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Application of lactoferrin in preparing medicine for treating anemia of adipose people with high inflammatory factors

A technology of inflammatory factors and lactoferrin, which is applied in the direction of drug combination, peptide/protein components, antipyretics, etc., can solve problems such as inability to relieve anemia symptoms, achieve the goal of reducing expression, relieving chronic inflammation, and reducing secretion of inflammatory factors Effect

Inactive Publication Date: 2014-02-05
WUXI KINGENEW BIOTECHNOLOGY LIMITED COMPANY
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Problems solved by technology

Research data shows that for obese patients with anemia, supplementing iron with iron supplements, such as ferrous sulfate, heme iron, etc., cannot relieve the symptoms of anemia

Method used

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  • Application of lactoferrin in preparing medicine for treating anemia of adipose people with high inflammatory factors

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Embodiment

[0058] Oral administration of recombinant human lactoferrin capsules in the treatment of iron deficiency anemia in obese people

[0059] Anemia patients with a body mass index (BMI) greater than 30 and hypoferremia, take 100 mg recombinant human lactoferrin capsules orally, twice a day. After two months of administration, serum ferritin (sFtn, serum) and serum total iron (TSI, total serum iron) levels recovered.

[0060] Table 3 is the average value of serum ferritin and serum total iron in 20 patients before and after treatment with 100 mg recombinant human lactoferrin twice a day

[0061] table 3

[0062]

[0063] After two months of administration, the mean values ​​of hepcidin and interleukin-6 in serum were lower than those before treatment. After two months of treatment, the blood hepcidin concentration dropped from 2.8 nmol / L to 1.9 nmol / L, and interleukin-6 dropped from 1.71.2 pg / mL to 1.2 pg / mL.

[0064] The main advantages of the present invention are:

[0065...

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Abstract

The invention relates to an application of lactoferrin in preparing a medicine for treating the anemia of adipose people with high inflammatory factors. When the lactoferrin is taken as the medicine for treating the iron-deficiency anemia of the adipose people with the high inflammatory factors, the anemia of the adipose people with the high inflammatory factors can be effectively treated, wherein the expression hepcidin genes of adipose cells can be effectively inhibited, so that hepcidin in the serum of the adipose people can be restored to a normal level. Thus, the chronic inflammation of the adipose people is effectively relieved; the expression of the inflammatory factors is decreased; and the inflammatory factors and the iron content in the blood of the adipose people are restored to the normal level. If the body mass index (BMI) of the people is greater than 30; and one or multiple high inflammatory factors are detected in the serum of the people, the people are considered as the adipose people, wherein the inflammatory factors comprise interleukin-6 (IL-6), interleukin-2 (IL-2), interleukin-8 (IL-8), TNF (Tumor Necrosis Factor) alpha and C-reactive protein.

Description

technical field [0001] The invention relates to the application of lactoferrin in the preparation of iron-deficiency anemia medicine for obese people with high inflammatory factors. Background technique [0002] Studies have shown that the inflammatory factors secreted by obese people are higher than those of non-obese healthy people. The anemia of obese people is due to excessive obesity. There are a large number of fat cells in the body. Fat cells secrete a large number of inflammatory factors, which stimulate liver cells to express hepcidin gene, iron The upregulation of downregulin leads to the degradation of intestinal cell and macrophage membrane transport protein, so that the iron in small intestinal cells or macrophages cannot be released, causing symptoms of anemia; in this state, common iron supplements, such as ferrous sulfate, Heme iron, etc., cannot effectively improve anemia in obese people with chronic inflammation. Supplementing a large amount of iron through...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/40A61P7/06A61P29/00
Inventor 方锐
Owner WUXI KINGENEW BIOTECHNOLOGY LIMITED COMPANY
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