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Preparation method of decoquinate dry suspension

A decoquinate and dry suspension technology, applied in the field of preparation of decoquinate dry suspension, can solve the problems of inability to administer by drinking water, complicated preparation process, inconvenient use, etc., and achieve convenient clinical drinking water. The effect of simple administration and preparation process

Active Publication Date: 2014-01-08
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the decoquinate premix can only be administered through mixing materials and cannot be administered through drinking water, which is inconvenient to use and greatly limits its clinical use.
In 2009, the Ministry of Agriculture of my country approved the production of decoquinate solution, but the solution has shortcomings such as large amount of organic solvent used, complicated preparation process, and instability to light.
not easy to store
[0013] "A dry suspension formulation containing decoquinate and its preparation method" (102274189A; publication date: December 14, 2011) In the preparation process, solid dispersion carriers (β-cyclodextrin, hydroxypropyl β-cyclodextrin, polyethylene glycol 4000, polyethylene glycol 6000), crushed, because the solid dispersion carrier is a macromolecular substance, it is easy to agglomerate at high temperature, which affects the crushing efficiency, requires high equipment and high cost

Method used

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  • Preparation method of decoquinate dry suspension
  • Preparation method of decoquinate dry suspension
  • Preparation method of decoquinate dry suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Decoquinate dry suspension formulation:

[0033]

[0034] Preparation method:

[0035] (1) Weigh 0.02kg of Tween 80, add it to 1L of water, stir evenly, add 1kg of decoquinate, stir to make it evenly dispersed, and it is Suspension A;

[0036] (2) Add the suspension A into the lactose and stir to make a soft material;

[0037] (3) Granulate the above-mentioned soft materials, dry them (directly dry them in a discharge heat blast drying oven, and control the temperature at about 60°C), crush them through a 60-mesh sieve, and obtain 10.92kg of powder with a measured content of 9.1%, adding Anhydrous glucose 88.5kg is mixed evenly, and packaged separately to obtain the product.

Embodiment 2

[0038] Embodiment 2: prescription of decoquinate dry suspension:

[0039]

[0040] Preparation method:

[0041] (1) Weigh 0.06g of sorbitan laurel, add it to 6L of 20% ethanol aqueous solution, stir well, add 3 kg of decoquinate, stir to make it evenly dispersed, and it is suspension A;

[0042] (2) Homogenize the suspension A twice through a high-pressure homogenizer at a pressure of 700-1000bar;

[0043] (3) Add the above solution into lactose and stir to make a soft material;

[0044] (4) Granulate the above-mentioned soft material, dry (boiling drying, temperature controlled at about 60°C), crush through a 60-mesh sieve to obtain 17.65kg of powder with a measured content of 17.0%, add 82.35kg of anhydrous glucose and mix well, Subpackage, that is.

Embodiment 3

[0045] Embodiment 3: prescription of decoquinate dry suspension:

[0046]

[0047] Preparation method:

[0048] (1) Weigh 3kg of sodium lauryl sulfate, add it to 6L of ethanol, stir evenly, add 3kg of decoquinate, stir to make it evenly dispersed, and it is suspension A;

[0049] (2) Add the above solution into sucrose and stir to make a soft material;

[0050] (3) Granulate the above-mentioned soft material, dry (boiling drying, temperature controlled at about 60°C), crush through a 60-mesh sieve to obtain 15.59kg of powder with a measured content of 18.78%, add 84.41kg of anhydrous glucose and mix well, Subpackage, that is.

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Abstract

The invention relates to a preparation method of a decoquinate dry suspension. Decoquinate is uniformly dispersed in water through a special process to be administrated into chicken. The decoquinate dry suspension has the advantages of easily available adopted accessories, low cost, simple preparation process, stable quality, good suspension effect in water and the like. The decoquinate dry suspension, compared to a premix, is convenient to use, and is simple in preparation process in comparison with decoquinate soluble powder and suspension liquid.

Description

technical field [0001] The invention relates to a method for preparing a decoquinate dry suspension. The decoquinate dry suspension prepared by the method of the invention is uniformly suspended in water, and can be administered by drinking water in broiler chicken breeding, and is convenient to use. Background technique [0002] Chicken coccidiosis is an intracellular parasitic disease mainly caused by one or several kinds of Eimeria, which seriously endangers the growth and development of chickens, especially for chicks and turkeys. The heaviest is one of the most important diseases in intensive poultry farming, with a morbidity rate of 50% to 70%, a mortality rate of 20% to 30%, and up to 80% in severe cases. According to reports, the economic loss caused by coccidiosis in the world is as high as 2 billion U.S. dollars every year, and the annual consumption of anticoccidiosis medicines exceeds 300 million U.S. dollars. The serious consequences of chicken coccidiosis undou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/47A61K47/34A61K47/26A61K47/20A61P33/02
Inventor 夏雪林刘拓刘桂兰
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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