Method for measuring content of potassium chloride and sodium chloride in potassium chloride and sodium chloride injection solution

A technique for potassium chloride, sodium chloride and injection, which is applied in the field of determining whether the potassium chloride and sodium chloride contents of potassium chloride and sodium chloride injection meet quality standards, and can solve the problem that the titration end point jump phenomenon is not obvious, Complex operation procedures, secondary pollution and other problems, to achieve the effect of reducing secondary pollution, easy to use, and less sampling

Active Publication Date: 2014-02-12
SICHUAN QILI PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, secondary pollution may occur during actual use
[0004] In the Chinese Pharmacopoeia, the content determination of potassium chloride in the compound sodium chloride injection adopts the sodium tetraphenylborate method. This method is complicated and time-consuming. The sudden jump phenomenon is not obvious and causes errors

Method used

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  • Method for measuring content of potassium chloride and sodium chloride in potassium chloride and sodium chloride injection solution
  • Method for measuring content of potassium chloride and sodium chloride in potassium chloride and sodium chloride injection solution
  • Method for measuring content of potassium chloride and sodium chloride in potassium chloride and sodium chloride injection solution

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Embodiment 1

[0032] The mensuration of embodiment 1 potassium chloride content

[0033] 1) Preparation of blank test solution:

[0034] Dissolve 0.9g of sodium chloride with water and dilute to 100mL, shake well, accurately measure 5.0mL of the resulting solution, put it in a 50mL measuring bottle, add water to dilute to the mark, shake well, and obtain a blank test solution;

[0035] 2) Preparation of reference substance solution:

[0036] Precisely measure 5.0 mL of potassium standard solution ([National Standard Solution GBSG 62020-90 (2601)] National Iron and Steel Materials Testing Center, General Iron and Steel Research Institute) with a concentration of 1000 μg / mL and a medium of 10% HCl, and place it in a 50 mL measuring bottle , dilute to the mark with water, and shake well to obtain a solution with a concentration of 100 μg / mL. Accurately measure 1.0 mL, 2.0 mL, 3.0 mL, 4.0 mL and 5.0 mL of the 100 μg / mL solution, and place them in 100 mL measuring bottles respectively. Then pr...

Embodiment 2

[0077] The mensuration of embodiment 2 sodium chloride content

[0078] 1) Preparation of blank test solution:

[0079] Dissolve 0.3g of potassium chloride with water and dilute to 100mL, shake well, accurately measure 5.0mL of the resulting solution, place it in a 100mL measuring bottle, add water to dilute to the mark, shake well, and obtain a blank test solution;

[0080] 2) Preparation of reference substance solution:

[0081] Precisely measure 5.0 mL of sodium standard solution ([National Standard Solution GBSG 62020-90 (2601)] National Iron and Steel Materials Testing Center, General Iron and Steel Research Institute) with a concentration of 1000 μg / mL and a medium of 10% HCl, and place it in a 100 mL measuring bottle , dilute to the mark with water, and shake well to obtain a solution with a concentration of 50 μg / mL. Accurately measure 1.0 mL, 2.0 mL, 3.0 mL, 4.0 mL and 5.0 mL of the 50 μg / mL solution, and place them in 100 mL measuring bottles respectively. Then pre...

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Abstract

The invention relates to a method for measuring the content of potassium chloride and sodium chloride in a potassium chloride and sodium chloride injection solution, and a method for determining whether the content of potassium chloride and sodium chloride in the potassium chloride and sodium chloride injection solution meets quality standards. The measuring method is carried out through an atomic absorption spectrometry method by an atomic absorption spectrophotometer.

Description

technical field [0001] The invention relates to a method for determining the content of potassium chloride and sodium chloride in potassium chloride and sodium chloride injection, and a method for determining whether the content of potassium chloride and sodium chloride in potassium chloride and sodium chloride injection meets the quality standard method. Background technique [0002] Potassium chloride (KCl) is one of the most basic clinical medicines. It is a product in the national basic medical drug catalog and a national social insurance catalogue. It is mainly used to treat various hypokalemia and has been widely used in various hospitals for a long time. According to the Merck Manual, Seventeenth Edition, p. 157: For KCl supplementation, glucose solution is not an ideal choice, because the subsequent increase in the patient's plasma insulin level can lead to aggravation of transient hypokalemia and exacerbation of symptoms, especially digitalis patient. Finally, whe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
Inventor 邓艳廖立东张康宁
Owner SICHUAN QILI PHARM CO LTD
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