Application of bacillus coagulans in preparing preparations for preventing and treating helicobacter pylori infection

A technology of Bacillus coagulans and Helicobacter pylori, which is applied in the field of preparing preparations for the prevention and treatment of Helicobacter pylori infection by Bacillus coagulans, which can solve the problems of difficult eradication and lower eradication rate

Active Publication Date: 2014-02-12
QINGDAO EASTSEA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antibiotics are mainly used for treatment, but as the rate of Hp resistance to antibiotics increases

Method used

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Examples

Experimental program
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Effect test

preparation Embodiment 1

[0028] Preparation Example 1 The preparation of bacillus coagulans powder

[0029] 1 Preparation of bacteria powder and identification of strains

[0030] Take samples of human feces, soil, haystack substrate, etc., and then put the samples in a sterilized bottle, take 2 grams of the sample and add it to 18mL of sterilized diluent, mix well, and carry out 10 -1 、10 -2 、10 -3 、10 -4 , 10 -5 , 10 -6 , 10 -7 Gradient dilution, take 10 -5 , 10 -6 , 10 -7 Three dilution gradients, spread on the solid medium for selective single colony isolation of Bacillus coagulans, place in an incubator, culture at 37°C for 48 hours, select a single colony with good growth and inoculate it into the liquid expansion medium of Bacillus coagulans , expanded at 37°C for 48 hours. After the obtained culture solution is centrifuged (12000rpm) to separate the thalline, the thalline is freeze-dried in vacuum to prepare dry bacterial powder, and the number of viable bacteria is 1×10 9 CFU / g or...

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Abstract

The invention relates to an application of bacillus coagulans in preparing preparations for preventing and treating helicobacter pylori infection, and in particular relates to an application in preventing or eradicating gastric or duodenal helicobacter pylori infection.

Description

technical field [0001] The invention relates to the application of bacillus coagulans in the preparation of preparations for preventing and treating Helicobacter pylori infection, in particular to using the Bacillus coagulans to prevent or eradicate Helicobacter pylori infection in stomach or duodenum. Background technique [0002] Helicobacter pylori (Hp) is the main pathogenic bacteria of upper gastrointestinal diseases. At present, antibiotics are mainly used for treatment, but as the rate of Hp resistance to antibiotics increases, the eradication rate is gradually decreasing, and eradication will be more difficult after drug resistance develops. Therefore, it is imminent to find a new eradication program. Contents of the invention [0003] The object of the present invention is to provide a preparation capable of preventing or eradicating gastric or duodenal Helicobacter pylori infection, which preparation is made of Bacillus coagulans. [0004] The preparation of th...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P31/04A61P1/00A23L1/30A23L2/52A23L33/135A61K35/742
Inventor 李洪福崔云龙
Owner QINGDAO EASTSEA PHARMA
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