New combination comprising N-acetyl-L-cysteine and its use

A technology of cysteine ​​and acetyl group, applied in the field involving N-, which can solve the problems of unreported significant correlation between selenium and diabetes risk, etc.

Active Publication Date: 2014-02-26
IASOMAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"And, although a protective effect of Se on diabetes risk was reported and attributed to its "insulin-like" activity as well as the antioxidant properties of selenium-containing enzymes, a prospective study did not report any significant association between selenium and diabetes risk (Akbaraly TN et al., NutrMetab (Lond). 2010; 7:21)

Method used

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  • New combination comprising N-acetyl-L-cysteine and its use
  • New combination comprising N-acetyl-L-cysteine and its use
  • New combination comprising N-acetyl-L-cysteine and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Embodiment 1: the treatment of vitiligo

[0114] Vitiligo is an acquired pigmentation disorder with depletion of skin melanocytes. As a result, white patches appear on the skin in different parts of the body. The worldwide prevalence of vitiligo varies within the range of 0.1-2%. Vitiligo can be psychologically devastating for affected patients and can affect quality of life, self-esteem, marriage and employment (Halder RM, Chappell JL. Semin Cutan Med Surg. 2009; 28(2):86-92.). The precise pathogenesis remains elusive, with proposed mechanisms falling under the headings of autoimmune, biochemical, oxidative-antioxidative, neurological, and viral. Several studies have shown a toxic accumulation of free radicals against melanocytes leading to their destruction. In fact, red blood cells from patients with vitiligo had lower levels of glutathione compared to control patients.

[0115] In this Example, we report the case of a 45-year-old woman with diffuse vitiligo arou...

Embodiment 2

[0119] Example 2: Skin Cosmetic Treatment

[0120] Skin aging is visually recognizable as wrinkles, loss of elasticity, sagging, and thinning gradually occur in adults. Determination of skin surface texture is therefore of particular importance in the field of dermatology, since such determinations can be used for skin diagnosis as well as evaluation of therapeutic or cosmetic treatments.

[0121] The effects of environmental pollution on the skin are of increasing relevance, and the skin is often degraded by polluting agents with associated aging and dysfunction. Skin is directly exposed to contamination, with an individual surface estimated to be approximately 2 square meters, larger than any other human tissue. Injury mechanisms attributed to pollution are mainly attributed to the induction of oxidative stress and inflammatory responses. These mechanisms drive us to use NAC in combination with SeMet and Mel in mild aging, oily skin, with pimples.

[0122] A 43 year old w...

Embodiment 3

[0125] Example 3: For the antioxidant effect of culturing blastoid cell line (blastoid cell line) in vitro

[0126] method

[0127] Human lymphoblastoid HL60 and proerythoblastoid K562 cell lines were grown in RPMI1640 medium (Invitrogen, Gibco, Milano, Italy) at 37°C, supplemented with 10% fetal bovine serum, 5 μg / ml penicillin, 5μg / ml streptomycin, 2mM glutamine, and conventional subculture three times a week. Cells were treated with menadione alone (control), NAC alone, NAC+Se-methionine (SeMet), NAC+Mel or NAC+SeMet+Mel. In the case of supplementation of SeMet this supplementation was carried out two days before the test by using a solution of SeMet in buffer (concentration such as Figure 4-7 shown in the description). In the case of supplementing Mel, this supplementation was carried out 20 hours before the test by using an ethanol solution (concentration such as Figure 4-7 shown in the description). The ethanol concentration in the growth medium was < 1.3% and contr...

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Abstract

A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

Description

field of invention [0001] The present invention relates to the combination of N-acetyl-L-cysteine, selenium, preferably selenomethionine (selenomethionine) and melatonin (melatonin), and pharmaceutical compositions comprising this combination, which are used in For the treatment of various diseases and conditions such as benign and malignant neoplasia including various cancer types, autoimmune diseases, neurodegenerative diseases, endocrine diseases, type 2 diabetes, all types of fibrosis, amyloidosis , endometriosis, polycystic ovary syndrome, dysmenorrhea, skin disorders including vitiligo, alopecia and psoriasis. The combination is also used as an antimicrobial and for cosmetic purposes. Background technique [0002] The control and regulation of the intracellular redox environment is fundamentally related to cellular processes. For example, loss of cell cycle redox control can lead to a more oxidant environment, promoting progression from G1 to S phase and thus aberran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/095A61K31/198A61K31/4045A61K45/06A61P17/00A61P35/00A61P31/00A61Q19/08A61K8/23A61K8/44A61K8/49A61K8/58
CPCA61K8/58A61L29/08A61K31/28A61K8/23A61K8/63A61K8/447A61K31/198A61K8/4913A61K31/4045A61K31/573A61K31/095A61Q19/08A61K45/06A61P15/00A61P15/08A61P17/00A61P17/06A61P17/14A61P25/00A61P25/28A61P31/00A61P31/04A61P35/00A61P37/06A61P39/02A61P43/00A61P5/00A61P5/24A61P3/10Y02A50/30A61K2300/00
Inventor T.帕拉萨西G.科斯塔E.克拉斯诺斯卡E.皮塔鲁加
Owner IASOMAI
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