42results about How to "The catalytic system is simple" patented technology

The invention discloses a method for preparing a 1, 2, 3-triazole compound. The technical scheme of the invention is as follows: the method for preparing the 1, 2, 3-triazole compound comprises the following steps: (1), weighing copper acetate and Pullulan respectively, fully dissolving the copper acetate and the Pullulan in water, wherein the copper acetate is Cu(OAc)2.H2O; and (2), adding a terminal alkyne compound and an azide compound at 70-100 DEG C while stirring, keeping the temperature till the end of reaction, cooling, separating out a solid, filtering, and purifying to obtain the 1, 2, 3-triazole compound. The using amount of the copper in a catalytic system is reasonable and the defect that a ligand is high in toxicity is overcome, so that the method for preparing the 1, 2, 3-triazole compound is an environment-friendly method.

The invention provides an olefin polymerization catalyst composition comprising a nitrogen-containing heterocyclic ligand compound as shown in formula I, a transition metal compound and a cocatalyst; and R1, R2, R3 and R4 can be independently selected from hydrogen, alkyl, or alkoxy. The invention also provides an application method of the catalyst composition, including olefin polymerization of olefins in the presence of the catalyst composition and an organic solvent in a reactor.

The invention discloses a preparation method of 1,2,3-triazole compound and belongs to the field of medicament catalyzed synthesis technology. The technical scheme is characterized in that according to the preparation method of the 1,2,3-triazole compound, an end group alkyne compound and organic trinitride are respectively used as raw materials; pullulan triazole/cuprous chloride is used as a catalytic system; water is used as a solvent; the 1,2,3-triazole compound is prepared through mixed stirring reaction under the condition of the room temperature of minus 100 DEG C. According to the preparation method, pullulan polymer cotaining triazole group is applied to Huisgen cycloaddition reaction to be used as an additive to stabilize cuprous ions so that use level of catalyst in the catalytic reaction process is reduced. The catalytic system is mainly subjected to catalytic reaction in water, simple, reliable, high in yield, easy to separate, reusable, green, environmentally friendly, and the like.

The invention discloses a method for preparing aldehyde or ketone by copper salt/bidentate ligand/TEMPO catalytic air oxidation alcohol. The alcohol is used as a raw material, an organic solution is used as a solvent, and the air is used as an oxidant. The raw material alcohol is oxidized to obtain the corresponding aldehyde or ketone under the catalysis of the copper salt/ bidentate ligand /TEMPO. The copper salt/bidentate ligand/TEMPO catalytic air oxidation alcohol is utilized. A technical route has the advantages of simplifying a catalytic system, being simple in operation, good in substrate applicability, high in yield, low in cost and easy to industrialize, so that the method is a very economical simple method for preparing the aldehyde or the ketone from the alcohol.

The invention relates to a synthetic method of aryl-alkyl thioether. According to the synthetic method, with aryl metal organic sulfinate (ArSO2M or (ArSO2)2M) as an arylation reagent and alkyl sulfhydryl as a reaction substrate, aryl-alkyl thioether is obtained under the actions of catalyzer and alkali. The aryl metal organic sulfinate is sodium salt, kali salt, lithium salt, silver salt, zinc salt and copper salt of aryl sulfinate. The aryl metal organic sulfinate is a arylation reagent with high efficiency and good universality.

The invention discloses a photocatalytic synthesis method of a C2 substituted 2H-benzothiazole hydroxyl alkylation derivative. The method comprises the following steps of: mixing substituted 2H-benzothiazole shown as a formula (II) with fatty alcohol shown as a formula (III), adding an oxidizing agent Selectfluor, an additive trifluoroacetic acid and a solvent acetonitrile, and carrying out a normal temperature stirring reaction under the protection of nitrogen and the irradiation of an LED blue light lamp; carrying out TLC monitoring until the reaction is finished, and carrying out separationand purification on the reaction liquid to obtain the C2-substituted 2H-benzothiazole hydroxyalkylated derivative represented by formula (I). The invention provides a new method for synthesizing the2H-benzothiazole C2 hydroxyalkylated derivative through visible light induction by taking Selectfluor as an oxidizing agent, trifluoroacetic acid as an additive and acetonitrile as a solvent. The method is simple in catalytic system, mild in reaction condition and wide in substrate range.

The invention discloses a preparation method of a C2 substituted 2Hbenzothiazole acylation derivative. The preparation method comprises the following steps: mixing 2Hbenzothiazole with substituted methyl benzene, adding an oxidizing agent K2S2O8, reacting in an air atmosphere, carrying out TLC (Thin Layer Chromatography) monitoring until the reaction is finished, and separating and purifying the reaction solution to obtain the C2 substituted 2Hbenzothiazole acylation derivative. By the adoption of the technology, K2S2O8 serves as an oxidizing agent, the C2-substituted 2Hbenzothiazole acylationderivative is synthesized through a heating reaction in the air atmosphere, and the method is simple in catalytic system, good in product yield, wide in substrate range and suitable for application and popularization.

