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Multi-variant and multi-phase salvia miltiorrhiza solid self-microemulsion, application thereof in preparation of drug and preparation method thereof

A technology of self-microemulsion and phase salvia miltiorrhiza, which is applied in the field of medicine, can solve problems such as inconvenient administration, poor stability of ordinary microemulsion, and toxic and side effects of surfactants.

Inactive Publication Date: 2013-12-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor stability of ordinary microemulsions, the inconvenience of taking and the toxic and side effects caused by the need for a large amount of surfactants, some problems are faced in the actual preparation of drugs, and it is necessary to find new non-toxic excipients to optimize the appropriate ratio and use a suitable preparation process to solve these problems

Method used

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  • Multi-variant and multi-phase salvia miltiorrhiza solid self-microemulsion, application thereof in preparation of drug and preparation method thereof
  • Multi-variant and multi-phase salvia miltiorrhiza solid self-microemulsion, application thereof in preparation of drug and preparation method thereof
  • Multi-variant and multi-phase salvia miltiorrhiza solid self-microemulsion, application thereof in preparation of drug and preparation method thereof

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Effect test

Embodiment 1

[0044] Embodiment 1: the method for preparing a kind of multi-component multiphase salvia miltiorrhiza solid self-microemulsion preparation, its composition is as follows:

[0045]

[0046] The method includes the following steps: mixing the prescribed amount of medicine and auxiliary materials, adding ten times the amount of water, magnetically stirring, mixing evenly until clear and transparent, subpackaging, freezing at minus 40°C, and putting into a freeze dryer for freeze drying. After drying, the obtained powder is filled, sterilized, numbered, and the product is obtained.

Embodiment 2

[0048]

[0049]

[0050] The method includes the following steps: mixing the prescribed amount of medicine and auxiliary materials, adding ten times the amount of water, magnetically stirring, mixing evenly until clear and transparent, subpackaging, freezing at minus 40°C, and putting into a freeze dryer for freeze drying. After drying, the obtained powder is filled, sterilized, numbered, and the product is obtained.

Embodiment 3

[0052]

[0053] The method includes the following steps: mixing the prescribed amount of medicine and auxiliary materials, adding ten times the amount of water, magnetically stirring, mixing evenly until clear and transparent, subpackaging, freezing at minus 40°C, and putting into a freeze dryer for freeze drying. After drying, the obtained powder is filled, sterilized, numbered, and the product is obtained.

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Abstract

The invention discloses a multi-variant and multi-phase salvia miltiorrhiza solid self-microemulsion, application thereof in preparation of a drug and a preparation method thereof. A solid self-microemulsion composition is prepared from the following components by weight: 0.1-10g of salvia miltiorrhiza multi-component extract, 10-30g of emulsifier, 5-20g of co-emulsifier, 10-30g of oil phase and 20-50g of solid adsorbent. Two components (total tanshinones and salvianolic acids) in the salvia miltiorrhiza are simultaneously loaded to one preparation; in vivo absorption of a plurality of ingredients in the salvia miltiorrhiza is improved. By adopting the preparation method, the stability of the self-microemulsion preparation can be increased; the dosage of a surfactant is greatly reduced; meanwhile, the bioavailability of a multi-component extract of the salvia miltiorrhiza is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a multi-component heterogeneous Dan solid self-microemulsion for anti-cardiovascular disease, its application in preparing medicine and its preparation method. That is to improve the stability and bioavailability of the multi-component extract of Danshen by preparing multi-component multi-phase solid self-microemulsion. technical background [0002] Salvia miltiorrhiza is the dried root and rhizome of Salvia miltiorrhiza Bge, a plant in the Labiatae family. It has the effects of dispelling stasis and relieving pain, promoting blood circulation and regulating menstruation, clearing heart and eliminating troubles, and is widely used clinically for cardiovascular and cerebrovascular diseases. The active parts of Danshen that have the activity of promoting blood circulation and removing stasis mainly fall into two categories, namely, fat-soluble diterpene ketone compounds Tanshinone I...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/107A61P7/02A61P9/10
Inventor 狄留庆刘璇毕肖林
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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