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Application of racemosins A in preparation of medicine treating rhinitis

A drug and rhinitis technology, applied in the field of application of Racemosins A in the preparation of drugs for the treatment of rhinitis, which can solve the problems of ineffectiveness and poor curative effect of rhinitis

Inactive Publication Date: 2013-12-25
段仲达
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used in the treatment of rhinitis. These drugs have poor or ineffective effects on chronicity and recurrent rhinitis

Method used

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  • Application of racemosins A in preparation of medicine treating rhinitis
  • Application of racemosins A in preparation of medicine treating rhinitis
  • Application of racemosins A in preparation of medicine treating rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: The preparation of the compound Racemosins A tablet involved in the present invention:

[0013] Take 5 grams of compound Racemosins A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Racemosins A capsules involved in the present invention:

[0015] Take 5 grams of compound Racemosins A, add 180 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Racemosins A of the present invention on ovalbumin-induced allergic rhinitis in rats

[0018] Male SD rats, weighing 180-220 g, were intraperitoneally injected with 1 mg of ovalbumin and 10 mg of aluminum hydroxide gel, and then injected once every other day, a total of 7 times. From the 14th day, 10ul of 1mg / ml ovalbumin physiological saline solution was instilled into the nasal cavities of both sides of the rat every day, 7 times in total. Immediately after the last infusion, observe the number of times the rats sneeze and wipe their noses within 30 minutes, and the test drug is orally administered 1 hour before the last infusion of ovalbumin.

[0019] Table 1 Effect of Racemosins A of the present invention on ovalbumin-induced allergic rhinitis in rats (x±SD)

[0020]

[0021] Compared with the control group, **P<0.01*P<0.05

[0022] It can be seen from Table 1 that Racemosins A (10, 20mg / kg) significantly inhibited the s...

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PUM

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Abstract

Racemosins A treating immune inflammation is used for preparing the medicine treating the immune inflammation and is especially suitable for preparing the medicine treating the rhinitis. Compared with terfenadine and diclofenac sodium, the racemosins A is good in therapeutic effect. The application of the racemosins A in preparation of the medicine treating the rhinitis is disclosed for the first time. The matrix type of the racemosins A belongs to a brand new matrix type. The racemosins A has the advantages of being high in activity for treating the rhinitis and prominent in substantive features, and makes remarkable progress in preventing and treating the rhinitis.

Description

technical field [0001] The invention relates to a new application of the compound Racemosins A, in particular to the application of the Racemosins A in the preparation of a medicine for treating rhinitis. Background technique [0002] Rhinitis is a common and frequently-occurring disease in clinical practice. The occurrence of rhinitis is mainly related to allergic reactions and belongs to the category of immune inflammation. At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used for the treatment of rhinitis, and these drugs have poor or ineffective effects on chronicity and recurrent rhinitis. Therefore, small molecular compounds with clear components, quality control, safety and high efficiency have potential value in the development of drugs for rhinitis treatment. [0003] The compound Racemosins A involved in the present invention is a compound published in 2013 (J Ding-Quan Liu, et al., Racemosins A a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P11/02A61P29/00
Inventor 段仲达
Owner 段仲达
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