The invention discloses a C2 substituted 2H-benzothiazole aryl acylated derivative, and a synthesis method and application thereof. The preparation method of the derivative comprises the following steps: mixing substituted 2H-benzothiazole and substituted methyl benzene, adding into a solvent, in the presence of an oxidizing agent Selectfluor and an additive trifluoroacetic acid, carrying out a heating and stirring reaction in the air atmosphere, performing TLC monitoring is conducted till the reaction is finished, and separating and purifying the obtained reaction liquid to obtain the target product C2 substituted 2H-benzothiazole aryl acylated derivative. The substituted methyl benzene used in the invention is low in price, easy to obtain and good in chemical stability, the method has the advantages of being high in atom economy, simple in catalytic system, free of transition metal catalysts, good in product yield, wide in substrate range and the like, and the prepared compound structure can be further optimized as an anti-tumor drug lead.

The invention discloses a mild photocatalytic synthesis method of a C2 ether substituted 2H-benzothiazole derivative. The preparation method comprises the following steps: mixing 2H-benzothiazole shown as a formula (II) with ether shown as a formula (III); adding an oxidizing agent Selectfluor, an additive trifluoroacetic acid and a solvent acetonitrile, carrying out a normal temperature stirringreaction under the protection of nitrogen and the irradiation of an LED blue light lamp, carrying out TLC monitoring until the reaction is finished, and carrying out separation and purification on thereaction liquid to obtain the C2 ether substituted 2H-benzothiazole derivative represented by the formula (I). The invention provides a new method for synthesizing the C2 ether substituted 2H-benzothiazole derivative through visible light induction by taking Selectfluor as an oxidizing agent, trifluoroacetic acid as an additive and acetonitrile as a solvent, and the method has the advantages of simple catalytic system, mild reaction conditions, wide substrate range and the like.

The invention discloses a preparation method of a nitro-substituted indole compound. The method comprises the following steps: mixing a dinitrobenzene compound and an enaminone compound according to amolar ratio of (1-3): (1-3); carrying out a stirring reaction on the mixture in an air atmosphere at a temperature of 25-150 DEG C in the presence of m-dichlorobenzene (MCB) as a solvent and an alkali promoter for 12-24 h; carrying out TLC detection to determine the reaction process, and after the reaction is finished, washing the reaction solution with water, extracting, drying and carrying outcolumn chromatography separation to obtain a target product. The method provided by the invention has the advantages of cheap and easily available raw materials, simple and mild catalytic conditions,convenient post-treatment, a high yield and the like, and the obtained product has good economic added value and certain economic benefits.

The invention belongs to the technical field of pharmaceutical chemistry, and discloses a Toddacoumalone compound or a pharmaceutically acceptable salt and a preparation method and application thereof. The general formula of the molecular structure of the Toddacoumalone compound is shown in the formula I or the formula II or formula II. The provided Toddacoumalone compound has good anti-phosphodiesterase 4 activity. According to the preparation method of the Toddacoumalone compound, a simple and easy-to-obtain quinolinone substrate and an aldehyde compound are used as raw materials, the reaction step is short, and the yield is relatively high. The preparation method has the advantages that the reaction substrate is easy to obtain, a catalytic system is simple, operation is simple, the functional group tolerance is good, the compound is economical and effective and the product structure is diversified and has very important academic value and further application and popularization significance.

The invention discloses a preparation method of cyclic carbonate and a preparation method of a catalyst, and belongs to the technical field of green catalytic synthesis. The invention designs an artificially synthesized organic catalyst derived from a natural alpha-amino acid raw material. R2 groups in the catalyst are side chain R groups of glycine, valine, phenylglycine and phenylalanine, a catalyst structure with better activity is obtained through a preliminary screening experiment, R1 and R3 groups in the catalyst structure are further modified, and the catalyst with optimal activity is screened out. Finally, through reaction condition optimization and substrate range screening, the efficient catalytic activity of the organic catalyst for catalyzing epoxide to prepare cyclic carbonate under mild conditions is verified.

The invention belongs to the technical field of acid anhydride preparation, and particularly relates to a method for preparing acid anhydride through catalytic dehydration of a carboxylic acid compound. According to the preparation method, under the condition that an N-N bidentate ligand is adopted as a catalyst, a carboxylic acid compound is heated in an inert solvent, intramolecular dehydration condensation of the carboxylic acid compound is catalyzed, and the target anhydride compound is obtained at a high yield. The method has the advantages that the catalytic system is simple, the catalytic effect is good when the catalyst amount is small, and the substrate adaptability is good; the reaction speed and the conversion rate are high; the method has the advantages of simple reaction operation and post-treatment steps, mild conditions, solvent recovery and repeated use, no pollution in the reaction process and the like, can be widely used for production and application, and has great significance in the synthesis field of carboxylic acid anhydride.

The invention belongs to the technical field of organic synthetic chemistry. According to the method, ethyl diazoacetate and arylboronic acid are used as coupling reagents and a 1,1-arylation alkylation reaction is carried out with catalysis of copper, thereby synthesizing the important (E)-beta-aryl-beta,gamma-unsaturated ester in one step. The method specifically comprises the following steps:mixing an alkyne compound, a solvent, ethyl diazoacetate, an arylboronic acid compound, phenanthroline, CuI and K3PO4, then carrying out closed reaction for 1.2-3 hours at 90-110 DEG C in an inert gasatmosphere; and after the reaction is finished, carrying out post-treatment to obtain the product. The method has the characteristics of simple catalytic system, cheap and easily available raw materials, excellent functional group compatibility, high region and chemical selectivity, wide substrate application range and the like, and is suitable for synthesizing various (E)-beta-aryl-beta,gamma-unsaturated ester compounds.