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Method for preparing caffeoylquinic acid

A technology of caffeoylquinic acid and chloroform, which is applied in the preparation of carboxylic acid esters, chemical instruments and methods, and the preparation of organic compounds, and can solve problems such as industrial separation and discussion

Inactive Publication Date: 2014-02-12
TAIZHOU XINWEI CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In fact, Artemisia annua contains not only artemisinin, but also caffeoylquinic acid (Jian Han, Min Ye, Xue Qiao, Man Xu, Bao-rong Wang, De-An Guo. Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. 2008, (47): 516-525), but this literature only identified caffeic acid quinic acid in the methanol extract class of substances, it was not quantified, nor was the extraction

Method used

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Examples

Experimental program
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Embodiment 1

[0012] Take 100g of Artemisia annua industrial extraction residue after extracting artemisinin with chloroform, add it into the solution of pH=5.0, methanol:water=5:1 according to the solid-liquid ratio of 1:20 (w / w), and soak it under the action of water bath Extracted for 5 hours, the extract containing caffeoylquinic acid was obtained after solid-liquid separation, and 3.1 g of caffeoylquinic acid with a purity of 64% was obtained through liquid-liquid extraction, and then separated and purified by a chromatographic column to obtain caffeoylquinic acid with a purity of 95%. 1.4g caffeoylquinic acid.

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PUM

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Abstract

The invention relates to a method for preparing caffeoylquinic acid, which comprises the following steps of fetching 100g of artemisia annua industrial extraction remainder obtained after extracting artemisinin with chloroform, and adding into a solution of which the pH is 5.0 and the methanol-water ratio is 5:1 according to a solid-liquid ratio of 1:20 (w / w); leaching for 5 hours under the water bath effect; performing solid-liquid separation to obtain extraction liquid containing caffeoylquinic acid; performing liquid-liquid extraction separation to obtain 3.1g of caffeoylquinic acid with purity of 64%; separating through a chromatographic column and purifying to obtain 1.4g of caffeoylquinic acid with purity of 95%.

Description

technical field [0001] The invention relates to a method for preparing caffeoylquinic acid. Background technique [0002] Artemisia annua is a plant of Compositae Artemisia annua L The dry aerial part of . has the effects of clearing heat, detoxifying, and antimalarial. Artemisinin is an active ingredient extracted from Artemisia annua, and it is the only new antimalarial drug internationally recognized in my country. [0003] Artemisia annua is rich in resources in my country, but the current industrial utilization of Artemisia annua is only a product of extracting artemisinin (Li Shiyu, Qi Xiangjuan, He Yujuan. Method for extracting and isolating artemisinin from Artemisia annua plants. CN200510015146.4). Other utilization of Artemisia annua resources mostly stays in Artemisia annua tea, compound granule (Xiao Wei, Wang Zhenzhong and Bi Yuan. A method for the content determination of Chinese patent medicine made from Artemisia annua, honeysuckle and gardenia. CN: 2010101...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C67/56C07C67/48
CPCC07C67/48
Inventor 苗陵生
Owner TAIZHOU XINWEI CHEM
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