic material and preparation method thereof
  • Composite multifunctional biological hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Prepare 5wt% silk fibroin aqueous solution with a molecular weight of 5000, pour it into the mold, adjust the freezing rate of the freeze dryer to 0.1°C / min, freeze-drying temperature -45°C, freeze-drying and drying time for 2 hours, sublimation The temperature is 10°C, and finally the temperature is raised to 30-40°C until the pressure is 0.5 Pa / min, and the freeze-drying process is completed to obtain a silk fibroin scaffold (that is, a porous tissue cell growth scaffold). The scanning electron microscope picture is shown in figure 1 .

[0035](2) Prepare 4wt% chitosan aqueous solution with a molecular weight of 10,000, soak the silk fibroin support prepared in the previous step in the chitosan aqueous solution, place them in the mold together, and adjust the freezing rate of the freeze dryer at 2°C / The freeze-drying temperature is -15°C, the freeze-drying drying time is 3 hours, the sublimation temperature is 20°C, and finally the temperature is raised to 30-40°...

Embodiment 2

[0037] (1) Prepare 20wt% silk fibroin aqueous solution with a molecular weight of 8000, pour it into the mold, adjust the freezing rate of the freeze dryer to 1°C / min, freeze-drying temperature -30°C, freeze-drying and drying time for 4 hours, sublimation The temperature is 15°C, and finally the temperature is raised to 30-40°C until the pressure is 2Pa / min, and the freeze-drying process is completed to obtain a silk fibroin scaffold (that is, a porous tissue cell growth scaffold). The scanning electron microscope picture is shown in image 3 .

[0038] (2) Prepare 30wt% chitosan aqueous solution with a molecular weight of 30,000, soak the silk fibroin support prepared in the previous step in the chitosan aqueous solution, place them in the mold together, and adjust the freezing rate of the freeze dryer to 1.5°C / The freeze-drying temperature is -30°C, the freeze-drying drying time is 2.5 hours, the sublimation temperature is 10°C, and finally the temperature is raised to 30-4...

Embodiment 3

[0040] 1) Prepare 20wt% silk fibroin aqueous solution with a molecular weight of 8000, pour it into the mold, adjust the freezing rate of the freeze dryer to 1°C / min, the freeze-drying temperature to -30°C, the freeze-drying time to 4 hours, and the sublimation temperature 15°C, and finally raise the temperature to 30-40°C until the pressure is 2Pa / min, complete the freeze-drying process, and obtain the silk fibroin scaffold (that is, the porous tissue cell growth scaffold).

[0041] 2) prepare 30wt% molecular weight chitosan aqueous solution of 30,000, which contains 5wt% PVP, soak the silk fibroin support prepared in the previous step in the chitosan aqueous solution, place them in the mold together, and adjust the freeze dryer The freezing rate is 1.5°C / min, the freeze-drying temperature is -30°C, the freeze-drying drying time is 2.5 hours, the sublimation temperature is 10°C, and finally the temperature is raised to 30-40°C until the pressure is 2Pa / min. Silk fibroin-chito...

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Abstract

The invention belongs to the field of medical equipment and relates to a composite multifunctional biological hemostatic material and a preparation method thereof. A porous tissue engineering cell growth stent made of silk fibroin is used as a core; pores of a porous network of the stent are filled withbiological hemostatic material mainly made of chitosan; the composite multifunctional biological hemostatic material can be obtained by connecting the silk fibroin and the chitosan via hydrogen bonds. The composite multifunctional biological hemostatic material has the function of local hemostasis for injury and the function of promoting regeneration of injured tissue cells.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a composite multifunctional biological hemostatic material and a preparation method thereof. Background technique [0002] When human tissue is damaged, tissues and organs are damaged, hemorrhage, and inflammatory response occurs. The damaged tissue releases bioactive substances such as tissue factor, activates the exogenous coagulation system and platelets, damages local thrombus formation and stops bleeding. The hemostatic materials currently used clinically are mainly made of chitosan, oxidized regenerated cellulose, collagen, etc., which help hemostasis through local compression and promotion of thrombus formation. Tissue damage is repaired through regeneration. Regeneration is to repair the same kind of cells around it. If the structure and function of the original tissue are completely restored, it is called complete regeneration. However, if there is an injury and the injur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L27/22A61L27/20A61L27/54
Inventor 钱建民黄秀娟陈丽丽
Owner JIANGSU HAIZE MEDICAL TECH DEV
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