Bromo-butanone synthesis method

A technology of bromobutanone and methyl oxopentanoate, applied in the field of biomedicine, can solve problems such as hindering the development and development of downstream products, and achieve the effects of easy promotion, easy availability of raw materials and low price
CN103449992AInactive Publication Date: 2013-12-18TIANJIN QUANHECHENG TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN QUANHECHENG TECH
Publication Date
2013-12-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel bromo-butanone synthesis method. In the method, 3-methyl propionlyacetae is used as a start raw material; a key intermediate is obtained by chlorination and degreasing reactions, wherein the yield is greater than 70%; the bromo-butanone is obtained by bromination, wherein the total yield is greater than 50%. The method provided by the invention can overcome the adverse factors in the enlarged production of bromo-butanone, and has the characteristics of cheap raw materials, short path, no use of dangerous reagent, high yield and the like so that the product can be produced in a large scale and is cheap and convenient to popularize.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a method for synthesizing a drug intermediate. Background technique

[0002] Bromobutanone is an important biopharmaceutical intermediate, which can be widely used in the synthesis of various drugs. It has a small molecular weight and a unique structure, and can be derived from a variety of downstream products, so it has a wide range of uses. At present, there is no good scale-up production method for the synthesis of bromobutanone, which seriously hinders the development of its downstream products and its further development in the field of biomedicine. Contents of the invention

[0003] The technical problem solved by the present invention is to provide a new method for synthesizing bromobutanone, which can overcome various unfavorable factors in the enlarged production of bromobutanone, and has the advantages of low raw material, short route, no use of dangerous reagents, and hig...

Claims

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