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Application of lycojaponicumin B in the preparation of anti-tuberculosis drugs

A technology for anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effect of highlighting substantive features, broad application prospects, and strong inhibitory activity against tuberculosis

Active Publication Date: 2015-09-16
王晓燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of lycojaponicumin B in the preparation of anti-tuberculosis drugs
  • Application of lycojaponicumin B in the preparation of anti-tuberculosis drugs
  • Application of lycojaponicumin B in the preparation of anti-tuberculosis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of the compound Lycojaponicumin B tablet involved in the present invention:

[0017] Take 20 grams of compound Lycojaponicumin B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0018] Embodiment 2: the preparation of the compound Lycojaponicumin B capsules involved in the present invention:

[0019] Get 20 grams of compound Lycojaponicumin B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental Example 1 Solid Medium Dilution Method Determination of Lycojaponicumin B Anti-Bacillus Calmette-Guerin (BCG) Absolute Concentration

[0022] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate vigorously on the vortex shaker, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1 ) turbidity, that is, to prepare 1 mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0023] Make Lycojaponicumin B into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Lycojaponicumin B to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Lycojaponicumin B, the concentrations are 6.0ug / ml,...

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Abstract

The invention discloses application of Lycojaponicumin B in the preparation of anti-mycobacterium tuberculosis drugs. Aiming at the phenomenon that at present, tuberculosis incidence is high and multi-drug resistant mycobacterium tuberculosis strains appear, so that the incidence and mortality rates of tuberculosis are on the rise, the invention discovers that the Lycojaponicumin B has remarkable activity of inhibiting mycobacterium tuberculosis, and has a good application prospect. The application of the Lycojaponicumin B in the preparation of the anti-mycobacterium tuberculosis drugs is disclosed for the first time. The Lycojaponicumin B has the advantages that the skeleton type belongs to an unprecedented skeleton type, and the inhibitory activity on mycobacterium tuberculosis is unexpectedly high, so that the probability that other compounds give enlightenments does not exist. The Lycojaponicumin B has an outstanding substantial characteristic, and meanwhile makes remarkable progress in preventing mycobacterium tuberculosis infection.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Lycojaponicumin B in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/424A61P31/06
Inventor 江春平吴俊艺
Owner 王晓燕
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