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Preparation method of responsive nanofiber for delivering anti-cancer medicaments

A technology of nanofibers and anticancer drugs, which is applied in fiber processing, pharmaceutical formulations, fiber chemical characteristics, etc., and can solve problems such as easy dispersion and instability of electrospun NIPAAm nanofiber homopolymers

Inactive Publication Date: 2015-06-03
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This polymer can be prepared by electrospinning, but electrospun NIPAAm nanofiber homopolymer is unstable in water and is easily dispersed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] In order to deepen the understanding of the present invention, the following will be further described in detail in conjunction with specific examples.

[0013] (1) Preparation of polymer: Dissolve pre-quantified NIPAAm, AAm, and VP (molecular ratio is 20:3:1) into distilled water containing ammonium persulfate, and the mixture is magnetically stirred and then degassed with argon for 80min, Then N, NN, N, N-trimethylethylenediamine was added as an accelerator, and the polymerization reaction was carried out at room temperature for 30 h, wherein argon gas was always bubbled in, and the resulting reaction mixture was dialyzed for 5 days with a dialysis membrane with a molecular weight cut-off of 2000. , the aqueous solution was replaced with a fresh one every day; the polymer solution was heated and precipitated, and the obtained gel was vacuum-dried at 46°C for 40h and immediately frozen with liquid nitrogen, and then dried in vacuum at 46°C for 40h.

[0014] (2) Electro...

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PUM

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Abstract

The invention discloses a stimuli-responsive nanofiber which is successfully prepared by using an electrostatic spinning method. Block copolymer (poly(N-isopropylacrylamide-acrylamide-vinylpyrrolidone) (P(NIPAAM-AAm-VP)) is used as a preparation material to prepare an adriamycin-loaded nanofiber film. The prepared adriamycin-loaded nanofiber film is extremely stable, and can still keep the shape after cell incubation. According to the nanofiber, the large surface area and the porosity of the nanofiber can be effectively utilized; the nanofiber has application prospect in the field of delivery of anti-cancer medicaments.

Description

technical field [0001] The invention relates to a method for preparing nanofibers based on electrospinning, in particular to a method for preparing stimulus-responsive nanofibers for anticancer drug delivery. Background technique [0002] Controlled release drug treatment technology generally includes the control of specific behaviors of specific drugs within a specific time period. The purpose of a controlled release system is to establish an effective drug medical system. Nanofibers prepared by electrospinning technology construct a novel drug delivery system (DDSs), many natural and synthetic polymers have been prepared into nanofibers of tens to hundreds of nanometers, which can improve the efficiency of chemotherapy and radiotherapy , Reduce the side effects of anticancer drugs to achieve stable storage and selective targeting. [0003] Polyisopropylacrylamide (PNIPAAm) is a smart polymer that can respond to small changes in the environment, such as temperature and pH,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F6/28D01D5/00C08F220/56C08F226/10A61K47/32
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS