Rivaroxaban oral microsphere preparation
A technology of rivaroxaban and microspheres, applied in the field of rivaroxaban oral microsphere preparations, can solve the problems of restricted use, great differences in solubility and the like
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Embodiment 1
[0012] Mix and stir 50g of hydroxypropylmethylcellulose and 450g of water to obtain a complete solubility solution. Weigh 10 g of rivaroxaban and 50 g of THF, mix and stir to dissolve. The two solutions were mixed and stirred.
[0013] A nozzle-type spray dryer was selected for spraying at a spray temperature of 90°C and a spray speed of 8ml / min to obtain rivaroxaban microspheres with an average particle size of 76 μm.
Embodiment 2
[0015] Mix and stir 10 g of polyvinylpyrrolidone with 90 g of water to obtain a complete solubility solution. Weigh 10 g of rivaroxaban and 50 g of THF, mix and stir to dissolve. The two solutions were mixed and stirred.
[0016] A nozzle-type spray dryer was selected to spray at a spray temperature of 115°C and a spray speed of 3ml / min to obtain rivaroxaban microspheres with an average particle size of 38 μm.
Embodiment 3
[0018] Mix and stir 100 g of polyethylene glycol with 900 g of water to obtain a complete solubility solution. Weigh 10 g of rivaroxaban and 50 g of THF, mix and stir to dissolve. The two solutions were mixed and stirred.
[0019] An atomization-type spray dryer was selected for spray drying at 100° C., a spray speed of 4500 rpm, and a spray speed of 5 ml / min to obtain rivaroxaban microspheres with an average particle size of 53 μm.
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