Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of azide compounds and compounds, which is applied in the field of catalytic synthesis of organic matter, can solve the problems of high ligand toxicity, large amount of copper application, and inconformity with the concept of green production, and achieve simple catalytic system, convenient operation, and overcome the high toxicity of ligands Effect
Inactive Publication Date: 2015-07-01
HENAN NORMAL UNIV
View PDF4 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
There are many catalytic systems for cycloaddition reactions, which can be divided into three types according to the valence state of the catalyst Cu: Cu(0), Cu(I), and Cu(II). Therefore, the study of green synthesis methods has become one of the research hotspots of cycloaddition reactions.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0010] 4-Benzyloxy-1-phenyl-1H-1,2,3-triazole
[0011]
[0012] Weigh copper acetate (1mmol) and pullulan (10mmol), dissolve completely in water, and add propargyl phenyl ether (100mmol) and phenyl azide (100mmol) at a temperature of 70°C under stirring conditions, Keep the temperature until the end of the reaction. After cooling, a solid precipitates out. Filter and purify to obtain 4-benzyloxy-1-phenyl-1H-1,2,3-triazole.
[0016] Weigh copper acetate (1mmol) and pullulan (1mmol), dissolve completely in water, and add propargyl phenyl ether (100mmol) and p-methoxyphenyl azide at a temperature of 80°C under stirring conditions (100mmol), keep the temperature until the end of the reaction, after cooling, a solid precipitates out, filters and purifies to obtain 4-benzyloxy-1-p-methoxyphenyl-1H-1,2,3-triazol azole.
[0020] Weigh copper acetate (1mmol) and pullulan (0.1mmol), dissolve completely in water, and add propargyl p-chlorophenyl ether (100mmol) and o-methylphenyl Azide (100mmol), keep the temperature until the end of the reaction, after cooling, solids precipitate out, filter and purify to obtain 4-(4-chloro-benzyloxy)-1-o-tolyl-1H-1,2 ,3-triazole.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses a method for preparing a 1, 2, 3-triazole compound. The technical scheme of the invention is as follows: the method for preparing the 1, 2, 3-triazole compound comprises the following steps: (1), weighing copper acetate and Pullulan respectively, fully dissolving the copper acetate and the Pullulan in water, wherein the copper acetate is Cu(OAc)2.H2O; and (2), adding a terminal alkyne compound and an azide compound at 70-100 DEG C while stirring, keeping the temperature till the end of reaction, cooling, separating out a solid, filtering, and purifying to obtain the 1, 2, 3-triazole compound. The using amount of the copper in a catalytic system is reasonable and the defect that a ligand is high in toxicity is overcome, so that the method for preparing the 1, 2, 3-triazole compound is an environment-friendly method.
Description
technical field [0001] The invention belongs to the field of catalytic synthesis of organic matter, and in particular relates to a method for preparing 1,2,3-triazole compounds by using copper acetate / pullulan as a catalytic system. Background technique [0002] Nitrogen-containing heterocyclic compounds have important application value and good biological activity. Many heterocyclic compounds have been developed into new drugs and pesticides. Their synthesis, structure optimization and development research are currently research hotspots in organic chemistry and pesticide chemistry. Azole compounds are the largest clinically used antifungal drugs. Compounds containing 1,2,3-triazoles exhibit diverse biological activities, such as antiallergic, antibacterial, antiviral, antituberculosis, etc. 1,2,3-Triazole is a very attractive group, it has high aromatic stability, is stable to metabolism, the presence of hydrogen bonds leads to good binding ability with biological target ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more